Cores Corner

Murine CRISPR/Cas9 pilot program updates

CRISPR/ Cas9 gene editing is rapidly becoming the state of the art for mouse genome engineering. During the last year, the OHSU Transgenic Mouse Models Core has successfully used this technology to generate both targeted gene knock-outs and point mutation knock-ins for its clients. The Transgenic Mouse Models Core has revised its CRISPR pricing structure for 2016. Non-homologous end joining-based gene knock-outs for OHSU investigators will be $2100 per project (150 injections), with the user … Read More

University Shared Resources funding, deadline extended to Dec. 2

The deadline for the following opportunity has been extended to December 2, 2015: The University Shared Resources (USR) program and the Senior Vice President for Research office are soliciting grant applications for the USR Core Pilot Grants program. Each grant will provide up to $10,000 to investigators for pre-award or pilot data generated in the cores. Eligible costs are for core services associated with the development and submission of new grants, including consultation time, reagents, supplies, … Read More

New University Shared Resources funding, applications due Nov. 30

The University Shared Resources (USR) program and the Senior Vice President for Research office are soliciting grant applications for the USR Core Pilot Grants program. Each grant will provide up to $10,000 to investigators for pre-award or pilot data generated in the cores. Eligible costs are for core services associated with the development and submission of new grants, including consultation time, reagents, supplies, and technical staff time for assisting investigators. However, in some cases they could … Read More

OHSU/PNNL team receives $1.8M to support NIH Undiagnosed Disease Network

Investigators from OHSU and the Dept. of Energy’s Pacific Northwest National Laboratory were awarded a three-year $1.8 million grant from NIH to support a nationwide project targeting undiagnosed diseases. OHSU will leverage its newly established collaboration with PNNL, the Northwest Co-Laboratory for Integrated ‘Omics, to support the NIH Undiagnosed Diseases Network (UDN). This award will be used to establish a Metabolomics Core to detect and quantify metabolites which can provide clues to enhance other types of data … Read More

NIH-funded core facilities – future directions and OHSU’s model

As you know, Sally Rockey has stepped down from her position at NIH where she steered the Office of Extramural Research for five years. During Rockey’s tenure, she launched a blog, “Rock  Talk,” that lent transparency to NIH decision making and allowed the research community to voice their opinions. In her last few Rock Talk postings, Rockey shared some insights and updates on current NIH priorities and resources including a discussion on NIH-supported core facilities. … Read More

TTBD Lunch & Learn: Patentable subject matter, Apr. 2

Recent Supreme Court cases have reshaped the landscape of what is and is not patentable subject matter in the United States – particularly in the fields of natural products, diagnostic testing, and software. C. Rachal Winger, of the law firm Lee & Hayes in Seattle, will discuss some of the recent changes. Winger and Jeff Jackson, senior patent associate at OHSU, will then have an informal discussion and answer audience questions about these changes and … Read More

NIH S10 funding for high-end instrumentation

The Shared Instrument Grant Program (S10), which provides groups of NIH-supported investigators funds to purchase or upgrade shared equipment costing up to $600,000) was announced in late January.  A new S10 opportunity will open for applications on April 29, 2015. The High-End Instrumentation (HEI) Grant Program is specifically designed to fund instrumentation that costs at least $600,000. The maximum award is $2,000,000. Types of instruments supported include, but are not limited to, X-ray diffraction systems, nuclear … Read More

OHSU’s Massively Parallel Sequencing Shared Resource receives new equipment

The Massively Parallel Sequencing Shared Resource (MPSSR) has been operating since 2009, providing sequencing services for OHSU investigators who examine genetic profiles as part of their research. Recently, the M.J. Murdock Charitable Trust provided funding for a major expansion of the MPSSR. Among the items funded are: 1) a new Illumina HiSeq 2500; 2) an upgrade of the current Illumina HiSeq 2000 to permit runs with two-lane rapid run flow cells; and 3) a new … Read More

NIH S10 applications for 2015

The Shared Instrument Grant Program (S10) provides groups of NIH-supported investigators funds to purchase or upgrade a single item of specialized, commercially available instrumentation or an integrated instrumentation system. The cost of instrumentation must be at least $50,000 (note that this figure is different from past years, where the lower limit was $100,000) and no more than $600,000. Types of instruments supported include confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell-sorters, … Read More

CRISPR/Cas9 gene editing comes to OHSU

OHSU scientists: you have a new technology available to you–with special pilot pricing available. Several new methods for genome engineering have been introduced in recent years, the most successful of which is the clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 system. The OHSU Transgenic Mouse Models Core (TMM) has initiated several preliminary CRISPR pilot projects based in part on a recent campus-wide interest survey. Recently, OHSU’s first F1 mice genetically modified using CRISPR mice were … Read More

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