Posts Tagged ‘PARP inhibitor’

Outsmarting treatment-resistant prostate cancers

Aggressive prostate tumors can rapidly evolve to resist PARP inhibitors, but it may be possible to detect resistance early enough to counteract.   Two views of the structure of the DNA-repair protein PARP1 It was a surprising discovery that opened up a new avenue for treating prostate cancer. In recent years, studies have revealed that gene mutations long associated with breast and ovarian cancers – BRCA1 and BRCA2 – also play a significant role in driving … Read More

Digging in to questions that matter for men with prostate cancer

Cancer researchers presented more than 5,200 study findings at the American Society of Clinical Oncology meeting in June. Amid the hubbub, Knight Cancer Institute Deputy Director Tom Beer, M.D., observed, “All of the progress that we see here at ASCO is largely the result of patients who are courageous enough to volunteer for clinical studies.” With three expert colleagues at the meeting in Chicago, Beer led an online discussion digging in to questions that matter for men with prostate … Read More

Solving the problem of drug-resistant cancer

Solving the problem of drug-resistant cancer

To discover ways to prevent or delay drug resistance in cancer, a new NCI-funded center at OHSU is exploring how acute myeloid leukemia cells evolve and adapt.