paper of the month

This month’s featured research, published in the Annals of Neurology, identifies a disease in non-human primates that has many similarities to multiple sclerosis (MS). The research is the result of a collaborative effort between multiple departments at OHSU and the Oregon National Primate Research Center (ONPRC). Like MS, Japanese macaque encephalomyelitis (JME) affects a small percentage of non-human primates. Since the macaque colony at ONPRC was established in 1965, only 56 cases of spontaneous, MS-like … Read More

Understanding how the ear can detect sound, particularly faint sounds, has long been perplexing for biologists. The organ of Corti, the anatomical structure within the ear that detects sound, is known to vibrate in response to sound. However, monitoring these vibrations has been difficult, as cells are positioned in within the choclea, deep within the skull. Alfred Nuttall, PhD, director of the Oregon Hearing Research Center, and collaborators from across OHSU worked together to develop … Read More

This month’s School of Medicine Paper of the Month, “The Structure of Lombricine Kinase: Implications for phosphagen kinase conformational changes,” was published in the Journal of Biological Chemistry.  The work is the result of a collaboration between OHSU’s Department of Biochemistry and Molecular Biology’s Olga Kirillova, PhD, Omar Davulcu, PhD, Qing Xie, PhD, Michael Chapman, PhD, and colleagues. The research was partially funded by the first award from the OHSU Emerging Technology Fund. In this … Read More

In this month’s School of Medicine Paper of the Month, OHSU researchers publish findings with positive therapeutic implications for sun-damaged skin. The research team included Jodi Johnson, PhD, Brian Lowell, MS2, Olga Ryabinina, MD, R. Stephen Lloyd, PhD, and Amanda McCullough, PhD.  Their paper, “TAT-Mediated Delivery of a DNA Repair Enzyme to Skin Cells Rapidly Initiates Repair of UV-Induced DNA Damage,” was published in the Journal of Investigative Dermatology. Ultraviolet rays from sun exposure can … Read More

The School of Medicine’s featured paper for February, “Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity,” was recently published in the Journal of Clinical Investigation. The research showcased in this article was preformed by Brian Druker, MD, director of the OHSU Knight Cancer Institute and investigator for Howard Hughes Medical Institute (HHMI); Michael W. Deininger, MD, PhD; Amie S. Corbin, research technician, HHMI; Anupriya Agarwal, PhD, postdoctoral researcher; … Read More

In this month’s featured School of Medicine paper, OHSU researchers discover a role for the molecule OX40 in the imunopathological mechanisms that cause a common eye disorder called uveitis. The article, titled “Activation of OX40 Augments Th17 Cytokine Expression and Antigen-Specific Uveitis,” was published in The American Journal of Pathology. The research is the product of a collaboration between Zili Zhang, MD, PhD, Associate Professor, Department of Pediatrics, and James T. Rosenbaum, MD, Professor, Department … Read More

This December, the School of Medicine’s Paper of the Month features “Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots.” Published in the Proceedings of the National Academy of Sciences, this paper showcases the power of a novel imaging technique called “nanocrystal quantum dot-technology,” developed here at OHSU by Dr. Tanya Vu and Drs. Greengard, Flajolet, and Fichter.  Authors of this month’s article, assistant professor of Biomedial engineering Tanya Vu, Ph.D. (left), … Read More

October 2010′s School of Medicine News features “Defective fatty acid hydroxylase leads to a novel form of neurodegeneration with brain iron accumulation” as its Paper of the Month. This month’s selection, published in Annals of Neurology, is based on research  by Michael Kruer, MD, a fellow in neurodevelopment pediatrics, Susan Hayflick, MD, Professor and Chair, Department of Molecular & Medical Genetics, and colleagues in the Department of Molecular & Medical Genetics. In the paper, the … Read More

September 2010′s School of Medicine News features “Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression” as its Paper of the Month. This month’s selection, published in the Journal of Biological Chemistry, is based on research by Mahta Nili, Doctoral Student, Ujwal Shinde, PhD, Associate Professor, and Peter Rotwein, MD, Professor, from the Department of Biochemistry and Molecular Biology. The … Read More

August 2010’s School of Medicine News features “Dynamic-contrast-enhanced-MRI with extravagating contrast reagent: Rat cerebral glioma blood volume determination” as its paper of the month. This month’s selection, published in the Journal of Magnetic Resonance, was led by Charles Springer, PhD, Director Emeritus, OHSU Advanced Imaging Research Center. The paper demonstrates how OHSU researchers are changing the way scientists use diagnostic drugs to pinpoint diseases such as cancer using magnetic resonance imaging (MRI)–which is advantageous because … Read More