Aggressive prostate tumors can rapidly evolve to resist PARP inhibitors, but it may be possible to detect resistance early enough to counteract. Two views of the structure of the DNA-repair protein PARP1 It was a surprising discovery that opened up a new avenue for treating prostate cancer. In recent years, studies have revealed that gene mutations long associated with breast and ovarian cancers – BRCA1 and BRCA2 – also play a significant role in driving … Read More
Posts Tagged ‘prostate cancer’
Men with prostate cancer became more vulnerable to falls if they used androgen deprivation therapy, and the heightened risk of falling persisted for more than a year after ending therapy, a study has revealed.
At the recent European Society for Medical Oncology meeting, OHSU oncologist Julie Graff, M.D., presented the first evidence of meaningful clinical activity for PD-1 blockade in men with aggressive, advanced-stage prostate cancer. It’s a heartening result given that prior studies of men with metastatic prostate cancer showed no evidence of anti-tumor activity with immune therapies that work by blocking PD-1 signals. In a video interview with ecancertv.org, Graff talked about what the findings could mean for patients.
Cancer researchers presented more than 5,200 study findings at the American Society of Clinical Oncology meeting in June. Amid the hubbub, Knight Cancer Institute Deputy Director Tom Beer, M.D., observed, “All of the progress that we see here at ASCO is largely the result of patients who are courageous enough to volunteer for clinical studies.” With three expert colleagues at the meeting in Chicago, Beer led an online discussion digging in to questions that matter for men with prostate … Read More
Losing bone and muscle mass while gaining fat is a troubling problem for men receiving androgen deprivation therapy for prostate cancer, putting them at risk for heart disease, frailty and broken bones. Depletion of bone in these men is even more rapid than that associated with menopause in women. But a first-of-its-kind randomized clinical trial is providing evidence that targeted exercise can slow bone loss, reverse muscle weakness, and prevent gains in body fat in … Read More