Participate in FASEB survey on shared research resources

FASEBYou’re invited to participate in a national survey on research cores. Much of the life-changing research conducted at OHSU is made possible by the university’s more than 20 research cores. Crucial research activities are supported by state-of-the-art equipment, advanced techniques, and specialized expertise in cores ranging from the Cytogenetics Core Laboratory and Biostatistics & Design Program to Proteomics and Massively Parallel Sequencing.

The shared research resources model facilitates research activities at institutions around the world. Providers and users of shared research resources in the United States have been invited by the Federation of American Societies for Experimental Biology participate in a survey of their experiences with shared resources. FASEB is a significant policy voice of biological and biomedical researchers and the survey will inform the organization’s policy discussions and future activities related to shared research resources.

FASEB encourages researchers to share the survey link with their colleagues and collaborators.

The survey is open to providers and users of shared research resources in the United States and takes 10 to 15 minutes. Topics in the survey range from resource utilization and unmet needs to careers in resource provision and development as well as training on best practices.

Responses should be submitted by March 2.

 

Shared instrumentation funding, internal applications due Mar. 17

Last week, NIH released three RFAs related to shared instrumentation. The Shared Instrument Grant Program (S10) provides groups of NIH-supported investigators funds to purchase or upgrade shared equipment costing up to $600,000. The High-End Instrumentation Grant Program is specifically designed to fund instrumentation that costs at least $600,000 with a maximum award of $2 million. Types of instruments supported include, but are not limited to, X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.

New this year: The Shared Instrumentation for Animal Research (SIFAR) Grant Program provides $20,000 to $750,000 to purchase or upgrade scientific instruments necessary to carry out animal experiments.

OHSU is not limited in the number of applications we may submit, provided the applications are for different types of equipment; however, internal review is required. A minimum of three major users who are PIs on active NIH research grants must be identified.

Internal coordination: To apply, you must submit a brief 1-3 page preliminary proposal to Sue Aicher, Ph.D., who is coordinating the review process, by Friday, March 17, 2017. External applications are due May 31, 2017. Your email should include the following:

1. What instrument will be requested, and why it is needed
2. Cost of the instrument, including vendor quote
3. Cost of maintenance contract
4. Where the instrument will be located
5. Major user group info (group of at least 3 scientists with qualifying federal funding at time of the award)
6. Institutional support

Proposals will be evaluated based on whether the instrument will enhance the proposal research, whether there is a good match between the proposal science and the requested instrument, the justification of need, the organization of the project, continuing commitment to the instrument, and the benefit to the overall research community.

Contact Sue Aicher for more information.

Career Dev. Opportunity for Patient-Centered Outcomes Research K12 Scholars

Applications are currently being accepted for the third class of patient-centered outcomes/comparative effectiveness research (PCOR/CER) K12 scholars (beginning Aug. 1, 2017). If you are a clinical, behavioral, health services, policy, public health, or applied junior faculty researcher interested in pursuing a research career in comparative effectiveness research applied to patient-centered outcomes, you may be eligible for this mentored K12 career development program.

The program provides 75% protected time for mentored research career development and includes training in patient-centered outcomes research, applied experience and training in research synthesis methods, as well as a significant mentored research experience. Scholars will receive salary support plus fringe benefits, and will be appointed as an OCTRI scholar.

See the Request for Proposal for details.

Please submit all application materials via OHSU’s Competitive Application Portal (CAP) by March 6, 2017.

If you have questions or would like more information, please contact Daniel Johnson or Jeanne-Marie Guise, M.D., M.P.H.

Core Resources Pilot funds help ready early ideas for extramural funding

Isolation of utricle hair bundles from Peter Barr-Gillespie's analysis of the proteome of hair-cell stereocilia. Ferracane’s new model draws on Barr-Gillespie's technique.

Isolation of utricle hair bundles from Peter Barr-Gillespie’s analysis of the proteome of hair-cell stereocilia. Ferracane’s new model draws on Barr-Gillespie’s technique.

Breakthrough innovation doesn’t happen overnight, and it doesn’t happen without money. OHSU Core Pilot Grants provide OHSU researchers with funds to develop new concepts or methods and to strengthen extramural grant proposals. The program is made possible by University Shared Resources, the School of Medicine, and the Office of the Senior Vice President for Research.

In 2016, the University Shared Resources pilot funds provided more than $200,000 for early research by 22 OHSU researchers. With this funding, a project by Jack Ferracane, Ph.D., professor and chair of the Department of Restorative Dentistry, was made ready for a competing continuation grant application to the National Institute of Dental and Craniofacial Research.

Ferracane’s work focuses on the structure, function, and clinical performance of dental restorative materials and his team has been developing antimicrobial and remineralizing dental materials containing bioactive glass to enhance the durability and longevity of dental restorations. The vast majority of adults and 60–90 percent of children are affected by tooth decay, making it a significant public health issue.

Until now, the rate of bacterial colonization in gaps in dental restorations compared to colonization on the surface of the same type of material has not been shown. Ferracane used a model that has never before been presented or tried to conduct novel experiments on the behavior of Streptococcus mutans bacteria on the surface of a restoration and within a small gap space. S. mutans is the main cause of dental decay and the challenge here was to collect enough protein to study differences in bacterial behavior at the protein level.

Ferracane, and his collaborators Kirsten Lampi, Ph.D., professor of Integrative Biosciences, and Justin Merritt, Ph.D., associate professor of Restorative Dentistry, worked closely with Larry David, Ph.D., and Ashok Reddy, Ph.D., director and associate director, respectively, of the Proteomics Shared Resource facility, to develop and test a methodology to recover and digest the small amounts of proteins present in the recovered bacterial biofilm. The team used the high-resolution Thermo Scientific™ Orbitrap Fusion™ mass spectrometer in the Proteomics Shared Resource to measure relative changes in protein abundance. Using Tandem Mass Tagging™ technology, the technique allows 10 individual samples to be simultaneously analyzed, increasing the speed and accuracy of the analysis.

Reddy and David worked closely with Ferracane, Merritt, and Lampi to develop and test a methodology to recover and digest the small amounts of protein present in the recovered bacterial biofilm. Their developed methodology used a combination of shearing the bacterial biofilm by intense shaking in the presence of glass beads (bead beating), followed by digestion with trypsin with the aid of ultrafiltration membranes.

Establishing the protocol took some trial and error, but demonstrated why having core facilities on campus is essential when establishing a new protocol like this. In this particular case, the use of ultrafiltration membranes to assist protein digestion was a technique borrowed from Peter Barr-Gillespie, Ph.D., professor of otolaryngology and associate vice president for basic research, who uses it when digesting extremely small samples of hair bundle proteins for proteomic analysis in the PSR facility. Reddy realized that combining the bead beating technique from Ferracane’s lab and the digestion method from Barr-Gillespie’s lab was the perfect solution to analyze very small samples of bacterial biofilms.

The new model successfully demonstrated that the rate of colonization was lower in the gap than on the surface of the restorative material. Additionally, the model was able to show that certain dental composites with ionreleasing properties show some inhibiting effect on bacterial colonization of gaps.

The University Shared Resources pilot funds, along with scientists and technology at the PSR, allowed Ferracane’s team to collect preliminary data sufficient to begin writing the NIH grant application and a manuscript for publication.

The pilot funds, launched in 2016, have supported 45 scientists with more than $360,000. University Shared Resources intends to begin the application process later this year for 2018 funding. If you have worked on a project made possible by the pilot funds, contact Andy Chitty to share your experience.

AstraZeneca open innovation seminar, Jan. 26

Academic researchers interested in partnering with industry are invited to an informational seminar hosted by OHSU Technology Transfer and Business Development with members from AstraZeneca. Information will be presented on AstraZeneca’s Open Innovation Program and future collaboration opportunities with OHSU.

OHSU researchers involved in the Open Innovation Program will enjoy access to resources ranging from optimized compounds and compound libraries to specialized technologies and know-how.

astrazeneca-oi-h3Thursday, Jan. 26
3–4 p.m.
Mackenzie Hall 3198

All are welcome to attend and no registration is required. For more information, contact Abby Dotson at dotsoab@ohsu.edu.

Applying for foundation funding? Check out the President’s List!

Just a friendly reminder that if you plan to submit a grant to a foundation or corporation on the OHSU President’s List, you are required to submit a Notice of Intent form to the OHSU Foundation. The purpose of the President’s List is to ensure that OHSU maintains coordinated communication with these organizations. Additionally, some organizations are reserved for top institutional priorities as determined by senior OHSU leadership.

Things to keep in mind:

  • If you’re interested in applying to one of these organizations, please submit a Notice of Intent form. The Notice of Intent Form is only required for organizations on the list.
  • If Office of Proposal & Award Management needs to contact one of these organizations or receives communications from them, please let someone on the Office of Foundation Relations team know.
  • The OHSU President’s List is updated about once a year.

Questions? Contact the OHSU Foundation.

OHSU researchers identify complex required for healthy brain

Brain phenotypes of Rcor1 and Rcor2 knockouts at E18.5.

Brain phenotypes of Rcor1 and Rcor2 knockouts at E18.5.

The intricately orchestrated series of events in nervous system development begins with the formation of neuroepithelial stem cells. These cells proliferate, creating progenitor cells that ultimately form neurons and the glia that provide support and protection for neurons. The balance of neurons and glia is fundamental to the development of a healthy brain.

Achieving the optimal neuron–glia balance depends on a delicate relationship between the proliferation of progenitors and the differentiation of neurons and glia. While it is thought that repressors and the corepressors that bind to them affect this relationship, repressor/corepressor complexes have not been shown in vivo.

A team of researchers from OHSU’s Vollum Institute has now identified, in embryonic brains of mice, a repressor/corepressor complex consisting of Insulinoma-associated 1 (INSM1), which halts the cycle of cell division, and the RE1 Silencing Transcription factor (REST) corepressors RCOR1 and RCOR2. The findings were published in the Proceedings of the National Academy of Sciences on Jan. 3, 2017.

The research, led by Gail Mandel, Ph.D., senior scientist at the Vollum Institute, with OHSU graduate student Caitlin Monaghan as first author, identified for the first time a repressor complex required for these critical transcription events that lead to the cessation of neural proliferation and therefore enable the production of proper numbers of differentiated neurons and glia. The findings demonstrated that an INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development. Eliminating either INSM1 or both RCOR1 and RCOR2 in the brains of mice significantly increased neural proliferation over differentiation of neurons and glia oligodendrocytes. The resulting abnormal brain morphology was restored when REST levels in the RCOR1/2-deficient brain normalized.

This research was supported by NIH grants NS022518, ULITR000128, NS093066, and DK09949. Other OHSU authors include Tamilla Nechiporuka from the Mandel lab, as well as Sophia Jeng and Shannon McWeeney from the Department of Medical Informatics and Clinical Epidemiology in the OHSU School of Medicine.

New NIH font guidelines go into effect Jan. 25

NIH has updated their recommended font list for applications submitted on or after Jan. 15, 2017. Following is a summary of guidelines that will apply to text in PDF grant application attachments:

  • Text color: Perhaps the most notable change, text in PDF attachments is no longer restricted to the color black. Though not required, black or other high-contract colors are recommended. Read: no fuchsia comic sans.  
  • Font size: Must be 11 points or larger. Smaller text in figures, graphs, diagrams, and charts is still acceptable as long as it’s legible when the page is viewed at 100%.
  • Type density: Must be no more than 15 characters per linear inch (including characters and spaces).
  • Line spacing: Must be no more than six lines per vertical inch.
  • Recommended fonts:  Arial, Georgia, Helvetica, Palatino Linotype. Other fonts are acceptable if they meet the above requirements. See the Font FAQs for additional guidance.

Still have questions? Learn more about formatting attachments here.

Nominate an OHSU colleague for Impact Awards: deadlines Jan. 1 and Jan. 16

Nominations for Impact Awards are being accepted now. You may nominate OHSU individuals or teams who are using innovative approaches to generate positive social or environmental change. Each year at the Elevating Impact Summit, PSU presents the awards to people behind breakthrough innovations. Teams can be an entire organization, a unit within an organization, or a less formal affiliation working together to achieve a similar goal. The 2017 Summit will be held on Feb. 13.

Health Innovation Award — Nomination deadline, Jan. 1
The Health Innovation award recognizes the achievements of an entrepreneur or entrepreneurial team working to address a health or healthcare related problem through the innovative application of business tools and approaches. Submit your nomination today.

Impact Invention Award — Nomination deadline, Jan. 16
The Impact Invention Award recognizes the achievements of an entrepreneur or entrepreneurial team working to address a social, environmental, or economic problem through an invention-based enterprise creating a new physical product or products. Inventions include novel devices or products created to solve a problem. Submit your nomination today.

Questions? Please contact Daphne Emerson Peters for more information.

 

LOIs for Circle of Giving funding due Friday, Jan. 6

This is a reminder to submit your letters of intent for the following funding opportunity: The OHSU Center for Women’s Health Circle of Giving is now accepting submissions for its 2017 Women’s Health Research Funding Opportunity. Prior to submitting an application, a letter of intent is first required. The letter of intent is due Jan. 6, 2017, and the application is due Jan. 20, 2017. Circle of Giving funding is intended to support new or established investigators interested in developing innovative directions in women’s health research.

Applications will be accepted from faculty at the rank of lecturer, assistant, associate, or full professor. Applications may be in basic science, clinical investigation, population health, or behavioral research. The pilot project conducted using these seed funds is expected to lead to additional research funded by federal and non-federal sources. The proposed research must be intended to produce a tangible improvement in women’s health.

The Circle expects to award $125,000 to support one project for one year. There may be opportunity for a second award this year.

Please view the full RFP for additional information. Applications must be submitted via OHSU’s Competitive Application Portal (CAP).

 

Welcome to the Research News Blog

Welcome to the Research News Blog

OHSU Research News is your portal to information about all things research at Oregon Health & Science University. Visit often for updates on events, discoveries, and important funding information.

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