The Lutsenko Lab has 27 relevant publications.
[PDF] - *RESTRICTED*

1. Barnes, N., Tsivkovskii, R., Tsivkovskaia, N., Lutsenko, S. (2005) The copper-transporting ATPases, Menkes and Wilson disease proteins, have distinct roles in adult and developing cerebellum J. Biol. Chem. Epub:ahead of print. Pubmed    
2. Efremov, R., Kosinsky, Y.A., Nolde, D.E., Tsivkovskii, R., Arseniev, A.S., Lutsenko, S. (2004) Molecular modeling of the nucleotide-binding domain of the Wilson' disease protein: location of the ATP-binding site, domain dynamics, and potential effects of the major disease mutations. Biochem J. :Epub. Pubmed    
3. Morgan, C.T., Tsivkovskii, R., Kosinsky, Y.A., Efremov, R., Lutsenko, S. (2004) The distinct functional properties of the nucleotide-binding domain of ATP7B, the human Copper-transporting ATPase. Analysis of the wilson disease mutations E1064A, H1069Q, R1151H, and C1104F. J. Biol. Chem. :Epub. Pubmed    
4. Ralle, M., Lutsenko, S., Blackburn, N.J. (2004) Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B): X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal binding domains and their interaction with exogenous ligands J. Inorg. Biochem. 98:765-74. Pubmed    
5. Walker, J.M., Huster, D., Ralle, M., Morgan, C.T., Blackburn, N.J., Lutsenko, S. (2004) The N-terminal metal-binding site 2 of the Wilsons disease protein plays a key role in the transfer of copper from Atox1 J. Biol. Chem. 279:15376-84. Pubmed    
6. Huster, D., Lutsenko, S. (2003) The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein J. Biol. Chem. 278:32212-8. Pubmed    
7. Lutsenko, S., Tsivkovskii, R., Walker, J.M. (2003) Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1. Ann. NY Acad. Sci. 986:204-11. Pubmed    
8. Tsivkovskii, R., Purnat, T., Lutsenko, S. (2003) Copper-transporting ATPases: The key regulators of intracellular copper concentrations. Handbook of ATPases (eds. Futai, Kaplan, Wada) Wiley-VCH Verlag GmbH, Weinheim:in press.
    
9. Ralle, M., Lutsenko, S., Blackburn, N.J. (2003) X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines. J. Biol. Chem. 278:23163-70. Pubmed    
10. Tsivkovskii, R., Efremov, R., Lutsenko, S. (2003) The Role of the Invariant His1069 in Folding and Function of Wilson’s disease Protein, the Human Copper-transporting ATPase ATP7B. J. Biol. Chem. 278:13302-8. Pubmed    
11. Gerbasi, V., Lutsenko, S., Lewis, E.J. (2003) A Mutation in the ATP7B Copper Transported Causes Reduced Dopamine ß-Hydroxylase and Norepinephrine in Mouse Adrenal. Neurochem. Res. 28:867-73. Pubmed    
12. Lutsenko, S., Tsivkovskii, R., Cooper, M.J., MacArthur, B.C., Bachinger, H.P. (2002) Biochemistry of the Wilson's disease Protein. Handbook of Copper Pharmacology and Toxicology (ed. E.J. Massaro). Humana Press, Totowa, NJ:pp. 35-51.
     
13. Lutsenko, S., Efremov, R., Tsivkovskii, R., Walker, J.M. (2002) Human Copper-Transporting ATPase ATP7B (The Wilson’s Disease Protein): Biochemical Properties And Regulation. J. Biomemb. Bioenerg. 34:351-62. Pubmed    
14. Lutsenko, S., Petris, M. (2002) Function and Regulation of the Mammalian Copper-transporting ATPases: Insightes from Biochemical and Cell Biological Approaches . J. Memb. Biol. 191:1-12. Pubmed    
15. Vanderwerf, S.M., Lutsenko, S. (2002) The Wilson's disease protein expressed in Sf9 cells is phosphorylated. Biochem. Soc. Transac. 30:739-41. Pubmed    
16. Walker, J.M., Tsivkovskii, R., Lutsenko, S. (2002) Metallochaperone Atox1 Transfers Copper to the NH2-terminal Domain of the Wilson's Disease Protein and Regulates Its Catalytic Activity. J. Biol. Chem. 277:27953-9. Pubmed    
17. Tsivkovskii, R., Eisses, J.F., Kaplan, J.H., Lutsenko, S. (2002) Functional Properties of the Copper-transporting ATPase ATP7B (the Wilson’s disease protein) expressed in insect cells. J. Biol. Chem. 277:976-983. Pubmed    
18. Vanderwerf, S.M., Cooper, M.J., Stetsenko, I.V., Lutsenko, S. (2001) Copper Specifically Regulates Intracellular Phosphorylation of the Wilson's Disease Protein, a Human Copper-Transporting ATPase. J. Biol. Chem. 276:36289-94. Pubmed    
19. Tsivkovskii, R., MacArthur, B.C., Lutsenko, S. (2001) The K1010-K1325 Fragment of the Wilson’s Disease Protein Binds Nucleotides And Interacts With the N-Terminal Domain of This Protein In a Copper-Dependent Manner. J. Biol. Chem. 276:2234-42. Pubmed    
20. Noll, M.M., Lutsenko, S. (2000) Expression of ZntA, A Zinc-Transporting P1-type ATPase, Is Specifically Regulated By Zinc And Cadmium. Life 49:297-302. Pubmed    
21. Buiakova, O.I., Xu, J., Lutsenko, S., Zeitlin, S., Das, K., Das, Sh., Ross, B.M., Mekios, C., Scheinberg, I.H., Gilliam, T.C. (1999) Null mutation of the murine ATP7B (Wilsons disease) gene results in intracellular copper acucmulation and late-onset hepatic nodular transformation. Hum. Mol. Genet. 8:1665-71. Pubmed    
22. Gatto, C., Lutsenko, S., Shin, J.M., Sachs, G., Kaplan, J.H. (1999) Stabilization of the H+,K+-ATPase M5M6 hairpin by K+ ions. Mechanistic significance for P2-type ATPases. J. Biol. Chem. 274:13737-40. Pubmed    
23. Ralle, M., Cooper, M.J., Lutsenko, S., Blackburn, N.J. (1998) X-Ray Absorption Studies On The Soluble N-Terminal Domain Of The Menkes Disease Protein (N-MNK-P) With Multiple Copper Site Occupancy. Evidence For A Two-Coordinate Copper-Cysteinate Coordination Environment. J. Am. Chem. Soc. 120:13525-6. PDF reprint
     
24. Noll, M.M., Petrukhin, K., Lutsenko, S. (1998) Identification Of A Novel Transcription Regulator From Proteus Mirabilis, PMTR, Revealed The Possible Role Of The YJAI Protein In Balancing Zinc In E. Coli. J. Biol. Chem. 273:21393-401. Pubmed    
25. Lutsenko, S., Cooper, M.J. (1998) Localization of the Wilson’s disease protein product to Mitochondria. Proc. Natl. Acad. Sci. USA 95:6004-9. Pubmed    
26. Shah, A.B., Chernov, I., Zhang, H.T., Ross, B.M., Das, K., Lutsenko, S., Pavano, E., Pavone, L., Evgrafov, O., Ivanovna-Smolenska, I., Anneren, G., Westermark, K., Urritia, F.H., Penchaszadeh, G.K., Sternlieb, I., Scheinberg, I.H., Gilliam, T.C., Petrukhin, K. (1997) Identification and analysis of mutations in the Wilsons disease gene (ATP7B): Population frequencies; genotype-phenotype correlations, and functional analysis. Am. J. Hum. Genetics 61:317-28. Pubmed    
27. Lutsenko, S., Petrukhin, K., Cooper, M.J., Gilliam, T.C., Kaplan, J.H. (1997) N-terminal domains of Human Copper-transporting Adenosine Triphosphatases (the Wilson and Menkes Disease Proteins) Bind Copper Selectively in vitro and in vivo with Stoicheometry of One Copper per Metal-Binding repeat. J. Biol. Chem. 272:18939-44. Pubmed