The seeds of heart disease risk are planted before birth

Heart disease, rare only a century ago, is now the most common cause of death worldwide. Many explanations for this meteoric rise have been put forth, but most have fallen well short of explaining how this once rare chronic disease could kill the equivalent of the population of Portland, Oregon each year.

About 25 years ago an English epidemiologist named David Barker found that areas of England with high rates of infant deaths following WWII had high rates of adult death from heart disease 50 years later. His curiosity led to one of the largest paradigm shifts in medicine during the past century. Heart disease is not a result of faulty genes or how many value meals we consumed as adults.

Risk for heart disease is programmed into our makeup before we are even born based on how we grew in the womb.

How it workstoddler-with-baby-brother-850x570

Think about planting a garden – if the seeds are planted in poor soil and aren’t nourished with sunlight and water, the plants will grow poorly. They will be smaller and less healthy. The same is true for humans. A developing fetus senses its environmental surroundings and sets a growth pattern accordingly. If there are few nutritional stores available, the fetus will grow slowly and have a lower birth weight.

The heart, along with most of the body’s other organs and systems, is fully formed at birth and will only enlarge as we grow. A poor nutritional environment in the womb can lead to permanent changes in the structure of the heart, including fewer cells and poor blood flow. Since a body’s organs do not work in isolation, but in a synchronized concert we know that other effects of poor nutrition in the womb contribute to heart disease risk as well. Small babies are born with fewer kidney filtering units and therefore at risk for having high blood pressure as adults. They are also less able to process insulin and are therefore more likely to get diabetes. We also know their livers are less likely to handle cholesterol efficiently. High blood pressure, diabetes and high cholesterol are all independent risk factors for heart disease. Overall, low birth weight babies are less able to adapt to the world outside the womb and are more vulnerable for developing heart disease in adulthood.

Barker’s hypothesis was initially met with disbelief, after all it went against the messages health care providers had been promoting for decades – that heart disease resulted from poor dietary choices like too much saturated fat or too little fiber, poor lifestyle choices like smoking, or from as-yet-undiscovered genes.  How could birth weight predict death from heart disease 50 or more years later?

Multiple studies have now found the same link in differing populations, timeframes and geographic areas. What was once Barker’s hypothesis has become one of the fasted growing fields of research, now known as the Developmental Origins of Health and Disease, or DOHaD.

Smaller full-term babies, those born at five pounds or less have a three to five times higher risk of dying from heart disease then those born at eight to nine pounds. The risk can be seen across a graded scale, with babies born at five pounds having a higher risk than those born at six pounds, and those born at seven pounds having a higher risk than those born at six pounds. Risk begins to increase again in larger birth weight babies, those born at 10 pounds and above. We now know that birth weight alone is merely a rough indicator of how a baby grew in the womb. Placental size, shape and function as well as the mothers’ body type all play a role in the development of adult onset heart disease.

What it means

While we have made incredible strides in treating heart disease so that fewer people die from it, we have done a poor job at preventing heart disease. The field of developmental origins shows us that to reduce rates of heart disease, we must focus on prevention much earlier than we once thought. Waiting to discuss nutrition with fifty-year-old adults is too late. We need to focus on improving our food culture to ensure adolescents and women of childbearing age have easy access to affordable, nutritious whole foods. This will ensure our hearts are built strong and heart disease can once again become a rarity.

This article has been republished from


Thornburg picture 2012Kent Thornburg, Ph.D. is Director of the Center for Developmental Health at the Knight Cardiovascular Institute, and Director of the Bob and Charlee Moore Institute for Nutrition & Wellness. He studies the roles of the placenta and the intrauterine environment as programming agents for adult-onset chronic disease and he leads studies on maternal diet and body in regulating fetal growth in women of Oregon.

Bookmark and Share

Comments are closed.

About the Author

Why 96,000 Square Miles?

OHSU Health Fair at Pioneer Square.

President Robertson is fond of saying that OHSU has a 96,000 square mile campus, serving Oregonians “from Enterprise to Coos Bay, from Portland to Klamath Falls.”

This blog aims to highlight that breadth. 96,000 Square Miles (96K for short) will focus on the people of OHSU, the Oregonians we serve and the ripple effect of our work in Oregon and beyond.

Read more

Participation Guidelines

Remember: information you share here is public; it isn't medical advice. Need advice or treatment? Contact your healthcare provider directly. Read our Terms of Use and this disclaimer for details.