Researchers: Contribute to the future of the OHSU Website

OHSU research community: you are invited to an open meeting for OHSU community members with an interest in improving lab pages on the OHSU website. The Website Platform Replacement project (WSPR) is creating an opportunity to improve key functionality. OHSU Digital Strategy would like to hear from people about their hopes and dreams for OHSU lab pages. While they cannot promise that every idea will be implemented, they want to understand how lab pages could be better so any modifications are well informed in the interest of better serving OHSU scientists and visitors to their lab pages.

Please join this important session, which will be held Tuesday June 6,  from 12-1 p.m. in Mac Hall 1162.

Demonstration from ProteinSimple, June 13

12036772_934105533346431_8675988888445494822_nChris Brannen from ProteinSimple will be describing two protein platform technologies that could be of interest to OHSU investigators.

Demonstration from ProteinSimple
Tuesday, June 13
10:30 to 11:30 a.m.
Biomedical Research Building, 381

The first platform is Milo, a single-cell protein immunoblotting system. This instrument allows measurement of protein expression in ~1000 individual cells per run, allowing researchers identify which cells in the cell express each protein and how protein expression varies across the population. While single cell transcript analysis has been available for some time, this is the first commercially available system allowing single cell protein detection. The second platform is Wes, a protein separation and detection system that utilizes capillary nanofluidic immunoassay technology, allowing detection of very low protein levels.

Questions? Contact research@ohsu.edu.

Gerlinger Research Award applications due June 4

School of Medicine faculty members are eligible to apply for $10,000 to $40,000 in funding from the Gerlinger Research Award. The award can be used for salary, equipment, or supplies. Preference will be given to research addressing systemic autoimmune or connective tissue diseases. 

Applications are due June 4, 2017.

Presidential bridge funding applications due June 15

The Office of the Senior Vice President for Research has released its call for proposals for the FY18 summer OHSU Presidential Bridge Funding Program. Bridge funding is available for established investigators threatened by an imminent lapse in research support. Investigators can request up to $50,000 in funding for one year to help bridge them while they generate data to restore funding. Up to 10 awards may be made this funding cycle.

Awards are available only to OHSU investigators. The PI must be an independent scientist. Independence is defined by: rank at the level of assistant professor or above; committed institutional support such as space and salary; a track record of first-authored or senior-authored publications; a recent history of federal (or similar) funding; and imminently planned or pending application for funding on a national level. Postdoctoral fellows and similar trainees are not eligible to apply.

Applications must include the following:

  • Bridge Funding Request signed by the PI and chair/unit head describing the need for bridge funding, efforts that have already been made to secure funding, how bridge funds will be used to increase the likelihood of funding renewal, and institutional commitment to the PI during the bridging period and beyond (no more than 2 pages).
  • Reviewer comments and priority scores
  • Letter of Support from applicant’s department chair or institute director
  • CV or biosketch
  • Budget

Applications are due by 5 p.m. on Thursday, June 15, 2017 and must be submitted online via OHSU’s Competitive Application Portal (CAP). Guidelines and applications can be found on CAP or OHSU’s internal funding database.

Construction in Medical Research Building, June 1–August 28

MRB Impact Notification MAY 2017Construction on the first floor of the Medical Research Building will begin on Thursday, June 1, and continue through Monday, August 28. Suite 180 and a few surrounding rooms are being upgraded and remodeled to meet current NIH guidelines and to provide an improved work environment for research.

The construction includes:

  • Upgraded HVAC system, new lighting, and new scrub sinks in the surgery area
  • New shower room
  • New lockers and partitions in the restrooms
  • New door to separate the surgery area and related rooms from the public spaces
  • Minor electrical work and casework cabinets in two procedure rooms

Next week, posters in the MRB first and second floor elevator lobbies will provide details about the types and levels of noise, along with the construction schedule for specific areas.

Is your work impacted by planned or ongoing construction? Contact OHSU Project Manager Shelley Bonaduce at bonaduce@ohsu.edu or Skanska Construction Superintendent Dan Roesler at Dan.Roesler@skanska.com.

Pew Scholars Program for junior faculty; internal applications due June 5

Pew-Charitable-TrustsThe Pew Charitable Trust has invited OHSU to sponsor a single candidate for their Pew Scholars Program in the Biomedical Sciences. This prestigious opportunity provides $60,000 in support per year for four years to assistant professors with outstanding promise in science relevant to the advancement of human health.

The program is open to individuals with a doctorate in medicine or biomedical sciences. As of Oct. 23, 2017, candidates must hold full-time appointments at the rank of assistant professor or equivalent and must have been in such an appointment (tenure- or non-tenure track) for less than three years as of on July 7, 2017. This time may have been spent at more than one institution but time spent in clinical internships, residencies, or in work toward board certification does not count as part of this three-year limit. See full announcement for all eligibility exclusions.

Please note: This competition requires internal coordination. If you intend to apply, please submit a limited submission application via the Competitive Application Portal (CAP) before June 5, 2017.

Previous Pew Scholars from OHSU include:

Questions? Contact funding@ohsu.edu.

OHSU scientists demonstrate health consequences of maternal high-fat diet

By the time they are six, half of all children in the United States require medical attention because of wheezing and other respiratory symptoms. New research conducted at OHSU and published in Physiological Reports demonstrated that a maternal diet high in saturated fat plays a key role in programming airway hyperreactivity—a hallmark of asthma—in their offspring.

Stained liver sections reveal vacuolization only in offspring cohorts actively consuming high-fat diet. Diet cohort legend: NF is normal fat content diet, HF is high fat content diet. The first abbreviation indicates the maternal diet, the second following the hyphen indicates the postnatal diet.

Stained liver sections reveal vacuolization only in offspring cohorts actively consuming a high-fat diet.

Using a mouse model, this research supported findings in observational studies that associate maternal obesity and early life wheezing and asthma. The model removed variables—from genetics and socioeconomic conditions to dietary variation and race—that attend human population studies. In the United States, one in three women with the potential to become pregnant are obese, making childhood respiratory health a potentially widespread public health challenge.

Diet—a high-fat diet and a typical diet—was the only variable in this study, led by Kelvin MacDonald, M.D., an assistant professor of pediatrics. Induced airway hyperreactivity was evaluated in four cohorts: dams fed a high-fat diet, dams fed a normal-fat diet, offspring weaned to the same diet as their mother, and offspring weaned to the opposing fat content diet.

Whether they were weaned to a normal or a high-fat diet, the offspring of dams fed a high-fat diet experienced greater airway hyperreactivity. The results demonstrated that a maternal diet high in saturated fat during pregnancy and lactation plays a key role in programming adult offspring airway hyperreactivity.

This research builds on a 2016 retrospective cohort study by MacDonald and long-time collaborator Cynthia T. McEvoy, M.D., M.C.R., a professor in the School of Medicine Department of Pediatrics. Using data from Kaiser Permanente Northwest, they found that—within a cohort of more than 6,000 pregnancies—children of obese mothers were more likely to use asthma medicines through the first four years of life. The team hopes to now work with Kaiser to identify these same individuals and determine whether the children went on to have asthma.

Proving a direct causal relationship is an important step in advancing research into the long-term consequences for children born to women who are obese or consume a high-fat diet while pregnant.

In addition to MacDonald and Cindy McEvoy, co-authors include Aurelia R. Moran, Ashley J. Scherman, and Astrid S. Platteau from the OHSU School of Medicine.

This work was supported by National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development HD057588 02 (K. D. M.), Parker B Francis Fellowship (K. D. M.), Thrasher Foundation (K. D. M). Oregon Clinical and Translational Research Institute UL1TR000128 (K.D.M. and C.T.M.). 

School of Dentistry Dean’s Seminar Series, May 15

The OHSU School of Dentistry welcomes William Giannobile, D.D.S., D.Med.Sc., Najjar endowed professor of Dentistry & chair of the Department of Periodontics and Oral Medicine at the University of Michigan to present as part of its Dean’s Seminar Series. His talk is titled “Is regeneration of the periodontium a clinical reality?” and will take place:

SoD Dean's Seminar Series-William Giannobile D.D.S. D.Med.Sc

William Giannobile, D.D.S., D.Med.Sc.

Monday, May 15, 2017
Noon – Box lunches will be served
12:15 p.m. – Oregon Dental Conference and SoD Dean’s Fellowship Awards
12:30 – Seminar lecture

OHSU School of Dentistry
Collaborative Life Sciences Building, 3A003A/B
2730 SW Moody Avenue

For more information or questions, contact Kim Wamock at warnockk@ohsu.edu.

Summer Vollum writing class starts July 12

The Vollum Writing Program is a professional science writing course open to OHSU graduate students, postdoctoral fellows, and faculty.

This class uses short lectures, class discussion, and workshop-style writing assignments to help researchers learn to write better papers and grants. Topics include:

  • The basic elements of good scientific writing style, including sentence and document structure
  • Insight into scientific conventions regarding grammar, punctuation, and usage
  • Strategies for revising
  • Dealing with writer’s block and time management
  • Best practices for writing introductions, results, discussions, and grant proposals

The class runs for four weeks, Wednesdays, 9:30 a.m. to 12 p.m., beginning July 12, 2017. Four individual tutorials with the instructor are included. There are no prerequisites for this non-credit professional development course, but you should not take the class unless you have enough data to write about.

The course carries a fee of $500 per student (unless you are in a Vollum lab or part of certain graduate Ph.D. programs). Questions? Contact funding@ohsu.edu.

Access Compass to register for the Vollum Writing Class.

OHSU scientist Ilya Ivlev finds patient decision aids can have big impact

Key research questions: (KQ1) What effect do breast cancer screening patient decision aids (BCS-PtDA) have on younger and older women's intention to undergo screening mammography?; (KQ2) What effect do the aids have on the intention of women (a) in their forties to begin screening and (b) in their seventies to continue screening?

Key research questions: (KQ1) What effect do breast cancer screening patient decision aids (BCS-PtDA) have on younger and older women’s intention to undergo screening mammography?; (KQ2) What effect do the aids have on the intention of women (a) in their forties to begin screening and (b) in their seventies to continue screening?

Screening mammograms can cause significant stress for women—particularly for the 13 percent who receive news that their initial results are abnormal. Yet, for the majority of this 13 percent, additional imaging yields normal findings. False-positive findings occur at a significantly higher rate with annual screening than biennial screening and for women in their forties and seventies who do not have risk greater than the general population, research indicates that breast cancer mortality is not generally reduced with screening.

How many women without major risk factors for breast cancer would undergo screening mammography if they were made aware of rates of false positives and their level of risk with or without screening? A new paper by Ilya Ivlev, M.D., Ph.D., reports that evidence-based breast cancer screening patient decision aids had a significant influence on women’s decisions regarding mammography. The study, published in the March 2017 issue of the Journal of General Internal Medicine, is one of the first to examine the effects of these aids of screening plans on women’s intentions to be screened.

In a systematic review and meta-analysis of three randomized trials, Ivlev, a postdoctoral fellow in clinical informatics, found that, compared to typical care, 77 percent of women aged 38 to 50 who viewed a patient decision aid decided not to undergo screening mammography. The aid was developed by Karen Eden, Ph.D., medical informatics and clinical epidemiology professor at OHSU, and was based on the 2016 findings of Heidi Nelson, M.D., M.P.H., M.A.C.P., research professor and vice chair of medical informatics and clinical epidemiology and medicine at OHSU. Nelson’s research indicated breast cancer mortality with screening compared to nonscreening was not statistically significant for women of average risk who were in in their forties or seventies. However, her meta-analysis revealed that mortality was generally reduced for women aged 50 to 69.

Providing patients with the right treatment at the right time is the goal of these and other scientists at OHSU. Ivlev’s research may inform appropriate approaches to shared-decision making in determining whether to screen average-risk women in their forties.

In addition to Ivlev and Eden, co-authors were Erin N. Hickman, M.D., National Library of Medicine fellow in the Department of Medical Informatics and Clinical Epidemiology, and Marian S. McDonagh, Pharm.D., professor in the Department of Medical Informatics and Clinical Epidemiology and associate director of the Evidence-based Practice Center. The study was supported by United States National Library of Medicine Biomedical Informatics training grant T15LM007088.

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

Participation Guidelines

Remember: information you share here is public; it isn't medical advice. Need advice or treatment? Contact your healthcare provider directly. Read our Terms of Use and this disclaimer for details.

Categories

Archives