Discoveries

OHSU researchers reveal atomic structure of a key molecular receptor

The receptor proteins of a cell’s surface are important transmitters of signals between its internal and external environments. The P2X integral membrane proteins, first defined in 1976, modulate processes as diverse as platelet activation, smooth muscle contraction, synaptic transmission, inflammation, hearing and taste, making P2X receptors important pharmacological targets. P2X receptors are activated by ATP, a major intracellular energy source, resulting in a change in the receptor’s structure and the flow of ions such as … Read More

OHSU researchers reveal mechanism of neuronal activity that controls fertility

Reproductive function is a highly regulated process that depends on certain hormones interacting in a controlled and rhythmic manner.  The hypothalamus and pituitary together control pubertal development and fertility; the hypothalamus releases a chemical messenger called gonadotropin-releasing hormone, which attaches to specific receptors of the pituitary gland, in turn releasing reproductive hormones that control ovulation in females and sperm production in males. In females, the hypothalamus releases GnRH in appropriately timed pulses and in one … Read More

New research shows search and destroy function for leukemia cells

The rapid growth of leukemia cells that “crowd out” healthy stem cells within the bone marrow has traditionally been considered the root cause for prolonged risk of infections and necessary blood transfusions. A study recently completed by a team of OHSU pediatric cancer biology researchers in the Pape Family Pediatric Research Institute – and published in the journal Science Signaling –  disputes this theory and provides the first description of leukemia cells’ ability to actively … Read More

Researchers study potential treatment to reduce brain swelling after stroke

Brain swelling resulting from a large, acute stroke event causes further damage and can lead to major disability and death, and there are few effect treatment options. Existing drug regimens do not improve survival or functional outcome. Decompressive craniectomy, a surgical procedure to remove part of the skull, allowing the brain to swell without being squeezed, improves outcomes in some patients but increases survival with major disability in others. Future treatments are likely to target pathways involved in brain swelling, and … Read More

OHSU researchers elucidate the role of diet in treating people with MS

A first-time controlled clinical trial found that a low-fat, plant-based diet significantly improved the health of people with multiple sclerosis (MS) by reducing both fatigue and weight. Those improvements go hand-in-hand with fighting some of the most debilitating effects of MS, according to the study’s lead author, Vijayshree Yadav, M.D., a MS neurologist with the Oregon Brain Institute at OHSU. While the new research did not show differences in the MS lesions on the brain … Read More

Meet the inventors: Register for MedTech Alliance Showcase Sept. 14

The 2016 MedTech Alliance Showcase connects investors, industry partners, and community collaborators with OHSU inventors and technologies. At this event, attendees will have the opportunity to network and learn more about OHSU medical technologies, including early-stage inventions that have a realistic chance for commercialization. The opening address will be given by John Ma, M.D., F.A.C.E.P., professor and chair of the OHSU Department of Emergency Medicine. Four presenters will take the stage to showcase their technologies. … Read More

Co-invented by OHSU’s David Huang 25 years ago, OCT technology helps detect and stop blindness

This year marks the 25th anniversary of the invention of Optical Coherence Tomography technology, co-invented by Oregon Health & Science University Casey Eye Institute’s David Huang, M.D., Ph.D., while Huang was a Ph.D. student with James Fujimoto, Ph.D. at Massachusetts Institute of Technology. To commemorate the anniversary, the Association for Research in Vision and Ophthalmology (ARVO) published a special anniversary edition in their journal Investigative Ophthalmology & Visual Science with more than 70 articles. OCT is the … Read More

Study led by OHSU researchers provides evidence of immune therapy efficacy in treating metastatic prostate cancer

Programmed cell death 1 (PD-1) inhibitors have shown anti-tumor activity in patients with melanoma, renal cell, non-small cell lung cancer, and bladder cancer. However, patients with castration-resistant prostate cancer demonstrated no response to such immunotherapies in past studies. Now, a research team led by Julie Graff, M.D., assistant professor and oncologist with the Knight Cancer Institute, has shown clear evidence of meaningful clinical activity for PD-1 blockade in men with metastatic prostate cancer resistant to … Read More

Grompe lab discovery offers new clues to diabetes causes and treatment

Diabetes affects nearly 30 million people in the United States. The disease is caused by dysfunction or loss of insulin-producing beta cells that normalize blood sugar levels in the body. Until now, only one type of beta cell was known to exist. But OHSU researchers have developed a method allowing them to identify and isolate four separate subtypes that differ in their susceptibility to metabolic stress and their capacity to proliferate or change from one cell type … Read More

OHSU researchers visualize architecture of the TARP complex

Glutamate receptors are the most prevalent molecular “switches” mediating communication between nerve cells in the brain. They play keys roles in nearly all human behaviors, from learning to memory and movement, as simply a few examples.  Glutamate receptors are also the targets of a broad range of therapeutic agents, from anti-seizure medications to antidepressants. Glutamate receptors do not function alone, however: they form complexes with other proteins called transmembrane AMPA-receptor regulatory proteins, or TARPs. These accessory proteins modulate … Read More

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Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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