CRISPR/Cas9 gene editing comes to OHSU

OHSU scientists: you have a new technology available to you–with special pilot pricing available. Several new methods for genome engineering have been introduced in recent years, the most successful of which is the clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 system. The OHSU Transgenic Mouse Models Core (TMM) has initiated several preliminary CRISPR pilot projects based in part on a recent campus-wide interest survey. Recently, OHSU’s first F1 mice genetically modified using CRISPR mice were produced by the TMM (Lev Fedorov, Ph.D., Director), in collaboration with the lab of Peter Barr-Gillespie, Ph.D. At least four different knockout alleles of the Espnl gene were generated; these required less than six weeks from initiation of the project to F0 mice. All alleles transmitted to the F1 generation. In addition, the TMM has currently initiated pilot CRISPR knock-in projects to optimize methodologies for this approach and is prepared to extend pilot program pricing to other OHSU investigators for a limited time. For additional details, visit the TMM website.

OCTRI Research Forum: Survey Design and Tools, Jan. 26

Join the Oregon Clinical and Translational Research Institute, OCTRI, in a monthly research forum that addresses all things clinical and translational research.

Don’t miss January’s topic: Survey Design and Tools
Learn best practices in creating and using a survey for research and discover available tools offered through OCTRI and other resources. Presenters: Cindy Morris, Rob Schuff and Julie Mitchell.

Monday, Jan. 26, 2015
12 to 1 p.m.
Mackenzie Hall 2201

Click here for more information about the OCTRI Research Forum.

OCTRI invites all faculty and staff to discuss issues and solutions to common obstacles in conducting clinical and translational research. Do you have a clinical or translational research question? Let us know, and we’ll do our best to help during these events! Please submit questions and topic requests to Colleen Berreta.

Save the date!
February OCTRI Research Forum: Creating a Budget for Individual Research
Feb. 24, 2015
12 to 1 p.m.
Mackenzie Hall 2201

InfoEd and OGA classes offered Jan. 14


Research Administration Training & Education (RATE) offers a number of courses for the OHSU research community. On the calendar for next week: OGA and InfoEd.

InfoEd’s Proposal Development module is required for preparing and submissions that go through the Office of Proposal and Award Management (OPAM). The electronic Proposed Project Questionnaire (ePPQ) is completed within InfoEd for both and submissions.

Walk step-by-step through the process of creating and routing an NIH R01 proposal in this hands-on computer lab course. Learn to prepare and route non-R01 proposals as well. After building the proposal, you will learn to complete and appropriately route an electronic ePPQ. Wednesday, Jan. 14, 8:30 a.m. to 12 p.m. in BICC 122.

Oracle Grants Accounting
Oracle Grants Accounting (OGA) is OHSU’s system for managing grants and awards accounts, accessible via the Administration Information System (AIS). OGA is overseen by OPAM, which offers a wealth of online resources.

Learners are introduced to the OGA module functionality, and topics include identification and review of OGA financial reports, analysis of financial information, and application of financial data as it pertains to sponsor terms and conditions. Wednesday, Jan. 14, 1 to 4 p.m. in BICC 122.

These classes and other training is searchable in Compass. Contact Margaret Gardner with any questions.


More from the Mello Lab: Buzzed birds slur their songs

Hot on the heels of their ground-breaking bird genome research, the Claudio Mello Lab and colleagues have published new work showing the effects of alcohol on bird vocalization. This PLOS ONE study, by Christopher Olson, Devin Owen, Andrey Ryabinin, and Claudio Mello, showed that alcohol causes the zebra finches to produce song that is quieter and less organized–in effect, it slurs and softens their songs. Interestingly, the alcohol did not affect other areas of their motor coordination.

This discovery made headlines around the globe this past week. Check out the coverage here:

NPR All Things Considered
Slate Magazine

The Washington Post

Los Angeles Times

New York Magazine

Huffington Post

Red Orbit


The Daily Beast

The Independent’s News Matrix

Pioneer News


Utah People’s Post

International Business Times

Frontline Desk

The Register

Tech Times

Press Herald


Boing Boing

Public Radio East

Metro UK

The Daily Meal
Maine News

Capital Berg
Waterloo Region Record
KGMI 790
Business 2 Community
New York Daily News
Full-Time Whistle
Science World Report
South China Morning Post

And many more!

RCR Training Opportunity for NIH Training Grants

The Oregon Clinical and Translational Research Institute (OCTRI) is offering an 8-hour seminar that meets the RCR (Responsible Conduct of Research) requirements of the NIH K award or T award, or any federal or non-federal career development grant. This seminar is an interactive and practical experience that is focused on addressing real issues that have arisen in the course of your research. This may be related to ethics, integrity and regulatory matters; including anything from how you recruit and consent patients to how you keep laboratory methods and determine authorship.

Eligibility: This seminar is also open to training grant faculty who have an RCR requirement; these faculty members can serve as small group facilitators. Priority is given to scholars and trainees funded by an NIH K-award or clinical or translational, postdoctoral T-award or any federal or non-federal career development grant.

Session 1: February 6, 2 to 4 p.m.
Session 2: February 20, 2 to 4 p.m.
Session 3: March 6, 2 to 4 p.m.
Session 4: March 20, 2 to 4 p.m.

Please contact Karen McCracken for questions and to register.

Parker Lab postdoc highlighted in Journal of Immunology

Timothy Thauland, PhD, a former graduate student and postdoc in David Parker’s lab in the OHSU School of Medicine’s Department of Molecular Microbiology & Immunology, received special mention by the editors of the Journal of Immunology. His article – Boost the Immune Response with High-Quality TLR Ligands – featured in the Dec. 15 “In This Issue” section, was considered to be among the top 10 percent of articles published in the journal. Dr. Thauland is now at Stanford.

Congratulations, Tim!

NIH Fiscal Policy for FY2015

Need budget guidance for NIH awards? Here’s the latest:

  • Funding levels for noncompeting renewals, which have been at about 90% of award, will likely be restored. Those that have yet to be awarded may be awarded in a range between full commitment level to 3% below. See your specific IC for more information.
  • NRSA stipends will increase by about 2%.
  • New investigators should still retain their ‘bonus’.
  • Salaries are capped at $183,300.

Responses to more legislative mandates will be released in January 2015.

See the full notice here.

NIH Salary Guidance for FY2015

The salary cap for NIH awards will increase from $181,500 to $183,300, beginning January 11, 2015. What does this mean for you? See examples and scenarios in the full notice or talk to your OPAM representative.

NRSA Stipends Set for 2015

The new levels for stipends, tuition, institutional allowances, and other relevant budget items have now been updated for all Ruth L. Kirschstein (NRSA) and T32 (and other institutional training) awards.

See the full notice here.

Share files between Mac and PC with, OHSU’s preferred cloud storage system, is more than just a place to securely store files and data. It can also bridge the gap between Apple and Microsoft operating platforms. Box operates independently from any one system, which makes sharing and syncing documents easy.

For employees who work on both a Mac and a PC, the Box Sync plug-in can be especially useful. It gives users the ability to share files and entire folders with just one click, and it updates documents in the cloud automatically whenever changes are saved on any computer.

Log in to Staff News to learn more about Box Sync and other useful tips.

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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