Cores Corner

New core service available for authenticating human cell lines

The OHSU DNA Services Core has just launched a new human cell line authentication service.  The assay run in the core uses the Promega GenePrint® 10 system and the Applied Biosystems 3730xl DNA Analyzer to confirm the identity of human cell lines and detect the presence of cell line contaminants through short tandem repeat (STR) analysis. This assay co-amplifies and detects of 9 STR loci plus Amelogenin (gender determining locus), and requires a DNA input of 10 … Read More

Reminder: Applications for University Shared Resources pilot funding due Friday, Oct. 7

This is the final week to submit your applications for the OHSU University Shared Resources Core Pilot Awards program. These awards support OHSU faculty and USR cores by providing pilot funding for principal investigators, especially to support generation of data for new grant applications, as well as to support core development. Applications must be filled out online through OHSU’s Competitive Application Portal (CAP). Full RFA is provided on CAP and can also be found here. Please note: Applicants must … Read More

University Shared Resources pilot award applications due Oct. 7

The OHSU University Shared Resources (USR) program and the Office of the Senior Vice President for Research are soliciting grant applications for the second round of the USR Core Pilot Awards program. These awards support OHSU faculty and USR cores by providing pilot funding for principal investigators, especially to support generation of data for new grant applications, as well as to support core development. The program will provide two types of funding this round: Faculty pilot … Read More

Learn about new technologies and sequencing services in the Integrated Genomics Lab Cores

Join Bob Searles, Massively Parallel Sequencing Shared Resource, and Chris Harrington, Gene Profiling/RNA and DNA Services Shared Resources, who will discuss new genomics technologies available in the cores. Among the new services to be discussed: RNA-seq from FFPE tissue, miRNA sequencing, high throughput DNA and RNA extraction, cell-line authentication, and single cell RNA-seq. All members of the OHSU community are invited to attend.  The Integrated Genomics Lab cores are members of the OHSU University Shared Resources Program. Thursday, … Read More

Murine CRISPR/Cas9 pilot program updates

CRISPR/ Cas9 gene editing is rapidly becoming the state of the art for mouse genome engineering. During the last year, the OHSU Transgenic Mouse Models Core has successfully used this technology to generate both targeted gene knock-outs and point mutation knock-ins for its clients. The Transgenic Mouse Models Core has revised its CRISPR pricing structure for 2016. Non-homologous end joining-based gene knock-outs for OHSU investigators will be $2100 per project (150 injections), with the user … Read More

University Shared Resources funding, deadline extended to Dec. 2

The deadline for the following opportunity has been extended to December 2, 2015: The University Shared Resources (USR) program and the Senior Vice President for Research office are soliciting grant applications for the USR Core Pilot Grants program. Each grant will provide up to $10,000 to investigators for pre-award or pilot data generated in the cores. Eligible costs are for core services associated with the development and submission of new grants, including consultation time, reagents, supplies, … Read More

New University Shared Resources funding, applications due Nov. 30

The University Shared Resources (USR) program and the Senior Vice President for Research office are soliciting grant applications for the USR Core Pilot Grants program. Each grant will provide up to $10,000 to investigators for pre-award or pilot data generated in the cores. Eligible costs are for core services associated with the development and submission of new grants, including consultation time, reagents, supplies, and technical staff time for assisting investigators. However, in some cases they could … Read More

OHSU/PNNL team receives $1.8M to support NIH Undiagnosed Disease Network

Investigators from OHSU and the Dept. of Energy’s Pacific Northwest National Laboratory were awarded a three-year $1.8 million grant from NIH to support a nationwide project targeting undiagnosed diseases. OHSU will leverage its newly established collaboration with PNNL, the Northwest Co-Laboratory for Integrated ‘Omics, to support the NIH Undiagnosed Diseases Network (UDN). This award will be used to establish a Metabolomics Core to detect and quantify metabolites which can provide clues to enhance other types of data … Read More

NIH-funded core facilities – future directions and OHSU’s model

As you know, Sally Rockey has stepped down from her position at NIH where she steered the Office of Extramural Research for five years. During Rockey’s tenure, she launched a blog, “Rock  Talk,” that lent transparency to NIH decision making and allowed the research community to voice their opinions. In her last few Rock Talk postings, Rockey shared some insights and updates on current NIH priorities and resources including a discussion on NIH-supported core facilities. … Read More

TTBD Lunch & Learn: Patentable subject matter, Apr. 2

Recent Supreme Court cases have reshaped the landscape of what is and is not patentable subject matter in the United States – particularly in the fields of natural products, diagnostic testing, and software. C. Rachal Winger, of the law firm Lee & Hayes in Seattle, will discuss some of the recent changes. Winger and Jeff Jackson, senior patent associate at OHSU, will then have an informal discussion and answer audience questions about these changes and … Read More

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