An HIV/AIDS vaccine candidate developed by researchers at Oregon Health & Science University appears to have the ability to completely clear an AIDS-causing virus from the body. In a paper published online today in Nature, the researchers show that 50 percent of monkeys given the vaccine were able to completely eliminate the monkey form of HIV. The researchers used a common, harmless virus called cytomegalovirus and modified it to carry genes for SIV proteins, the virus that causes AIDS in monkeys. The vaccine works by triggering a powerful, sustained immune response.
Louis Picker, M.D., associate director of the OHSU Vaccine and Gene Therapy Institute and lead author of the study, is hopeful that creating a modified version of the vaccine with HIV will yield similar results in humans.
To learn more, view of video of Dr. Picker discussing the findings or check out the OHSU news release.
This research was funded by several grants from the National Institutes of Health, funding from the International AIDS Vaccine Initiative and a CAVD grant from the Bill & Melinda Gates Foundation.