Researchers discover a network of genes that control when puberty begins

Researchers at OHSU and the University of Pittsburgh have identified members of an elaborate superfamily of genes that regulate the timing of puberty in highly evolved nonhuman primates. The Zinc finger, or ZNF, gene family comprises approximately 800 individual genes. A handful of genes in this network serve as a “neurobiological brake” that delay the activation of hypothalamic genes responsible for launching puberty until the end of childhood, thereby preventing the premature awakening of the process. The … Read More

Collaboration accelerates research for acute myeloid leukemia

Less than 25 percent of patients newly diagnosed with acute myeloid leukemia (AML) survive beyond five years. The disease causes more than 10,000 deaths a year in the U.S., and treatment options have remained largely unchanged in 30 years. In 2013, OHSU’s Knight Cancer Institute teamed up with The Leukemia & Lymphoma Society to find a path to treatment for this complex form of leukemia. Their research initiative, Beat AML, brought together nine drug companies and … Read More

OHSU Doernbecher researchers receive Gates Foundation grant to advance tuberculosis vaccine research

David Lewinsohn, M.D., Ph.D., in the Papé Family Pediatric Research Institute at OHSU Doernbecher Children’s Hospital, has been awarded a $3 million grant from the Bill & Melinda Gates Foundation to study whether a particular group of infection-fighting cells, known as T cells, may be viable for the development of a vaccine aimed at combatting the global tuberculosis epidemic. According to the World Health Organization’s 2015 global report, TB claimed 1.5 million lives in 2014 … Read More

OHSU researchers discover how to speed, improve Alzheimer’s clinical trials

What if clinical trials for new Alzheimer’s disease treatments could be made quicker, more efficient and more accurate? Jeff Kaye, M.D., director of OHSU’s Layton Center for Aging and Alzheimer’s Disease Center, has found a way, using new technology to track the behaviors of patients. Kaye and his team of researchers determined that gathering and analyzing rich daily data points from trial participants significantly reduced the sample size required for clinical trials conducted to research … Read More

Research finds prostate cancer patients helped by targeted exercise

Men being treated for prostate cancer through androgen deprivation therapy, or ADT, face a troubling problem: The loss of bone and muscle mass while gaining fat.  The side effects of this treatment put them at risk for heart disease, frailty, and broken bones. But a first-of-its-kind randomized clinical trial is providing evidence that targeted exercise can slow bone loss, reverse muscle weakness, and prevent gains in body fat in men undergoing ADT. Kerri Winters-Stone, Ph.D., … Read More

Research finds face-to-face interactions guard against depression

Spending time with friends and family in person can lower depression risk in older adults, according to a new study led by Alan Teo, M.D., M.S., assistant professor of psychiatry at OHSU and researcher at the VA Portland Health Care System. The study, published this week in The Journal of the American Geriatrics Society, reaffirms research that has long supported the idea that strong social bonds strengthen people’s mental health. But this study was a … Read More

OHSU Casey Eye Institute researchers shed light on retinal neural circuitry

Researchers from the Casey Eye Institute, graduate student Benjamin Murphy-Baum and co-investigator W. Rowland Taylor, Ph.D., have deciphered how neurons in the eye detect the orientation of objects in the visual field. The paper detailing their findings, “The synaptic and morphological basis of orientation selectivity in a polyaxonal amacrine cell of the rabbit retina,” was published in the Sept. 30, 2015, edition of The Journal of Neuroscience. Vision is a complex sensory system triggered by light energy … Read More

OHSU researchers identify enhanced functional connectivity in the brain after methamphetamine exposure

Damien Zuloaga, Ph.D., a former post-doctoral fellow in the Raber lab, and colleagues at OHSU published results of a study examining the effects of methamphetamine (MA) on the sleep-wake cycle. The article, “Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure,” appearing in the 23 September, 2015, edition of Frontiers in Neuroscience, identified MA-induced alterations in coordinated activity in the brain, particularly connectivity involving the ventromedial hypothalamus (VMH). The VMH is the portion of … Read More

Knight Cancer Institute researchers track metastasis with cell-free DNA

Researchers at the OHSU Knight Cancer Institute recently found that sequencing the fragments of tumor DNA that circulate in blood may give a more accurate picture of a patient’s metastatic cancer than can be obtained from biopsies. Paul Spellman, Ph.D., professor of molecular and medical genetics at OHSU, led the study, which showed that whole-exome sequencing of cell-free DNA can find the same clinically relevant mutations identified in DNA from tumor tissue, and it can … Read More

OCT angiography summit draws international attention to pioneering technology

Scientists, clinicians, and engineers from around the world gathered at OHSU’s Casey Eye Institute in July for the first international Optical Coherence Tomography (OCT) Angiography Summit. Participants spent the day sharing their knowledge and discussing applications of a pioneering imaging technology that has the potential to transform how we diagnose and treat patients with common causes of blindness, such as macular degeneration, glaucoma, and diabetic retinopathy. James Fujimoto, Ph.D., was the summit’s distinguished guest speaker, … Read More

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Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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