Available now: New express rights option program for OHSU startups

948171048_ab19e27ef4_zBeginning Sept. 1, any newly formed OHSU startup company has the opportunity to obtain time-limited rights to OHSU technology through a new express option agreement program.  New startup companies with founders who are OHSU employees or students now have access to a low-cost, pre-approved agreement that can be completed quickly to secure rights in OHSU technology. This allows the new startup to focus on evaluating the technology further, conducting market research, developing a business plan, and raising funding prior to entering into a more extensive, longer-term license agreement. In general, any technology that has been disclosed to Technology Transfer and Business Development may be eligible for this program.

Benefits of the program include the following:

  • Simple, rapid access to rights to OHSU technology for new startups
  • No time and effort spent on negotiation
  • Quick agreement execution
  • Low upfront costs
  • Six-month agreement term, with the potential for term extension

The goal of the program is to encourage, foster and support the entrepreneurial culture at OHSU. For more information, please refer to the Exclusive Option Agreement for OHSU startups FAQs document or contact Andrew Watson at watsonan@ohsu.edu.

Who’s new at OHSU? Fikadu G. Tafesse, Ph.D.

Fikadu G. Tafesse, Ph.D. is an assistant professor of molecular microbiology and immunology who is working to understand how pathogens utilize host cellular processes during infection. He arrived at OHSU from Boston in February, 2016.

Where are you from originally?
I was born and raised in Ethiopia and got my undergraduate degree in agriculture there, learning how to grow crops – basic farming. After graduation, I decided to go to Europe to gain more experience and ended up going to Germany for a master’s degree in horticulture. This was my first introduction to plant biotechnology and for my master’s thesis I worked on a gene family of phospholipases that modify membranes in plants.fikadu

I always wanted to go back home to Ethiopia; I never thought of staying in Europe or moving to the U.S. But during the second year of my master’s program, a friend who was getting his Ph.D. in epigenetics asked me to take pictures during his thesis defense.  Up to that point, I knew very little about his field but when I heard him talk about DNA methylation and the role it plays in cancer development, I was hooked.  In fact, I completely forgot to take pictures because I was so interested in the science! This made me want to go further with my studies before I went back home. I applied to Ph.D. programs and eventually ended up at Utrecht University in the Netherlands. There, I studied under Joost Holthuis and Gerrit van Meer, two lipid biologists. When I joined the lab, I had no idea they were world-renowned because I hadn’t been in the field. I was very fortunate to learn about lipid chemistry and biochemistry from them. I went on to do my postdoc at the Whitehead Institute at MIT and then went to the Ragon Institute at Harvard for more than a year before coming to OHSU.

Tell us about your research and what drew you to it?
Growing up in Ethiopia, I saw many people die of infectious diseases, and as a result I was naturally curious about the biology of these diseases, particularly HIV, tuberculosis, and malaria – the three main killers in developing countries. So, I decided to do my postdoc in a lab where they worked on host-pathogen interactions. That’s why I went to the lab of Hidde Ploegh at the Whitehead Institute of MIT, to work in a lab with immunologists, microbiologists, chemists, and biochemists. There, I learned about viruses, bacteria, and fungi, and my main focus was on how pathogens use the host’s lipids during infection. I then went to the Ragon Institute at Harvard to work closely with the lab of Sarah Fortune and learn about Mycobacterium tuberculosis. Little is known about the role of lipids in bacterial and viral pathogenesis, so I decided to bring what I’d learned in my postdoctoral research to this new line of work.

Human cells are surrounded by membranes, and those membranes contain lipids. Pathogens must cross membranes to infect cells, so what I’m trying to understand is how a virus such as HIV uses the host machinery, especially that of lipids, during infection. A virus doesn’t have machinery of its own, and it uses the host cellular processes for entry and replication without being detected by the immune system. If we can understand the mechanics of this, then we can design a strategy to block it. This is fundamental to combating these diseases.

What are you working on now?
The research focus in my lab is on M. tuberculosis as well as HIV and viruses from the family Flaviviridae, which includes zika, dengue, and yellow fever. M. tuberculosis is a bacteria that causes tuberculosis. If you look at deaths due to infectious disease globally, tuberculosis is one of the most devastating diseases, especially in developing countries. So I wanted to dedicate my career, in a way, to understanding tuberculosis and HIV-tuberculosis co-infections.

The main reason we don’t know much about lipids and their role in infection is because they are difficult to work with. They are not template coded – there is no DNA that really codes for lipids. They are a bi-product of a series of cellular processes such as metabolism. In research terms, you can’t overexpress it or put a tag on it, so you need a special set of skills to work with and study these metabolites. Most of the techniques we use today to study lipid biochemistry were developed in the 1970s and are very outdated. Since I have strong training in this area, I’m comfortable working on lipids and using various techniques, and I am testing out my initial hypothesis – that lipids are required for bacteria to infect host cells. Our preliminary data strongly suggest they do.

When studying the mechanics of infection by various viruses and bacteria, I ask the question, “Is there similarity between the different pathogens in terms of the way they use these lipids?” This is a very important question, because if there is a commonality, you can develop a strategy that impacts multiple diseases.  Finding the answer to that question is my goal.

In addition to my main research program, I’m also developing tools to study M. tuberculosis. The tool I’m developing uses nanobodies, single-domain antibodies that occur only in camelids and sharks. These unique antibodies are extremely small, so they penetrate tissue very well. In terms of their binding, they are as good as conventional antibodies, but they don’t require any post-translational modifications. They’re stable across a wide range of temperatures and in various pH environments. These characteristics make them very easy to work with. My technology development involves generating nanobodies that can be used not only to study the intricate interaction of the bacteria with the host but that also has the potential for diagnostic and therapeutic value. We do this by immunizing Alpaca with antigens such as M. tuberculosis virulence factors, thereby generating nanobodies that target those factors. We then evaluate whether they prevent infection in macrophages. If they have neutralizing capacity, you have a very good candidate to take to the next level of investigation. At this point we have several candidates.

I currently collaborate with folks on the east coast to do the injections, but eventually I want to have an Alpaca farm that I work with here in Oregon. This is one of the programs I really want to pursue because it has very high potential. If you can block that virulence factor, you have a cure. I just want to make a difference. I hope that what I’m doing can have an impact not only in my home country but other developing countries as well. So, I plan to establish collaborations in Ethiopia and other African countries where these diseases are epidemic. It’s important to connect the work to the place where the real problem is – that’s my long term goal.

Why OHSU?
I was aware of OHSU’s achievements before I came here, particularly in the area of infectious disease such as HIV vaccine development. And with the Oregon National Primate Research Center here, OHSU is a focal point for research into infectious disease in humans. It’s an ideal place to be. On a personal level, as soon as I got here, I really liked the city, the people, this whole region. I knew I could definitely live here, and hey, I’m from Ethiopia – those Boston winters were just too cold for me.

Early-technology development workshop, Sept. 14

Last week, the Oregon Clinical and Translational Research Institute announced its most recent round of funding through the Biomedical Innovation Program: Device, Diagnostic, and Software Development. Commercialization is a key component of the Biomedical Innovation Program and also the area applicants are likely least familiar with. To address this, OCTRI and Technology Transfer and Business Development are teaming up to host a workshop to discuss strategies of concept-to-product development.

“From concept to commercialization: An early-technology development workshop”BIP_workshop_flyer

Wednesday, Sept. 14, 2016
12 to 1 p.m.
Mackenzie Hall, room 3198
Marquam Hill

OHSU community members will learn about the key aspects of determining innovation commercial feasibility and the general commercialization evaluation process at OHSU. Attendees are encouraged to bring an idea with them to receive in-person support from mentors. The workshop, led by OHSU entrepreneurs-in-residence and OCTRI members, will coincide with the 2016 MedTech Alliance Showcase.

A light lunch will be provided. To attend, please RSVP to Jonathan Jubera at jubera@ohsu.edu.

Learn more about the Biomedical Innovation Program.

NCI seeking novel insights on infectious agents associated with cancer

It is well established that certain infectious agents play a role in cancer in humans. Worldwide, infections are linked to over %15 of cancers with much higher numbers in developing countries. The translational potential for this area of research is significant and may lead to new therapies and interventions. In order to support discoveries that could lead to better diagnosis, prevention and treatment of cancers, the National Cancer Institute is seeking input from the biomedical community with research interest in this field for the following:

  • Existing research challenges and gaps in epidemiology studies related to infection-related cancer
  • Recent basic science innovations, approaches, and discoveries in infection-related cancer population-based research
  • Available resources that can be used to investigate the role of infections in cancer occurrence and outcomes
  • Key scientific disciplines that should be integrated with cancer epidemiology to characterize infection-driven carcinogenesis, as well as specific approaches that could be used in the future.
  • Other relevant issues

Send your responses to NCI by October 31, 2016 via email (preferred).

 

Women in Science leadership panel discussion, Sept. 20

Beth Comstock

Beth Comstock

Join Women in Science Portland for a dynamic discussion examining what it takes to become a leader in STEM. Panelists include two top executives from General Electric and leaders from academia and biotech. Don’t miss this unique opportunity to talk with the women who are trailblazing new territory in leadership!

Women in leadership panel discussion

Tuesday, Sept. 20
11:30 a.m. to 12:30 p.m.
Collaborative Life Sciences Building, 1A001

Featured panelists:

Beth Comstock, vice chair, GE Business Innovations

Charlene Grabowski, general manager and vice president of West Zone and Canada, GE Healthcare

Mary Stenzel-Poore, Ph.D., senior associate dean for research, OHSU

Soundharya Nagasubramanian, M.S., director of research and development and Beaverton site executive, Welch Allyn

The event is free, but space is limited. Register today to attend.

For questions or inquiries, please contact Abby Dotson at dotsoab@ohsu.edu.

Women In Science Portland is an organization that provides personal and professional development opportunities for early career scientists and professionals, as well as students and post-docs. The overall mission is to support the growth of women in sciences.

 

Researchers study potential treatment to reduce brain swelling after stroke

Brain swelling resulting from a large, acute stroke event causes further damage and can lead to major disability and death, and there are few effect treatment options. Existing drug regimens do not improve survival or functional outcome. Decompressive craniectomy, a surgical procedure to remove part of the skull, allowing the brain to swell without being squeezed, improves outcomes in some patients but increases survival with major disability in others.

Future treatments are likely to target pathways involved in brain swelling, and several potential candidates have been identified. One of these key mediators is a suphonylurea receptor pathway triggered by ischaemia and hypoxia, that can be inhibited by glyburide, a drug given orally to people with diabetes to control their blood sugar levels. In rodent models of stroke, glyburide, delivered by continuous intravenous infusion, reduces brain swelling. A pilot study involving 10 stroke patients showed the drug is well tolerated, but its efficacy in humans remains unclear.

Holly Hinson, M.D., M.C.R., assistant professor in the Department of Neurology at OHSU, co-authored a paper published on Aug. 23, 2016, in The Lancet Neurology entitled “Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial.” The clinical trial involved 77 patients; 41 participants received intravenous glyburide, and 36 received placebo. Outcomes were measured using the modified Rankin Scale from 0-6 where 0 represents no symptoms at all, and 6 represents death. The percentage of people with a score of 0-4 (healthy to moderate disability) at 90 days was not significantly different between the glyburide and placebo groups, and mortality was not significantly reduced overall. However, function outcome measured by the Rankin Scale was improved in patients treated with the active drug.

Though the primary end point was negative, the results are consistent with the preclinical and pilot studies showing the sulphonylurea receptor pathway plays an important role in the formation of brain swelling, and treatment with intravenous glyburide is well tolerated in acute ischemia stroke patients. The study was cut short due to funding issues, resulting in too small a sample size to  provide statistically significant data on efficacy. But the results are encouraging enough to warrant further investigation. A larger phase 3 trial is planned for early 2017.

This research was funded by Remedy Pharmaceuticals, Inc., and was conducted in collaboration with researchers from Yale University School of Medicine, Medical University of South Carolina, University of Pittsburgh, Massachusetts General Hospital, University of Washington, and University of Maryland.

 

Effort certification and DHHS salary cap refresher training, Sept. 6

Do you need a refresher for coordinating effort certification or applying the Department of Health & Human Services salary cap? Join the Research Administration Training and Education program for an overview, examples, and discussion.

Effort certification, salary cap refresher training
Tuesday, Sept. 6

1:30 to 3:30 p.m.
Center for Health & Healing, room 3181 (1B)
Register in Compass

Topics covered:

  • Review of effort certification process and DHHS salary cap requirements
  • Strategies and tools to ensure accurate, complete, and timely effort statement submissions
  • Opportunity to work through current questions and issues for this effort period

You are welcome to bring any specific questions or issues that need attention.

Questions? Contact the RATE program.

InfoEd, Oracle Grants Accounting training, Sept. 8

Research Administration Training and Education offers a number of courses for the OHSU research community. Next on the calendar are InfoEd and Oracle Grants Accounting.

InfoEd for grants.gov submissions
Thursday, Sept. 8
8:30 a.m. to 12 p.m.
Biomedical Information Communication Center, room 120
Register in Compass.

InfoEd’s Proposal Development module is required for preparing grants.gov and non-grants.gov submissions that go through the Office of Proposal and Award Management. The electronic proposed project questionnaire is completed within InfoEd for both grants.gov and non-grants.gov submissions.

Course objectives: Walk step by step through the process of creating and routing NIH R01 and non-R01 proposals in this hands-on computer lab course. After building the proposal, you will learn to complete and appropriately route an electronic proposed project questionnaire.

Oracle Grants Accounting
Thursday, Sept. 8
1 to 4 p.m.
Biomedical Information Communication Center, room 120
Register in Compass.

Oracle Grants Accounting is OHSU’s system for managing grants and awards accounts, accessible via the Administration Information System and overseen by the Office of Proposal and Award Management, which offers a wealth of online resources.

Course objectives: Learners are introduced to the Oracle Grants Accounting module functionality. Topics include identification and review of the accounting financial reports, analysis of financial information, and application of financial data as it pertains to sponsor terms and conditions.

Please contact the Research Administration Training and Education program with any questions.

NIGMS funding opportunity for new and early-stage investigators

The National Institute of General Medical Sciences has released a Funding Opportunity Announcement for the Maximizing Investigators’ Research Award (MIRA) for New and Early-Stage Investigators (R35). NIGMS introduced this mechanism last year as a pilot program which represented a new funding strategy focused on supporting PIs rather than specific projects. The rationale behind this novel funding strategy was to improve funding distribution and invest in scientists, thereby providing them with funding stability to explore new, creative directions in their research.

Webinar: Sept. 30, 2016, 12 to 1 p.m.
Letter of intent deadline: Oct. 4, 2016
Application deadline: Nov. 4, 2016

MIRA provides support for the research program in an investigator’s laboratory. Research programs in technology development and computational approaches, as well as basic biomedical sciences, translational, clinical research, and all phases of the scientific process, not only hypothesis testing, are supported.

A notable change from the parent announcement is that New Investigators who are no longer Early-Stage Investigators (as defined by NIH) will not be eligible. The investigator must also have not yet received a substantial independent NIH research award to be eligible.

Still have questions? Save the date for the webinar or check out the FAQs page.

Groundbreaking, gene-editing scientist to present OHSU lecture, Oct. 11

Jennifer Doudna, Ph.D. — co-inventor of what some are calling the biotech innovation of the century, a discovery that could revolutionize how we treat and cure disease — will present the OHSU Foundation’s 2016 Calvin and Mayho Tanabe Address in Portland this fall.

Doudna, a biochemist at the University of California, Berkeley, published research in 2012 that detailed a gene-editing technique showing how scientists can alter any organism’s DNA. The monumental discovery, and further development of the technique, offers scientists hope that they may one day be able to rewrite flawed genes in people. It offers the promise of new drugs, new treatments for disease and possibly even the eradication of some inherited diseases.

But the discovery also comes with profound ethical questions. And Doudna has been a leading figure in encouraging a public scientific debate about further study and development of the technique — called CRISPR-Cas9 — and whether it should ever be used to alter a human embryo. “Through dialogue and sharing of information, we as a society can find a consensus on hoDoudna_200w to use CRISPR technology appropriately for the benefit of all humankind,” Doudna said.

“Rewriting the language of life: Impacts and challenges of DNA editing”


Tuesday, Oct. 11, 2016

 7 p.m.
Winningstad Theater
1111 S.W. Broadway in Portland

Tickets are $20, $10 for students. For more information and to purchase tickets, visit the OHSU Foundation website.

This is the second Tanabe lecture sponsored by the OHSU Foundation.

The Calvin and Mayho Tanabe Address was established to offer differing perspectives on important topics. The lecture features national and international speakers who can bring diverse ideas to the community and encourage a free exchange of ideas. Calvin Tanabe, M.D., now a retired neurosurgeon, graduated from the OHSU School of Medicine in 1964. He was an associate professor at OHSU until 1980 and received the OHSU Department of Neurological Surgery’s Distinguished Alumni Award in 2009. Mayho Hung Tanabe, M.D., graduated from the Keio University School of Medicine in Tokyo in 1967. She completed a residency at the OHSU School of Medicine in 1970, and practiced anesthesiology at Emanuel and St. Vincent hospitals in Portland.

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