OHSU researchers produce world’s first chimeric primates

A chimeric embryo from Dr. Mitalipov's lab.

OHSU researchers, led by Shoukrat Mitalipov, Ph.D., associate scientist at the Oregon National Primate Research Center, have produced the world’s first chimeric monkeys, developed from stem cells taken from two different embryos. This is an important development, not because the researchers plan to develop human chimeras, but because the study reveals new information about different stages of embryo cells. For example, while cells from either early-or later-stage embryos can be combined to create a chimeric mouse, only later-stage embryos can be combined to create chimeric monkeys. While the researchers have yet to discover an explanation for this phenomenon, it may aid the process of translating lab findings to regenerative stem cell therapies for humans. Dr. Mitalipov’s findings will be published in an upcoming edition of Cell.

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