Image of heart muscle cells proliferating
In a paper published March 4 in Nature Communications, coauthored by Lincoln Shenje, M.D., Ph.D, assistant professor at the OHSU Knight Cardiovascular Institute, researchers describe the first found gene mutation in humans that causes heart muscle cells to proliferate beyond birth. This mutation was discovered in a rare syndrome called ALMS1 that has been reported in less than 70 people in the past 50 years worldwide.
According to Dr. Shenje and colleagues, this discovery goes against widely accepted dogma that we have a finite number of heart muscle cells in our lifetimes. This finite number is especially problematic in post-heart attack patients that have lost enough heart muscle cells to initiate irreversible heart failure. Dr. Shenje began research on this project at Johns Hopkins and continued this line of work when he arrived at OHSU last summer. His laboratory at OHSU aims to study this mutation in order to develop therapies that stimulate heart muscle cells to regenerate after a heart attack in order to prevent heart failure, essentially creating a regenerating heart.
Oregon Health & Science University has just announced a new Center for Embryonic Cell and Gene Therapy to be led by Shoukhrat Mitalipov, Ph.D., senior scientist at OHSU’s Oregon National Primate Research Center and world leader in embryonic stem cell and gene therapy research.
In May 2013, Dr. Mitalipov and his colleagues received significant attention after publishing a paper in Cell describing a new process for creating human embryonic stem cells from skin cells. The discovery was named a top 10 scientific breakthrough of 2013 by several international publications because of the promise it holds for treating Parkison’s disease, cardiac disease, spinal cord injuries, and other conditions.
Most recently, Dr. Mitalipov traveled to Maryland last week for a highly-publicized Food and Drug Administration hearing that reviewed the potential for moving gene therapy research into human clinical trials. Dr. Mitalipov and his team succeeded in preventing transmission of genetic defects in mitochondrial DNA in the cells of monkeys, in 2009, and in human cells in 2012. The next step, he says, is to test the procedure in humans.
Leaders at OHSU say that the new center will allow for expansion of private funding, which is critical because federal funding for human embryonic stem cell research is restricted.
“This center will give them a new foundation that will boost them to new levels of scientific discovery, and allow them to continue to lead for years to come,” said Dan Dorsa, Ph.D., senior vice president for research at OHSU.
Now is the time to reserve your spot in this spring’s Essentials of Grant Administration class!
Whether you’re new to grant administration or interested in learning about the most current practices and resources relating to federal grant funding, this course is for you. It’s also the centerpiece of Research Administration Training & Education’s Essentials of Grant Administration Certificate Program.
A variety of topic experts in the OHSU Research mission help to paint the “big picture” as we address the lifecycle of a grant from the very first steps of finding funding all the way to publishing and account close-out. Walk with us through frequent concerns, case studies, and rich discussions so that you leave ready to meet your department’s specific needs.
This course is intended for anyone who supports, coordinates, oversees, or otherwise engages in the administration of federally funded research grants. We meet for three consecutive Tuesdays from 1 p.m. to 4 p.m. starting March 25, 2014. You’ll find more details on the RATE Community site.
Register now by logging in here with your network credentials. Questions? Contact Margaret Gardner.
Wondering how Epic (the system OHSU uses for electronic medical records) might be used to answer your research questions? Come learn what Epic has to offer to researchers and how to access it. This seminar will be led by Robert Schuff, M.S., director of Clinical Research Informatics at the Oregon Clinical and Translational Research Institute.
Tuesday, March 18, 2014
12 p.m. to 1 p.m. in Mac Hall 2201
The HIP Buffet Series, sponsored by the Human Investigations Program of the Oregon Clinical and Translational Science Institute provides a forum on various topics in clinical and translational research. The HIP Buffet is targeted to all faculty, clinical and basic science postdoctoral fellows, research-ranked employees, and staff who are interested in a clinical and translational research career. Learn more about the Human Investigations Program at www.ohsu.edu/hip.
The Awards Program is a key part of the Oregon Clinical & Translational Research Institute (OCTRI). OCTRI offers a variety of award mechanisms all aimed at stimulating new external funding at OHSU. Since 2007, 108 OCTRI awards have been launched, and of those projects 42 have resulted in at least one new external research award, with many receiving more than one award. A total of 81 external grants have been credited to OCTRI pilot support, bringing in $52.8 M in new OHSU funding. The Catalyst Award program is a partnership between OCTRI and the SOM Research Roadmap.
Don’t miss out!
OCTRI will be holding an Informational Q&A session for their largest funding opportunity, the Catalyst Award, Tuesday, March 11, 2014. This Q&A session will be held at 10 a.m., in Mac Hall room 2201, and is strongly recommended for those thinking about applying for the 2014 deadline.
Please RSVP to Colleen Lay.
The Catalyst award is designed to support the development of funding proposals in three general areas: large, transdisciplinary grants (e.g. Center, PPG or multi-investigator R01s), grants that support the development of research cohorts that can themselves be platforms for multiple research projects, and grants to initiate programs designed around first in human studies. Projects can request up to $100,000 of direct costs and an additional $25,000 for OCTRI services.
For more information about OCTRI Awards and the Catalyst Q&A session visit the OCTRI Funding Opportunities page.
Register for the Spring Vollum Writing Course, a 6-week professional science writing course open to OHSU graduate students, postdoctoral fellows, and junior faculty.
This class uses short lectures, class discussion, and workshop-style writing assignments to help researchers learn to write better papers and grants. Topics include:
- The basic elements of good scientific writing style, including sentence and document structure;
- Insight into scientific conventions regarding grammar, punctuation, and usage;
- Strategies for revising;
- Dealing with writer’s block and time management;
- Best practices for writing introductions, results, discussions, and grant proposals.
The class runs for six weeks, from 9:30 a.m. to 12 p.m. on Wednesdays, beginning April 2, 2014. Six individual tutorials with the instructor are included. There are no prerequisites for this noncredit, professional development course, but you should not take the class unless you have enough data to write about.
The course carries a fee of $500 per student (unless you are in a Vollum lab or part of select graduate Ph.D. programs). Questions? Contact Rachel Dresbeck, Ph.D.
Register for the Vollum Writing Program.
The deadline to submit an abstract to present at OHSU Research Week has been extended to Monday, March 10.
All OHSU students, faculty, fellows, and research staff are invited to submit an abstract for either a 10-minute oral or poster presentation. Research Week is a great opportunity to practice your presentation skills and meet colleagues from different departments and programs. Abstracts that have previously been presented at other meetings may be submitted for Research Week.
- Oral presentations will be grouped into symposia by category, Monday through Thursday, May 5-8. Researchers of all levels may present within the same session. Limited space is available for students to present in a student-only session on Tuesday, May 6. Each speaker has 10 minutes to present and 5 minutes at the end for questions.
- Poster sessions will take place Monday through Thursday in the Old Library Great Hall and Richard Jones Hall Atrium. Poster dimensions are limited to 4′x6′.
Visit the Research Week Call for Abstracts page for complete instructions on how to submit.
We have a fantastic lineup of keynote presenters for Research Week this year, including Gary Gibbons, M.D., director of the National Heart, Lung, and Blood Institute (NHLBI); Jeff Lichtman, M.D., Ph.D., professor of molecular and cellular biology at Harvard University; Jim Austin, Ph.D., editor of Science Careers, a publication of Science magazine and AAAS; and Chittaranjan Yajnik, M.D., director of the diabetes department at KEM Hospital Research Centre, an international expert in the field of developmental origins of disease. More information about programming coming soon.
Also of interest
Have you ever considered traveling abroad to pursue your research career goals? Maybe you’ve wondered if a new environment might allow you to gain alternate perspectives? Or perhaps you just want to see more of the world? If so, you won’t want to miss this month’s Funding Focus featuring special guest from the Fulbright Program, Dylan Gipson, senior program officer for the Fulbright Council for International Exchange of Scholars, who will present on March 25, 2014 at 3 p.m. in the Vollum Auditorium, room M1441 (if you’re a Funding Focus regular, you’ll notice this event is being held at a special date/time).
This is a great opportunity for faculty and postdoctoral fellows to learn more about the Fulbright Scholar program and gain insight into how to assemble a competitive application. In addition to his presentation, Mr. Gipson will also be available immediately afterward to discuss with potential applicants their project proposals and specific world regions of interest.
Read more about the Fulbright Scholar Program on the official website.
Have questions about this event? Email firstname.lastname@example.org.
Prepare for OHSU Research Week by attending this lunchtime seminar on “How to Give a Scientific Talk,” presented by Allison Fryer, Ph.D., associate dean for Graduate Studies in the School of Medicine, and Cynthia Morris, Ph.D., professor and vice chair of medical informatics and clinical epidemiology, and professor of medicine and public health and preventive medicine.
This workshop is recommended for both Research Week oral presenters as well as Three-Minute Thesis competition participants. Drs. Fryer and Morris will cover how to give both a 10-minute and 3-minute scientific presentation. All are welcome.
Workshop: How to Give a Scientific Talk
Tuesday, March 11, 2014
12 to 1 p.m. in Mac Hall 1162
This event is sponsored by Research Week, OHSU’s university-wide celebration of research, May 5 – 9, 2014. Questions? Contact email@example.com.
Thursday, March 20, 2014
11:30 a.m. to 12:30 p.m.
The newly streamlined Initial Review Questionnaire, or IRQ, is rolling out in early March. This session, lead by OHSU Institutional Review Board analysts, will give you an in-depth tour of the changes and provide guidance on how they affect the rest of your IRB submission. Bring your questions!
Learn about other changes to initial submissions in eIRB.