Mentored career development program in women’s health, applications due Nov. 3

The Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 program has announced a mentored career development opportunity for OHSU junior faculty members interested in interdisciplinary women’s health research. Potential clinically prepared applicants can propose projects across the full spectrum of research including basic science, clinical research, information technology, health services, patient-centered outcomes, policy, public health, behavioral and applied science. In addition to salary support (75% FTE up to $95,000), and travel and research funds of up to $25,000 per year, awardees will be appointed as OCTRI scholars, gaining access to a variety of core OCTRI services.

To be eligible, applicants must be U.S. citizens, non-citizen nationals or individuals lawfully admitted for permanent residence (by November 3, 2014) who hold a clinical or health professional doctoral degree or its equivalent and have no more than six years of research or research training experience beyond their last doctoral degree. The applicant must commit a minimum of 75% full-time professional effort to conducting women’s health research, have identified mentors with extensive research experience, and must NOT be a PI on an R01, R29, program project, center, or K award. The applicant’s department must agree to commit at least $10,000 per year in discretionary funds to the scholar, if appointed, which is matched by the institution with $15,000 per year toward the scholar’s research projects and training. This is an interdisciplinary research training program and as such scholars must have multiple mentors who represent different disciplines.

Applications due November 3, 2014.

Invention, innovation & commercialization: OCTRI Biomedical Innovation Program Funding Q&A session, Oct. 13

OCTRI will be holding an informational Q&A session for the Biomedical Innovation Program Award, hosted by Eric Orwoll, M.D., Monday, October 13, 2014. This session is strongly recommended for those thinking about applying before the November 14th deadline. Current RFA and full opportunity information can be found here.

Biomedical Innovation Program Award Q&A session
October 13, 2014 at 12pm
Mac Hall, rm 1162

Bench-to-beside device, diagnostic, and software development is the focus of OCTRI’s Biomedical Innovation Program. Formed in partnership with Technology Transfer & Business Development in 2012, the Biomedical Innovation Program has funded a total of nine projects, led by a diverse group of principal investigators, including clinicians, scientists, and bioengineers. Several of these projects have reached proof-of-concept as a result of this funding and are being actively marketed by Technology Transfer & Business Development for licensing agreements with biomedical corporations or have formed the basis for start-up companies.

Questions? Please contact Jonathan Jubera.

For more information about OCTRI Awards and the Biomedical Information Program please visit the OCTRI Funding Opportunities page.

Applications for Burroughs Wellcome Fund Preterm Birth Initiative due Dec. 1

The Burroughs Wellcome Fund Preterm Birth Initiative offers up to $600,000 over four years to both creative individual scientists and multi-investigator teams to approach the problem of preterm birth using creative basic and translation science methods. Molecular and computational approaches such as genetics/genomics, immunology, microbiology, evolutionary biology, mathematics, engineering, and other basic sciences hold enormous potential for new insights independently or in conjunction with more traditional areas of parturition research such as maternal fetal medicine, obstetrics, and pediatrics. The formation of new connections between reproductive scientists and investigators who are involved in other areas will give preterm birth research a fresh and unique look, and stimulate a new workforce to tackle this challenge.

Proposals must be submitted from degree-granting institutions in the U.S. or Canada. The PI must be a postdoctoral fellow in the final 1-2 years of postdoctoral training or hold a faculty appointment (assistant/associate/professor-level status) at a degree-granting institution in the U.S. or Canada. The PI must be a citizen or permanent resident of the U.S. or Canada. Proposals should address the biomedical causes and molecular mechanisms underlying (preterm) parturition including but not limited to peri-implantational events, placentation, fetal determinants, fetal-maternal immune responses, biological basis for racial-ethnic disparities, mechanisms relating preterm birth to other adverse pregnancy outcomes, biology of normal labor, genomics, evolutionary influences and other approaches. Proposals seeking to identify biomarkers predicting preterm birth are welcome. Postdoctoral fellows nearing their transition to independent investigator status through senior established investigators are encouraged to apply.

Applications due December 1, 2014.

Reminder: register for the 2014 TTBD Awards, Oct. 6

The office of Technology Transfer & Business Development invites the OHSU community to attend the 2014 TTBD Awards Ceremony. Awards will be presented to OHSU community members for their collaborations and efforts in licensing, sponsored research, patenting, and entrepreneurship. In addition, top honors will be awarded in the categories of New Inventor of the Year, Business Development Partnership, Technology Transfer Achievement, and TTBD Appreciation.

Monday, October 6, 2014
Collaborative Life Sciences Building, PSU Lecture Hall, First Floor
5:00-8:00 PM
Drinks and hor d’oeuvres will be served at the opening reception starting at 5 PM. Ceremony will begin promptly at 6 PM. 

Please join TTBD for this special event to support your colleagues and to learn more about innovation and entrepreneurship at OHSU. Register here to attend 2014 TTBD Awards ceremony.

Collaboration in Collaborative Life Sciences Building yields hypertension breakthrough

David Ellison, M.D., professor of medicine at Oregon Health & Science University and staff physician at the Portland VA Medical Center, leads a group that has been studying causes of human hypertension. In a paper published September 24th in the Journal of Clinical Investigation, “Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3”, the group identified a novel and unexpected mechanism for this hypertensive disease.  This research was done in collaboration with groups in Mexico City and Berlin, and here in Portland with Portland State University, a partnership formed through the new Collaborative Life Sciences Building. This work was led jointly by Dr. Jeffrey Singer from Portland State University.

ellison, singer and mccormick

Jeffrey Singer, James McCormick and David Ellison in the lab

According to the Centers for Disease Control and Prevention, about one in three adults in the U.S.—or 67 million people—have high blood pressure. This common condition increases the risk for heart disease and stroke, two of the leading causes of death for Americans. While physicians have a number of medications that are used to treat hypertension, often successfully, overall control rates remain poor, medication costs are high, and side effects are common.

Only five percent of patients develop hypertension from known causes with a staggering 95% from unknown causes, and nearly all treatment is empirical. Therefore the researchers focused in on the known causes, rare familial (single-gene) causes of hypertension, in order to possibly illuminate therapies that can impact the broader causes of the disease.

The researchers focused on the mechanisms behind salt transport in the kidneys because a proven cause of hypertension is excess salt. This led the researchers to study single gene mutations that provoke salt transport in the kidneys in a form of hypertension with known causes, in this case the genetic condition familial hyperkalemic hypertension (FHHt).

Dr. Ellison and his colleagues ultimately found that eliminating this gene in the kidneys not only did not mimic FHHt, but also caused kidney damage. Instead that found that the gene mutations actively degrade proteins in the kidney that help to eliminate kidney salt transport.  This conclusion leads to two new pathways for research.  First, it identifies a new target for blood pressure drug development, and second, it illuminates an unknown mechanism for kidney inflammation, one that likely contributes to chronic kidney disease, and likely to cancer.

Read the full paper here

OHSU Study shows 63% drop in uninsured Oregonians

A study released September 18 shows that the number of uninsured Oregonians fell by 63 percent from June 30, 2013 to June 30, 2014. Researchers at OHSU and the Oregon Health Authority  assessed whether policy changes associated with the Affordable Care Act changed the number of uninsured Oregonians. Support for the study was provided by the Oregon Health Authority and by the Robert Wood Johnson Foundation’s State Health Reform Assistance Network.

James D. Ross, Ph.D., DAF: Aortic Occlusion Systems: Potentially Powerful Tools, Significant Risk? – 9/25

James D. Ross, Ph.D., DAF, Air Force Medical Service and Director of the Air Force Trauma and Resuscitation Research Program, Joint Base San Antonio – Lackland, will present his talk, “Aortic Occlusion Systems: Potentially Powerful Tools, Significant Risk?” on Thursday, Sept 25th, 4 p.m., Mackenzie Hall 3198.

Dr. Ross is a translational science expert in trauma and hemorrhage. He joined the Naval Medical Research Unit, San Antonio in 2010 as a Senior Research Physiologist for Combat Casualty Care and eventually became the Deputy Department Head of the CCC Research Program. In 2012, Dr. Ross was selected as the GS-15 Director of Trauma and Clinical Care Research for the 59th Medical Wing at the Wilford Hall Ambulatory Surgical Center and the Battlefield Health and Trauma Research Institute.

HHMI International Student Research Fellowships; internal LOI due Oct. 17

The Howard Hughes Medical Institute (HHMI) seeks applications from outstanding international pre-doctoral students studying in the U.S. who are ineligible for fellowships or training grants through U.S. federal agencies. The HHMI International Student Research Fellowship program funds three-year fellowships for international graduate students worth over $30,000 per year. The fellowships are intended to support years three, four, and five of a Ph.D. program. HHMI seeks fellows in the following biomedical-related fields: biology, chemistry, physics, math, computer science, engineering, plant biology, and interdisciplinary research.

To be eligible, applicants should currently be in the second (or third) year of graduate study, have entered a laboratory in which they will conduct their dissertation research, and not be citizens, non-citizen nationals, or permanent residents of the U.S.
Please note
:
This opportunity requires internal coordination since OHSU may only submit a limited number of applications . If you intend to apply, please complete a limited submission form before October 17, 2014.

Look for other current funding opportunities.

Research Administration classes this fall: RDA 101

Research Administration Training & Education (RATE) is offering a number of great classes in the next few months for Research Administrators and others who support Research at OHSU. See the schedule of classes here. There are still spots available in this week’s class:

Wednesday, September 24  RDA 101: Introduction to Research Administration

9:30 a.m. to 11:30 a.m., Bancroft Building Community Room

Whether you’re new to OHSU Research or have been around but would like to put some faces to names, or fill in gaps, join us as we take a big-picture look at Research Administration. Meet RDA unit leaders, tour valuable web resources, and say hello to your contacts in SPA, RGC, IRB, etc.

Contact Margaret Gardner to reserve your seat or for any other questions about this.

IRB Notes eIRB Helpdesk: Top Tips for IRB Submissions

1. I need to add or remove a staff member on my eIRB study. What’s the best way to do this?

You should submit staff changes independent of other changes to your study. Normally, staff-only modifications can be turned around within 24 hours, allowing your change to take effect quickly. If you pair this change with other items, the staff has to wait for the approval of the entire modification.

2. I am trying to add someone to my eIRB study, but I am not finding them in the search. What gives?

Chances are one of two things has happened. First, double check that the person has registered for the eIRB. Simply taking the Big Brain courses doesn’t create an eIRB account. If someone needs to register, they can find the “Registration” link at the bottom left of the eIRB login page. If they’ve already registered for the eIRB, check that you are spelling their name correctly. The eIRB is connected to the HR database, so you must use the person’s name as it appears in HR’s records.

3. I am adding someone to my eIRB study, and I am getting an error message that they are not compliant with the required Big Brain trainings and / or Conflict of Interest. I think they have two Big Brain accounts; what do I do?

You can handle this one of two ways. First, you can email your request, and the person’s full name, to oioeduc@ohsu.edu. Second, you can call us to have the person’s account updated. Once the multiple accounts are merged, the system updates overnight, and you’ll be ready to submit!

Welcome to the Research News Blog

Welcome to the Research News Blog

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