SOM Paper of the Month: Research shows how virus outsmarts immune system
In a recent publication, Louis Picker, MD, (left) and Klaus Früh, PhD, (right) explain the complex relationship between CMV and the human immune system.
June 2010’s School of Medicine News features “Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus” as its paper of the month. This month’s selection, published in Science, was led by Klaus Früh, PhD and Louis Picker, MD, both faculty members at the OHSU Vaccine & Gene Therapy Institute and Oregon National Primate Research Center.
In the paper, Drs. Früh and Picker, explain how a common herpes virus, cytomegalovirus (CMV), can outsmart the immune system, even when a person is otherwise healthy. While this means it may be difficult to create a vaccine to prevent CMV, which can cause serious problems for infants, organ donor recipients, and HIV patients, the research suggests that the CMV virus could be manipulated to induce immunity against other hard-to-immunize infections, such as HIV/AIDS.
Read the entire Paper of the Month article on the School of Medicine website.
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