2017 Biomedical Innovation Program Drug Discovery awards announced

Two drug discovery projects have been named recipients of the 2017 Biomedical Innovation Program awards. The awards program is a collaboration of the Oregon Clinical & Translational Research Institute, OHSU Technology Transfer & Business Development, and the Knight Cancer Institute. The awards provide funds, project management, and mentorship to facilitate the development of innovative technologies at OHSU and accelerate their translation to the marketplace. This track of funding supports drug discovery platforms and early stage therapeutic technology projects.

Monika Davare, Ph.D.

Monika Davare, Ph.D.

Monika Davare, Ph.D., an assistant professor of pediatrics in the OHSU School of Medicine’s Division of Hematology and Oncology, received an award to develop a ‘hit to lead’ compound as a therapeutic agent to treat Ewing’s sarcoma and subsets of hematological malignancies.

Professor Beth Habecker, Ph.D., and Associate Professor Michael Cohen, Ph.D., both from the OHSU Department of Physiology and Pharmacology, were awarded funding to develop novel compositions targeting protein tyrosine phosphatase sigma for nerve regeneration.

Beth Habecker, Ph.D., and Michael Cohen, Ph.D.

Beth Habecker, Ph.D., and Michael Cohen, Ph.D.

“OCTRI is proud to support these investigators and their important work furthering drug discovery at OHSU,” said David Ellison, M.D., director of OCTRI. “The Biomedical Innovation Program prioritizes commercialization outcomes to help develop technologies in ways that give them the best chance of successfully making it to the marketplace and improving human health. We are very excited to fund these projects for 2017, and look forward to working closely with the investigators.”

Detailed information on the Biomedical Innovation Program can be found on the OCTRI website.

Reproductive & Developmental Sciences Symposium: From Bench to Bedside

primateThe 2017 Annual Oregon National Primate Research Center Scientific Symposium is being hosted by the Division of Reproductive & Developmental Sciences. The symposium’s three hot topics are germ cell and embryonic development, fertility and in utero development, and fetal outcome and postnatal development.

2017 Annual ONPRC Scientific Symposium
Reproductive & Developmental Sciences: From Bench to Bedside

Friday, September 22, 2017
8:15 a.m. – 5:00 p.m.
Oregon National Primate Research Center
OHSU West Campus

Submit poster presentation abstracts by email (300-word limit) before August 18.

Registration is free and includes breakfast, lunch, and an optional tour of the Center. Space is limited — early registration is recommended.

Panels

GERM CELL AND EMBRYONIC DEVELOPMENT
Biology of genomic methylation patterns
Keynote speaker: Timothy H. Bestor, Ph.D., professor of genetics and development
College of Physicians and Surgeons of Columbia University
Presentations by the OHSU/ONPRC laboratories of Shawn Chavez, Ph.D.Shoukhrat Mitalipov, Ph.D., and Alison Ting, Ph.D.

FERTILITY AND IN UTERO DEVELOPMENT
Regulation of genomic imprinting in development and disease
Keynote speaker: Marisa S. Bartolomei, Ph.D., professor of cell and developmental biology
University of Pennsylvania Perelman School of Medicine
Presentations by the OHSU/ONPRC laboratories of Antonio Frias, M.D.Cadence True, Ph.D., and Leslie Myatt, Ph.D.

FETAL OUTCOME AND POSTNATAL DEVELOPMENT
Maternal pre-pregnancy metabolic condition; short and long-term effects on offspring
Keynote speaker: Patrick M. Catalano, M.D., director of the Center for Reproductive Health at Case Western Reserve University and director of Clinical Research at MetroHealth
Presentations by the OHSU/ONPRC laboratories of Peta Grigsby, Ph.D.Alejandro Lomniczi, Ph.D.Elinor Sullivan, Ph.D., and Nancy Haigwood, Ph.D. 

Conference contact: onprc-drds@ohsu.edu.

National Academies of Sciences, Engineering, and Medicine seeks input

na_nasem_logo_footerThe National Academies Next Generation Researchers Initiative Committee is soliciting feedback on actions that universities are taking to help successfully launch and sustain research careers in the biomedical and behavioral sciences.

The committee is seeking feedback on four core issues, including levels, sources and stability of funding; grant awards and review; training and mentoring; and underrepresented groups.

Submit your responses by October 1, 2017.

Study in Nature demonstrates method for repairing genes in human embryos that prevents inherited diseases

Gene correction in S-phase-injected human embryos.

Gene correction in S-phase-injected human embryos.

In a paper published in Nature today, August 2, 2017, Shoukhrat Mitalipov, Ph.D., reported the successful removal of a lethal genetic defect in human embryos.

Read the OHSU News story on Mitalipov’s new research.

The gene-editing technique described in this study could one day provide an avenue for people with known heritable disease-causing genetic mutations to eliminate the risk of passing the disease to their children. The study also demonstrated a way to overcome a crucial problem in genome editing. Known as mosaicism, the problem occurs when not all cells in a multicellular embryo are repaired and some cells still carry a mutation. These could ultimately find its way into an offspring’s DNA, rendering the repair moot.

The new study is the first to demonstrate that the technique can be used in human embryos to convert mutant genes back to normal.

The story behind the story

You may have seen some speculative reporting in the media about this research. OHSU honors our agreements with peer-reviewed journals to hold news of research until it is published. Two events made possible the premature media coverage. An individual not affiliated with OHSU, but familiar with the research, spoke without permission to a reporter. That reporter then found photos and video associated with the research that were briefly published prematurely on an OHSU website. Those images were removed and protocols have been changed to prevent this happening in the future. We worked closely with Nature to hold communications until publication of the paper, helping make possible thoughtful scientific writing about the paper.

Research advocacy update: Owen McCarty represents Oregon at the American Heart Association You’re the Cure event

The Oregon constituents of the American Heart Association You’re the Cure on the Hill 2017 meet with Congressman Earl Blumenauer.

The Oregon constituents of the American Heart Association You’re the Cure on the Hill 2017 meet with             Congressman Earl Blumenauer.

Owen McCarty, Ph.D.,FAHA, represented Oregon in a Washington D.C. research advocacy event in July. He joined a group of 330 advocates who met with 284 legislative offices as part of the 2017 American Heart Association You’re the Cure on the Hill. The team from Oregon included two patient advocates, Jane Staniford and Kellie Hill (pictured), as well as the Oregon AHA Director of Government Relations & Affairs, Christina Bodamer (left). They had a chance to meet with the offices of Congressman Earl Blumenauer, Greg Walden and Kurt Schrader and Senators Jeff Merkley and Ron Wyden. The focus of this year’s You’re the Cure was to advocate for an increase in funding for heart and stroke research from the National Institutes of Health and cosponsorship for the Furthering Access to Stroke Telemedicine (FAST) Act and Cardiac Rehab bills. McCarty is a professor and the interim chair of the Department of Biomedical Engineering in the OHSU School of Medicine.

 

Tracing the mechanisms of pain and empathy for pain

Representative photomicrographs of hM4Di viral expression, within the D) anterior cingulate cortex (orange) with DAPI in blue E) somatosensory cortex (orange) and DAPI in blue.

Representative photomicrographs of hM4Di viral expression, within the D) anterior cingulate cortex (orange) with DAPI in blue E) somatosensory cortex (orange) and DAPI in blue.

A new study finds a potential neural overlap between physically induced and socially transferred increased sensitivity to pain, or hyperalgesia. Previous research has shown that pain sensitivity associated with alcohol withdrawal can be communicated to nearby individuals by olfactory cues. But how this social transfer of pain occurs is not known.

Scientists at OHSU have now demonstrated that pain and empathy for pain activate partially overlapping regions of the brain in mice and that those experiences are reversed by inhibiting activity in one region of the brain—the anterior cingulate cortex. Monique Smith, Ph.D., led the research, published in eNeuro, which was conducted in the lab of Andrey Ryabinin, Ph.D., a professor of behavioral neuroscience in the OHSU School of Medicine.

The researchers first mapped changing activity in brain regions associated with pain and empathy for pain and then inhibited some of the activated brain regions. Brain activity of three groups of mice were monitored: primary mice with access to increasing concentrations of ethanol, bystander mice housed in the same room, and control mice housed in a separate room. The primary mice showed increased activity in the dorsal medial hypothalamus when access to alcohol was removed, which may indicate a role for this area in alcohol withdrawal. In contrast, bystander mice showed increased activity in the anterior cingulate cortex and insula. Inhibiting activity in the anterior cingulate cortex reversed hyperalgesia in both primary and bystander mice.

One important observation: The two forms of hyperalgesia in this study do not have a basis in tissue or nerve injury. Rather, the results confirm that withdrawal-related hyperalgesia can be socially transferred in mice housed together. These findings set the stage for research to determine if there are distinct circuits within the anterior cingulate cortex that govern physically induced and socially transferred hyperalgesia.

OHSU Commercialization Conference, Sept. 14

The signature conference of OHSU Technology Transfer and Business Development connects OHSU innovators, industry partners, investors, and community collaborators. The day includes startup pitches, insights from industry thought leaders, and successful collaboration stories.

In the first panel of the 2017 Commercialization Conference, Brian Druker, M.D., and four industry leaders will discuss breakthroughs that are transforming healthcare. Harry Glorkian from GE Ventures will moderate the panel that includes Druker, Brian Lawrence from global technology company Welch Allyn/Hill-Rom, John Hill from GE, and Sam Adams from IBM.

Register today
Thursday, Sept. 14, 2017
7:30 a.m. – 7 p.m.
Collaborative Life Sciences Building

What’s in store—some highlights:
Industry trends:

  • Executive panel: Breakthrough innovations transforming healthcare
  • Pharma’s transition from internal R&D to external collaborations
  • Role of molecular imaging in the modern era of medicine
  • Women’s contributions to innovation in science and business

Strategies for funding:

  • Drawing interest from VC’s and Angel investors
  • Alternative funding for innovation and startup companies

The 2017 slate of speakers includes two keynote speakers:

  • William Ruh, digital transformer and CEO of GE Digital
  • Gerry Langeler, venture capitalist and managing director of OVP Venture Partners

All OHSU faculty, researchers, students, and staff are welcome to attend. Speaker information and the full agenda can be found at the 2017 Commercialization Conference website.

2017 Mentor Award Nominations Deadline Extended to Sept.1

The Medical Research Foundation (MRF) of Oregon is seeking nominations for the annual Mentor Award.

The Mentor Award is presented to an Oregonian who has provided outstanding leadership in support or development of health research, education or the advancement of health care. The Mentor Award recipient will receive a cash award of $6,000 and a commemorative award.

The winner will be selected by the members of the MRF Committee. Guidelines, lists of past award recipients (eligible for renomination) and a list of current MRF committee members (ineligible for nomination) can be found at www.mrf-oregon.org.

Nomination must include:

  • A nomination letter clearly specifying the award for which the individual is being nominated and addressing how the individual meets the guidelines for that award.
  • The nominee’s curriculum vitae
  • No more than five letters of support. Letters of support signed by more than one person are discouraged.
  • Competitive nominations will include letters from outside your institution.

All documents should be submitted at one time, as one packet by the nominator.

Please send electronic submission (one pdf) to goodn@ohsu.edu.
Nomination deadline: 5:00 p.m. on September 1, 2017

The deadline for the Discovery and Richard T. Jones New Investigator awards has passed.

Questions?
Contact Nicole Good 503-552-0677 | goodn@ohsu.edu

 

North campus steam shutdown, Saturday, Aug. 5

A 17-hour steam plant shutdown will affect building heat, all hot water systems, and process steam to autoclaves in six north campus buildings. The shutdown is required for repairs to the steam plant and steam turbine connections. steam plant shut down

Steam supply to autoclaves will not be available during shutdown.

Buildings affected: Vollum Institute, Medical Research Building, Biomedical Research Building, Richard Jones Hall, Baird Hall, and MacKenzie Hall.

Saturday, Aug. 5, 2017 
5 a.m. – 10 p.m.

This shutdown is weather dependent. It could be postponed if a cold front is forecast.

If you have any questions, please contact Carl Gioia at gioiac@ohsu.edu.

 

 

Launching a portal to streamline research services at the DCM

Announcing a single portal for animal research: DCM Operations
The Department of Comparative Medicine will be transitioning to a web-based system for research-associated tasks. The centralized system is designed to improve the efficiency of DCM so that researchers can spend more time on research and less time on paperwork.

A platform that is familiar to the research community
The new system, DCM-OPS, is based on the same Huron Click™ platform as the IRB, IBC and IACUC systems. It also is integrated with IACUC protocols and serves as a single portal for animal care management.

comparative-medicine-bannerThrough the DCM-OPS portal, research staff will be able to:

  • Order animals
  • Initiate animal import, export, and transfer requests
  • Request DCM services (e.g., anesthesia machine rentals, drug and transportation requests, etc.)
  • Manage billing accounts
  • View monthly invoices

Training to precede rollout
Training on DCM-OPS will be delivered to research teams according to a rollout calendar. DCM will contact teams in the coming months to discuss the system transition. Be on the lookout for upcoming announcements and training events.

For questions regarding our transition to DCM-OPS, contact Dr. Tracy Gluckman at gluckman@ohsu.edu or 503-494-2477.

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