The OHSU Library is pleased to announce the online publication of the FDA Drug Approval Documents Collection. This collection contains review documents that led to the publication of the article “Selective publication of antidepressant trials and its influence on apparent efficacy” by OHSU’s Erick Turner, MD.
As stated in Dr. Turner’s article, “Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials–and the outcomes within those trials–can lead to unrealistic estimates of drug effectiveness and alter the apparent risk-benefit ratio.” According to ScienceWatch.com, this article was the tenth most highly cited scientific article published in 2008.
Dr. Turner is Assistant Professor in the Department of Psychiatry and the Department of Pharmacology at OHSU. He is also Senior Scholar with OHSU’s Center for Ethics in Health Care and Staff Psychiatrist with the Portland Veterans Affairs Medical Center.
Dr. Turner previously worked as a reviewer at the Food & Drug Administration (FDA). In that capacity, he became aware that drug companies were conducting studies that were not represented in the published literature. He procured Freedom of Information Act documents for his publication and arranged them in binders. The OHSU Library has scanned these documents and now offers them in a digital format.