Major changes to NIH and AHRQ grant resubmission policy that will make your life easier and better

Few things are as frustrating as writing a great grant that is not funded because the funding percentile is so low–and then having to figure out how to drastically revise it to meet the requirement of writing a “new” application. Effective now, that pain point is going away: As of April 17, 2014, the NIH and AHRQ no longer require new (A0) grant applications to demonstrate significant changes in scientific direction, even if the project was not funded during resubmission (A1). That is, if your project doesn’t get funded after the second try, you no longer need to ditch it and come up with something completely different.

If you are submitting a project as a new (A0) application, you will not be able to explicitly respond to reviewer comments, and reviewers will be instructed to respond to it as a new idea. However, the NIH recommends that applicants take advantage of reviewer comments and use them to make their applications stronger.

Duplicate or overlapping applications are still not accepted. View NOT-OD-14-074 for more information, and check out what Sally Rockey has to say. In the meantime, we will be mulling over the implications of this change. Stay tuned!

Peter Barr-Gillespie, Ph.D., appointed associate vice president for basic research

Dr. Barr-Gillespie

Dr. Barr-Gillespie

Senior vice president for research Daniel M. Dorsa, Ph.D., is pleased to announce the appointment of Peter G. Barr-Gillespie, Ph.D.,  as associate vice president for basic research.

Dr. Barr-Gillespie has been with OHSU since 1999. After undergraduate studies at Reed College, Barr-Gillespie attended graduate school at the University of Washington, working with Joe Beavo; he received his Ph.D. in Pharmacology in 1988. From 1988 to 1993, he worked as a postdoc with Jim Hudspeth, first at UCSF, then at the UT Southwestern Medical Center. He joined the Department of Physiology at Johns Hopkins University as an assistant professor in 1993, becoming associate professor in 1998. In 1999, he joined the Vollum Institute and the Oregon Hearing Research Center as an associate professor of otolaryngology; he was promoted to professor of otolaryngology in 2004. In 2012, Barr-Gillespie was named director of the Hearing Health Foundation’s Hearing Restoration Project (HRP), a consortium of scientists who are developing a strategy for regeneration of sensory hair cells of the inner ear. Barr-Gillespie’s own research focuses on mechanotransduction by hair cells; the lab uses proteomics, genomics, molecular biology, imaging, and electrophysiology to understand how molecules of the hair cell, many of which can be disrupted in genetic deafness, come together to form an extremely sensitive and selective sensory receptor.

In his role as associate vice president for basic research, Dr. Barr-Gillespie will help to guide Dr. Dorsa in operational and strategic areas in the research mission. He will work closely with his counterpart, Eric Orwoll, M.D., the associate vice president for clinical and translational research and director of the Oregon Clinical & Translational Research Institute. Dr. Barr-Gillespie says that in spite of the challenges of the current scientific environment, he remains an optimist: “Modern biomedical research has had astounding successes, and the continued evolution of ideas and technology has produced a remarkable understanding of the basic biology underlying cellular and organ physiology. Because of these successes of basic science, there is more promise than ever for disease therapies. This position will provide an outstanding platform for shepherding OHSU’s growing excellence in basic science, and I am pleased to participate in the institution’s response to the challenges of the present environment.”

Jungers Center for Neurosciences Research Symposium, May 13

The 6th Annual Jungers Center Symposium, “The Genetics and Genomics of Neuropsychiatric Diseases,” will be taking place from 9 a.m. to 12 p.m. on Tuesday, May 13, 2014 in the Doernbecher Vey Auditorium. This year’s speakers include:

  • James Lupski, M.D., Ph.D., from the Baylor College of Medicine, on “Merging human genetics and genomics: From genes to genomes, rare variants and clan genomics”
  • Stephan Züchner, M.D., Ph.D., from the University of Miami, on “From new tools to discovery: the contribution of rare genomic variation to disease”
  • Kári Stefánsson, M.D., Dr. Med., from deCode Genetics, Reykjavik, Iceland, on “The use of genetics to explore functions and dysfunctions of the brain”

Admission to the event is free and open to the public. Contact Ruth Frank with any questions.

Leading DOHaD researcher to give Research Week keynote, May 8

Chittaranjan Yajnik, M.D., FRCP, an international expert in the field of developmental origins of disease, has been invited by the School of Medicine Research Roadmap Task Force #6 and the Knight Cardiovascular Institute Center for Developmental Health to give a lecture during Research Week on Thursday, May 8, from 12 to 1 p.m. in the OHSU Auditorium. Dr. Yajnik will lead us in a conversation about the rapidly rising epidemic of diabetes and non-communicable diseases in India, examining conventional explanations and the application of the developmental origins of health and disease (DOHaD) theory, using examples stemming from multi-year intervention studies.

Dr. Yajnik founded KEM Hospital’s diabetes unit in 1985. He has worked for the last three decades to investigate the high susceptibility of Indians to diabetes, popularizing the concept of thin-fat Indians and leading research studies related to the developmental origins of diabetes and cardiovascular disease. He is featured in a BBC program, The Nine Months That Made You, which has been shown across the globe, and is the recipient of the Hellmut Mehnert Award of the International Diabetes Federation (2009) and the David Barker Medal of the DOHaD society (2011), honoring his contributions to the scientific development and broader leadership of the DOHaD field.

This talk is one of four keynote lectures during OHSU Research Week, taking place May 5-9. View the full Research Week schedule.

School of Dentistry Dean’s Seminar Series: Jeffrey Ebersole, Ph.D., April 29

For the fourth installment of the Dean’s Seminar Series, the School of Dentistry will host speaker Jeffrey Ebersole, Ph.D., professor and associate dean for research and graduate studies, Center for Oral Health Research, University of Kentucky College of Dentistry.  Dr. Ebersole’s presentation will focus on “Macrophage Plasticity and Phenotypes Related to Periodontitis.”

All are invited to attend this seminar starting a 12:30 p.m. on Tuesday, April 29 in the School of Dentistry room 220/225. A reception will be held at noon in front of the lecture room.

About the Dean’s Seminar Series

“The Dean’s Seminar Series is an excellent initiative,” said Harjit Singh Sehgal, B.D.S., M.S., F.A.G.E., assistant professor of periodontology, School of Dentistry. “It clearly provides an avenue to bring in distinguished speakers from different dental disciplines, research or service, and extends an opportunity for exchange of ideas, fosters collaborative research, and helps us effectively seek our institutional vision.”

“The seminars are also a great source of motivation for students and faculty.”

Continuing education credit is available for this free lecture.

eCRIS User Group Meeting, April 28

eCRIS logoStudy coordinators and clinical researchers are invited to the first quarterly eCRIS user group meeting on Monday, April 28, 2014 from 3 to 4 p.m. in CHH 3rd floor room 1A/B. Participants will hear about upcoming enhancements to eCRIS, be able to provide feedback, and learn different approaches to handling pre-award activities in eCRIS.

Refreshments will be provided. Questions? Contact eCRISSupport@ohsu.edu.

2014 Matarazzo Lecture: Fred H. Gage, Ph.D., May 5

Dr. Gage

The Department of Behavioral Neuroscience invites you to its 2014 Matarazzo Lecture and Reception featuring guest speaker Fred H. Gage, Ph.D., a professor at the Laboratory of Genetics at The Salk Institute for Biological Studies. This year’s lecture, “Mobile Elements: Generation of Behavioral and Evolutionary Diversity,” will be held at the Vey Conference Center on the 11th floor of the Doernbecher Children’s Hospital on Monday, May 5 at 1 p.m. The lecture will be directly followed by a reception with hor d’oeuvres and drinks.

An RSVP is appreciated – to do so, please contact Nicole Ernst.

About the speaker

Dr. Gage concentrates on the adult central nervous system and the unexpected plasticity and adaptability to environmental stimulation that remains throughout the life of all mammals. Gage’s lab showed that, contrary to accepted dogma, human beings are capable of growing new nerve cells throughout life. Small populations of immature nerve cells are found in the adult human brain, a process called neurogenesis. Gage is working to understand how these cells can be induced to become mature functioning nerve cells in the adult brain and spinal cord. They showed that environmental enrichment and physical exercise can enhance the growth of new brain cells and they are studying the underlying cellular and molecular mechanisms of neurogenesis.

This lecture series honors the founder of the Department of Behavioral Neuroscience, Joseph Matarazzo, Ph.D., who in 1957 established the OHSU Division of Medical Psychology. Four years later, the division was converted into a basic science department, thus establishing the first Department of Medical Psychology within a medical school in the U.S. The department warmly recognizes the dedication and insight provided throughout the years by Joe.

Save the date: Career networking night with OHSU alumni, May 6

Join more than 20 OHSU alumni for a special networking night focused on non-academic career paths for Ph.D. candidates and postdoctoral fellows. Students, faculty, and postdocs are welcome to visit with OHSU alumni and learn from their experiences in career paths outside academia. Hors d’oeuvres and cold beverages provided.

Career networking night
Tuesday, May 6, 2014 from 5:30 to 7:30 p.m.

Richard Jones Hall Atrium

This OHSU Research Week event is sponsored by the School of Medicine Alumni Association.

Multiple K12 junior faculty career development opportunities available

Patient-Centered Outcomes Research K12 Scholars
Up to five K12 scholar opportunities are available for junior faculty conducting clinical, behavioral, health services, policy, public health, or applied research. This mentored career development program features three core elements: a didactic education in patient-centered outcomes research, an individualized experiential plan, and a significant, mentored research experience. To be eligible, scholars must be U.S. citizens, non-citizen nationals, or permanent residents and cannot be applying for or have received another career development grant or research award of over $100,000 in direct costs per year. Scholars will receive salary support for a minimum of 75% FTE up to a maximum of $90,000, plus applicable fringe and $25,000 per year for research, supplies, and travel. Proposals are due May 30, 2014 for a minimum two-year appointment with an anticipated start date of August 1, 2014.

Career Development Award in Women’s Health Research
The BIRCWH (Building Interdisciplinary Research Careers in Women’s Health) K12 program at OHSU has openings for junior faculty members interested in interdisciplinary women’s health research. Potential clinically prepared applicants can propose research across the full spectrum of research, including basic science, clinical research, information technology, health services, patient-centered outcomes, policy, public health, behavioral, and applied research. To be eligible, scholars must be U.S. citizens, non-citizen nationals, or permanent residents and must not be a PI on a R01 or K award. Scholars will receive salary support and OPE for a minimum of 75% FTE up to a maximum of $95,000 (salary + fringe), and up to $25,000 per year for research, supplies, and travel. Proposals are due June 9, 2014 for a two-year appointment starting October 1, 2014.

Students and Postdocs: Send in your ugliest data by April 25!

Do you have an unfortunate set of data? A photo of a lab “fail”? Or a particularly ugly figure? Now’s your chance to turn that ugly data into a new iPad Mini!

During Student Day at OHSU Research Week, attendees will vote for the ugliest data. You no doubt have some ugly data in your notebooks or on your computer, and every field is bound to specialize in its own unique style of ugly. So submit your data, and let’s have a laugh at our own mistakes!

Here’s an example from Kelly Chacón, a graduate student in Environmental Health.

To submit, put your data onto a single PowerPoint slide. Add a caption explaining what’s so ugly about it and send to funding@ohsu.edu by Friday, April 25. We can’t wait to see what you come up with.

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