Discoveries

Institute of Medicine finds mitochondrial replacement therapy is ethical

In findings released February 3, an  Institute of Medicine panel has deemed mitochondrial transfer therapy ethical. This has important implications for the basic research of OHSU’s Shoukhrat Mitalipov and colleagues in the Center for Embryonic and Gene Therapy, though a Congressional ban on researching this therapy in humans remains in effect. Update: The IOM panel’s report has garnered major media interest–for example, see more here, here, here, and here.

Hope for patients suffering from vision loss due to glaucoma and diabetic retinopathy

New findings from OHSU’s von Gersdorff lab shed light on the underlying mechanism of progressive vision loss caused by diseases such as glaucoma and diabetic retinopathy. In a paper published on Jan. 21, in the journal Neuron, the team led by postdoctoral researcher Mean-Hwan Kim, Ph.D., details their discovery of a new synaptic mechanism that uses the eye’s inhibitory neurons to block toxic excitability occurring in the retina of those suffering from glaucoma and diabetic retinopathy. This discovery suggests the … Read More

Doernbecher scientists define first link between lead exposure and ADHD

Researchers at OHSU Doernbecher Children’s Hospital have defined for the first time a causal link between blood lead exposure and attention deficit hyperactivity disorder in humans. While previous studies have associated lead blood levels with ADHD, research published in Psychological Science is the first to confirm previous hypotheses that exposure to lead in miniscule amounts typical in the U.S., or less than 10 parts per billion, increases symptoms in some individuals with ADHD. The paper … Read More

OHSU study sheds light on risks of giving birth in and out of a hospital setting

The out-of-hospital birth rate in Oregon is the highest of any state (4%) and nationally, more and more women are choosing to give birth at home. This national trend has drawn increased attention to an ongoing debate over whether it’s safe to give birth in an out-of-hospital setting. A new study published the Dec. 31 issue of the New England Journal of Medicine by OHSU researchers provides detailed answers to shed light on the issue. The … Read More

OHSU researchers find cognitive dysfunction resulting from obesity, diabetes can be treated

Brief Reduction in Dietary Fat Improves Cognitive Dysfunction in Mice with Obesity and Type II Diabetes OHSU researchers, led by Jacob Raber, Ph.D., have discovered that the cognitive dysfunction that that often results from obesity and type II diabetes can be treated.  The study reveals that even a brief reduction in dietary fat content in mice that are fed a high-fat diet for a substantial period of time led to a complete rescue of cognitive function. … Read More

Hope for MS patients through understanding roots of the disease in monkeys

New research led by Scott W. Wong, Ph.D., senior scientist, Vaccine and Gene Therapy Institute; interim division chief, Division of Pathobiology and Immunology at the Oregon National Primate Research Center; and professor, OHSU’s Department of Molecular Microbiology and Immunology, describes the similarities between multiple sclerosis and a unique, spontaneous paralytic disease that occurs in nonhuman primates. This model opens the door to discovering the mechanisms driving MS in humans. The model, called Japanese macaque encephalomyelitis, … Read More

Researchers discover a network of genes that control when puberty begins

Researchers at OHSU and the University of Pittsburgh have identified members of an elaborate superfamily of genes that regulate the timing of puberty in highly evolved nonhuman primates. The Zinc finger, or ZNF, gene family comprises approximately 800 individual genes. A handful of genes in this network serve as a “neurobiological brake” that delay the activation of hypothalamic genes responsible for launching puberty until the end of childhood, thereby preventing the premature awakening of the process. The … Read More

Collaboration accelerates research for acute myeloid leukemia

Less than 25 percent of patients newly diagnosed with acute myeloid leukemia (AML) survive beyond five years. The disease causes more than 10,000 deaths a year in the U.S., and treatment options have remained largely unchanged in 30 years. In 2013, OHSU’s Knight Cancer Institute teamed up with The Leukemia & Lymphoma Society to find a path to treatment for this complex form of leukemia. Their research initiative, Beat AML, brought together nine drug companies and … Read More

OHSU Doernbecher researchers receive Gates Foundation grant to advance tuberculosis vaccine research

David Lewinsohn, M.D., Ph.D., in the Papé Family Pediatric Research Institute at OHSU Doernbecher Children’s Hospital, has been awarded a $3 million grant from the Bill & Melinda Gates Foundation to study whether a particular group of infection-fighting cells, known as T cells, may be viable for the development of a vaccine aimed at combatting the global tuberculosis epidemic. According to the World Health Organization’s 2015 global report, TB claimed 1.5 million lives in 2014 … Read More

OHSU researchers discover how to speed, improve Alzheimer’s clinical trials

What if clinical trials for new Alzheimer’s disease treatments could be made quicker, more efficient and more accurate? Jeff Kaye, M.D., director of OHSU’s Layton Center for Aging and Alzheimer’s Disease Center, has found a way, using new technology to track the behaviors of patients. Kaye and his team of researchers determined that gathering and analyzing rich daily data points from trial participants significantly reduced the sample size required for clinical trials conducted to research … Read More

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Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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