Discoveries

OHSU scientist Jon Hennebold identifies key pathway in ovulation

Individuals should have the opportunity to have the number of children they want—that is the dogma of the laboratory of Jon Hennebold, Ph.D. To make that possible, Hennebold, chief of the Division of Reproductive & Developmental Sciences at the Oregon National Primate Research Center, focuses on identifying and characterizing the molecular events necessary for ovulation in primates. Most of what we currently know about the ovulation cycle stems from data generated using rodent models, but there is … Read More

OHSU researchers moving blood testing from the clinic to the home

Organ transplants, cancer treatments, and therapies for chronic diseases all require repeated blood tests to monitor levels of drugs and organ function. Frequently drawing blood from a vein becomes increasingly painful, technically difficult, and potentially traumatizing—especially for children. It is also expensive. In 2016, a record-breaking 33 thousand organ transplants were performed in the United States. An estimated 250,000 recipients of organ transplants performed since 1987 are still living. These individuals will have about 48 tests … Read More

Jacob Raber’s team sheds new light on diet and genetics in cognitive impairments

New OHSU research suggests that the risk of developing Alzheimer’s disease is elevated in people with insulin resistance, the effects of which may be ameliorated by a low-fat diet. The study, published in the journal Scientific Reports, was led by Jacob Raber, Ph.D., professor of behavioral neuroscience, neurology, and radiation medicine, School of Medicine, and sheds new light on the shared mechanisms that could explain the overlapping pathophysiology of genetic risk factor and diet. A diet high in saturated fats is a primary contributor … Read More

OHSU researchers discover a mechanism promoting neural stem cells

A breakthrough study by OHSU scientists demonstrates, for the first time, a mechanism that prevents the formation of new neurons in old brains. The discovery provides a new path for investigation that may lead to the prevention—and potentially the reversal—of age-related dementia by promoting the formation of neurons and preventing their decline. The production of neurons drops dramatically during aging, and the brain slows down. New reports continue to emerge that suggest—but do not prove—that … Read More

OHSU researchers identify gene driving responses to brain injury

In response to brain injury, cells in the nervous system swiftly coordinate events that promote survival and repair. Glial cells—the most abundant cells in the nervous system—quickly locate the trauma site, clear damaged neurons, and recruit extra immune cells. This cascade of glial cells’ reactive events is promoted by Draper, an engulfment receptor needed to recognize and clear cellular debris in fruit flies, roundworms, and mammals. Until recently, the pathways that mediate glia responses to … Read More

OHSU researchers identify structure linked to insulin secretion

It was more than 30 years ago that an ATP-sensitive potassium (KATP ) channel was identified as the key molecular link between glucose metabolism and insulin secretion. The KATP channels sense metabolic changes and translate these energy fluxes into channel gating, which adjusts membrane excitability and regulates insulin secretion. They are the targets of the sulfonylureas, antidiabetic drugs that increase insulin release from beta cells in the pancreas. Genetic mutations of the channel cause several devastating rare … Read More

Vaccine technology developed by OHSU researchers acquired by industry

OHSU researchers made international headlines in 2013 when they published findings that their HIV vaccine not only controlled SIV, the nonhuman primate form of HIV, but cleared it in nearly 60 percent of the monkeys in the trial. The HIV vaccine—developed by of a team of scientists at the OHSU Vaccine and Gene Therapy Institute that includes Jay Nelson, Ph.D.; Klaus Frueh, Ph.D.; Scott Hansen, Ph.D.; and Louis J. Picker, M.D.—has shown such promise in … Read More

OHSU researchers develop new model to study S. mutans behavior at protein level

Breakthrough innovation doesn’t happen overnight, and it doesn’t happen without money. OHSU Core Pilot Grants provide OHSU researchers with funds to develop new concepts or methods and to strengthen extramural grant proposals. The program is made possible by University Shared Resources, the School of Medicine, and the Office of the Senior Vice President for Research. In 2016, the University Shared Resources pilot funds provided more than $200,000 for early research by 22 OHSU researchers. With … Read More

OHSU researchers identify complex required for healthy brain

The intricately orchestrated series of events in nervous system development begins with the formation of neuroepithelial stem cells. These cells proliferate, creating progenitor cells that ultimately form neurons and the glia that provide support and protection for neurons. The balance of neurons and glia is fundamental to the development of a healthy brain. Achieving the optimal neuron–glia balance depends on a delicate relationship between the proliferation of progenitors and the differentiation of neurons and glia. … Read More

OHSU addiction researchers find opportunity for intervention

Patients with substance use disorders often suffer from and are hospitalized due to chronic illnesses that cause medical conditions such as abscesses and cardiovascular disease. Hospitalization temporarily disrupts drug use and can bring patients an increased awareness of mortality, the harmful effects of substance use, and its costs on relationships, including parenting. Some evidence also suggests that initiating medication-assisted treatment during these hospitalizations can increase the likelihood of patients engaging in substance use disorder treatment … Read More

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Welcome to the Research News Blog

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