Cores Corner

New histopathology consultation service

The Histopathology Shared Resource and the Knight Biolibrary are now offering a histopathology consultation service. Services provided include advice on histologic procedures, histopathological evaluation of both animal and human tissues, evaluation of immunohistochemistry, digital microscopy and microdissection. Please contact Dr. Rosemary Makar (makar@ohsu.edu) or the Histopathology Shared Resource (hsr@ohsu.edu) to discuss projects.

New resource for researchers: KCVI Epigenetics Consortium

OHSU researchers have established the Knight Cardiovascular Institute Epigenetics Consortium to foster research and education in epigenetics. This team of experts assists investigators with the analysis of epigenetic regulation by combining evolving technologies and high-throughput sequencing. Services offered include bisulfite sequencing for DNA methylation, ChIP-seq (histone marks or transcription factors), ATAC-seq, and RNA-seq. The epigenetic consortium supports projects from start to finish, including study design, assays, bioinformatic analyses, and help with interpretation of the results. … Read More

OHSU Researchers: Core Pilot Funds – Update

Update 2 – December 1, 2017:  The University Shared Resources program would like to thank those who applied for FY2018 USR Pilot Fund Grants. They received nearly double the number of applications from 2016 and are working to process them all as quickly as possible. They hope to notify all applicants with a decision on or before Friday, December 8, 2017–and they appreciate the interest in this program. Stay tuned for future opportunities. Update: the deadline for this funding opportunity has … Read More

Motor neurons aren’t the only site for restoring locomotive function

Amyotrophic lateral sclerosis is the most common adult onset motor neuron disease for which there is no cure or treatment that significantly extends life. ALS causes the death of neurons that control voluntary muscles and is characterized by gradually worsening weakness, loss of motor function and, when the individual can no longer breathe, death. The only FDA-approved drug used to treat ALS prolongs on average the lifetime of a patient by two to three months. A feature in neurodegenerative diseases, including about 90 percent … Read More

New bioinformatics services for all OHSU investigators available

Fee-for-service bioinformatics support, focused on next-generation sequencing, became available to all OHSU investigators on July 1, 2017. This interim bioinformatics service will provide additional capacity and will complement the existing Oregon National Primate Research Center bioinformatics service core, which is primarily dedicated to ONPRC investigators, as well as the bioinformatics services provided for Knight Cardiovascular Institute Epigenetics Consortium members. Investigators will have two new tiers of bioinformatics service available to them: (1) flat-fee based QA/QC … Read More

OHSU researchers moving blood testing from the clinic to the home

Organ transplants, cancer treatments, and therapies for chronic diseases all require repeated blood tests to monitor levels of drugs and organ function. Frequently drawing blood from a vein becomes increasingly painful, technically difficult, and potentially traumatizing—especially for children. It is also expensive. In 2016, a record-breaking 33 thousand organ transplants were performed in the United States. An estimated 250,000 recipients of organ transplants performed since 1987 are still living. These individuals will have about 48 tests … Read More

OHSU researchers identify structure linked to insulin secretion

It was more than 30 years ago that an ATP-sensitive potassium (KATP ) channel was identified as the key molecular link between glucose metabolism and insulin secretion. The KATP channels sense metabolic changes and translate these energy fluxes into channel gating, which adjusts membrane excitability and regulates insulin secretion. They are the targets of the sulfonylureas, antidiabetic drugs that increase insulin release from beta cells in the pancreas. Genetic mutations of the channel cause several devastating rare … Read More

Participate in FASEB survey on shared research resources

You’re invited to participate in a national survey on research cores. Much of the life-changing research conducted at OHSU is made possible by the university’s more than 20 research cores. Crucial research activities are supported by state-of-the-art equipment, advanced techniques, and specialized expertise in cores ranging from the Cytogenetics Core Laboratory and Biostatistics & Design Program to Proteomics and Massively Parallel Sequencing. The shared research resources model facilitates research activities at institutions around the world. Providers and users … Read More

Shared instrumentation funding, internal applications due Mar. 17

Last week, NIH released three RFAs related to shared instrumentation. The Shared Instrument Grant Program (S10) provides groups of NIH-supported investigators funds to purchase or upgrade shared equipment costing up to $600,000. The High-End Instrumentation Grant Program is specifically designed to fund instrumentation that costs at least $600,000 with a maximum award of $2 million. Types of instruments supported include, but are not limited to, X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA sequencers, biosensors, electron and … Read More

OHSU researchers develop new model to study S. mutans behavior at protein level

Breakthrough innovation doesn’t happen overnight, and it doesn’t happen without money. OHSU Core Pilot Grants provide OHSU researchers with funds to develop new concepts or methods and to strengthen extramural grant proposals. The program is made possible by University Shared Resources, the School of Medicine, and the Office of the Senior Vice President for Research. In 2016, the University Shared Resources pilot funds provided more than $200,000 for early research by 22 OHSU researchers. With … Read More

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Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at OHSU. Find updates on events, discoveries, and important funding information.

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