Paper of the Month: Hemojuvelin’s role in regulating iron levels
September 2010′s School of Medicine News features “Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression” as its Paper of the Month. This month’s selection, published in the Journal of Biological Chemistry, is based on research by Mahta Nili, Doctoral Student, Ujwal Shinde, PhD, Associate Professor, and Peter Rotwein, MD, Professor, from the Department of Biochemistry and Molecular Biology.
The research demonstrates the effects of soluble naturally occurring hemojuvelin protein on several classes of BMP, which may have potential therapeutic uses, including treatment for juvenile hemochromatosis, a condition in which mutations in the body’s hemojuvelin cause excessive accumulation of iron in vital organs.
Read the entire Paper of the Month article on the School of Medicine website.
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