Discoveries

OHSU researchers identify structural changes in the cannabinoid receptor, yielding new insights into alternate GPCR signaling states

If you’re a vertebrate animal, you should be interested in new findings from the Farrens lab. All vertebrates use G protein-coupled receptors (GPCRs) to detect a variety of different stimuli. Upon binding their target molecules, these membrane proteins undergo structural changes that induce internal signal transduction cascades and alter cellular responses. Because GPCRs are involved in so many signaling systems and diseases, they are a common drug target in pharmacology. Recently, two exciting new areas … Read More

OHSU researchers develop a novel gene and stem cell technique for treating mitochondrial disease

A study led by OHSU researchers Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy and the Oregon National Primate Research Center, has revealed a critical first step in developing a new gene and stem cell regenerative technique for treating patients with mitochondrial disease. Mitochondrial diseases result from DNA mutations that lead to altered cell function. Cell injury and cell death result which can lead to multiple system failure … Read More

New insights on protein movement from the Chapman lab

A study from the Michael Chapman lab titled “Parsimony in protein conformational change,” published in the journal Structure, provides a more complete picture of how proteins move. The researchers used nuclear magnetic resonance spectroscopy to better understand the dynamics of protein movement and thus get a better view of their normal functioning. The team designed a computer method that looks at two different snapshots of the same protein structures. Some of the findings: Minimal torsion … Read More

New Science paper from the Skach Lab sheds light on protein folding

A recent paper published in Science may change how we think about how protein folding in its endogenous context.  For the past 50 years, the principles by which proteins unfold and refold have been studied largely using purified recombinant substrates.  Under these experimental conditions, however, it has been extraordinarily difficult to examine how a protein folds in its native environment.  To address this question, the Skach Lab developed a novel technique that uses fluorescence resonance … Read More

The war on melanoma: Skin cancer research and sun safety expo, May 30

In a state more known for rain than sunshine, one would think skin cancer wouldn’t be much of a concern in Oregon. The fact is, Oregon ranks fifth in the nation for melanoma, the most serious of all skin cancers. Researchers at OHSU are on the case, declaring war on melanoma and engaging patients, survivors and the community to figure out how best to prevent, treat and detect the disease. Sancy Leachman, M.D., Ph.D., director … Read More

Gouaux lab breakthrough: How drugs disrupt dopamine

New findings published today in the journal Nature reveal how drugs of addiction disrupt the dopamine pathway. Research from the lab of Eric Gouaux, Ph.D., senior scientist at the Vollum Institute and Howard Hughes Medical Institute investigator, shows precisely how cocaine and amphetamine affect normal functioning of dopamine by disrupting the dopamine transporter. These findings are important because while we know that cocaine and amphetamine interfere with dopamine, how this happens has been a long-standing … Read More

OHSU discovery leads to clinical trials of West Nile virus vaccine

OHSU has discovered and developed a novel investigational vaccine aimed at preventing West Nile virus, which poses a significant public health threat in the U.S. The vaccine, developed by scientists at the Oregon National Primate Research Center, is beginning evaluations in a NIH-sponsored Phase 1, first-in-human, clinical trial at Duke University. No West Nile virus human vaccine has yet been approved for commercial use. Mark Slifka, Ph.D., professor of molecular microbiology and immunology in the … Read More

OHSU and Pacific Northwest National Laboratory team up to promote biomedical discovery

OHSU and the Department of Energy’s Pacific Northwest National Laboratory in Richland, Wash., have formed the  OHSU-PNNL Northwest Co-Laboratory for Integrated ‘Omics. This partnership allows both parties to share their research programs and leading-edge technology for biological mass spectrometry to pursue disease markers for new therapies. In essence, the two entities are working together to answer some of the world’s most complex biomedical questions and accelerate discovery. Through a memorandum of understanding, the institutions have … Read More

Lecture: “OregonHeart: Developing a total artificial heart,” May 28

The Knight Cardiovascular Institute invites you to attend “OregonHeart: Developing a total artificial heart,” a lecture providing an overview of the KCVI’s new company aimed at developing a successful total artificial heart device to treat patients with end-stage heart failure. OregonHeart’s Chief Scientific Officer and renowned inventor of the Hemopump, Richard Wampler, will present, along with other company representatives and OHSU faculty collaborators. Thursday, May 28, 2015 5 to 6:30 p.m. Collaborative Life Sciences Building, … Read More

Casey Eye Institute researchers develop technology to address blindness

Researchers at OHSU’s Casey Eye Institute have developed a technology – optical coherence tomography (OCT) angiography – to better diagnose and manage the leading causes of blindness in the U.S. – retinal vascular diseases such as macular degeneration, diabetic eye disease, and glaucoma. According to research published this week in the Proceedings of the National Academy of Sciences, OCT provides a more precise and less invasive alternative to conventional dye-based retinal angiography used for screening and monitoring. OCT … Read More

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

Participation Guidelines

Remember: information you share here is public; it isn't medical advice. Need advice or treatment? Contact your healthcare provider directly. Read our Terms of Use and this disclaimer for details.

Categories

Archives