OHSU researchers visualize architecture of the TARP complex

Glutamate receptors are the most prevalent molecular “switches” mediating communication between nerve cells in the brain. They play keys roles in nearly all human behaviors, from learning to memory and movement, as simply a few examples.  Glutamate receptors are also the targets of a broad range of therapeutic agents, from anti-seizure medications to antidepressants. Glutamate receptors do not function alone, however: they form complexes with other proteins called transmembrane AMPA-receptor regulatory proteins, or TARPs. These accessory proteins modulate … Read More

OHSU investigators uncover factors driving “low-value care”

Waste accounts for roughly 20 percent of spending in the U.S. health care system. A significant portion of that waste is attributed to low-value care – unnecessary tests and treatments that are not only costly but provide little clinical benefit or may even harm patients. However, little was known about the patterns and drivers of this type of care. In a first-of-its kind study, researchers from OHSU’s Center for Health Systems Effectiveness (CHSE), compared low-value … Read More

OHSU researchers develop new technique for selecting gene-corrected cells

Gene therapy offers great promise for treating genetic disorders and in repairing or correcting injury and disease. However, efforts to modify and expand the pool of gene-edited cells to reach therapeutic levels have proved challenging to date. Current methods are not only time consuming and expensive, but also present a risk to the patient. Now a team of researchers led by Sean Nygaard, B.S., M.Div., senior research associate in the Markus Grompe Lab at OHSU’s Oregon … Read More

OHSU researcher’s discovery paves way for improved treatments for hearing-impaired

A team led by Lina A.J. Reiss, Ph.D., assistant professor in the OHSU School of Medicine’s Otolaryngology – Head & Neck Surgery Department, has discovered that as many as half of individuals wearing bilateral hearing devices experience abnormal processing of sounds that worsens their auditory perception, particularly speech recognition. Much progress has been made in the treatment of hearing loss with the development of hearing aids (HA) and more recently, cochlear implants (CI). In particular, combining acoustic and electric hearing from … Read More

Newgard paper is AEM editor-in-chief pick for May 2016

Craig Newgard, M.D., M.P.H., director of OHSU’s Center for Policy and Research in Emergency Medicine, was recently recognized by Academic Emergency Medicine (AEM) for his research on gun violence mapping. Newgard et al.’s paper, “A geospatial analysis of severe firearm injuries compared to other injury mechanisms: Event characteristics, location, timing, and outcomes,” was chosen by AEM’s Editor-in-Chief Jeffrey Kline, M.D., as May’s feature. In this study, Newgard and his team performed a secondary analysis of … Read More

OHSU authors’ paper on Nature Neuroscience cover

A paper co-authored by OHSU researchers is featured on the cover of May 2016’s Nature Neuroscience. The paper’s authors are Stephanie L. Padilla, Jian Qiu, Marta E. Soden, Elisenda Sanz, Casey C. Nestor, Forrest D. Barker, Albert Quintana, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly, and Richard D. Palmiter.  Ronnekleiv and Kelly are professors in the Department of Physiology and Pharmacology in the OHSU School of Medicine and senior scientists with the Oregon National Primate Research Center. … Read More

Eric Gouaux’s serotonin transporter research featured by NIH

Recent findings by Vollum Institute senior scientist, Eric Gouaux, Ph.D., and team that reveal the molecular structure of the human serotonin transporter, are getting a lot of attention from the biomedical community and the media. Gouaux’s study was featured in NIH Research Matters, the online publication that highlights groundbreaking NIH-funded discoveries. The article, “Serotonin transporter structure revealed,” discusses the innovative technique developed by the team that allowed them to use X-ray crystallography to capture a 3-D image of the … Read More

Study confirms mitochondrial mutations increase with age, impact stem cell treatments

A team led by Shoukhrat Mitalipov, Ph.D., director of the Center for Embryonic Cell and Gene Therapy at OHSU, has confirmed that mutations in mitochondrial DNA accumulate with age and can limit cells’ ability to create energy and function properly. The study examined induced pluripotent stem (iPS) cells derived from patients’ skin or blood cells and identified faulty DNA, with each cell having potentially different types and percentages of mutations. These defects could undermine the … Read More

Researchers demonstrate the impact of obesity on emergency contraception

OHSU clinical researchers Alison Edelman, M.D., M.P.H., and Jeffrey Jensen, M.D., M.P.H., published a study that examined why emergency contraception isn’t as effective in obese women, and how to potentially increase its effectiveness in this population. The findings, published March 19 in the journal Contraception, show how obesity adversely impacts circulating levels of emergency contraception, and that doubling the dose appears to correct obesity-related interference in the drug’s efficacy. Roughly half of all pregnancies in the U.S. are unintended. Single-dose emergency … Read More

Gouaux lab researchers visualize serotonin transporter structure, create platform for antidepressant drug design

Researchers at OHSU’s Vollum Institute have revealed the molecular structure of the serotonin transporter (SERT), providing new insight into the mechanism of antidepressant action of two widely prescribed selective serotonin reuptake inhibitors (SSRIs) commonly used to treat depression. In their paper, “X-ray structures and mechanism of the human serotonin transporter,” published Apr. 6, in the journal Nature, authors Jonathan Coleman, Ph.D., Eric Gouaux, Ph.D., and Evan Green, describe their use of X-ray crystallography to capture … Read More

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