Lab Intranet
The Program Project “Metal
Ion Regulation in Human Cells” [NIH
CRISP record] brings
together efforts of several research laboratories to understand the molecular
mechanisms of copper and iron homeostasis in human cells. Disruptions of
metal homeostasis are being increasingly invoked as the basis for a number
of neurodegenerative
and other life-threatening diseases. The goal of this project is to dissect
the mechanisms regulating metal concentration in human cells at the structural,
biochemical, and cell biological levels and to provide this important information
to biomedical community. This interdisciplinary program involves investigations
of structure and metal-ion coordination for several physiologically important
metalloproteins, understanding the molecular mechanisms of copper and iron
transport in mammalian cells, and analysis of copper-mediated signaling in
normal and
diseased human cells. In addition to collaborative investigations, the PPG
researchers participate in the “Metal and Membranes Journal Club” and
have Seminar Series dedicated to recent advances in the area of human metal
homeostasis.
The Metal Ion Core facilitates the research
of PPG investigators.
The PPG investigators are:
- Svetlana Lutsenko, Ph.D.
Associate Professor
Oregon Health & Science University, Portland, OR
"Regulatory role of Cu in human cells" - Ninian Blackburn, Ph.D.
Professor
OHSU OGI School of Science & Technology, Portland, OR
"Chaperone-target interactions" - Jack H. Kaplan, Ph.D., F.R.S.
Professor and Chair
University of Illinois, Chicago, IL
"Copper entry into human cells" - Caroline Enns, Ph.D.
Professor
Oregon Health & Science University, Portland, OR
"The role of transferrin receptor 2 in iron homeostasis" - Larry David, Ph.D.
Professor
Oregon Health & Science University, Portland, OR
"Core--Metal Ion Regulation /Transport" - Martina Ralle, Ph.D.
Research Associate
Oregon Health & Science University, Portland, OR
Metal Ion Core Facility
Designed and maintained
by Tina D. Purnat (purnatt@ohsu.edu).
Last update: July 25, 2004.
The Lutsenko Laboratory, Department
of Biochemistry and Molecular Biology, MRB 624, Mail Code L224,
Oregon Health & Science University, 3181 SW Sam Jackson Pk Rd, Portland,
OR 97239-3098
503-494-7501 (tel), 503-494-8393 (fax)
under grant number MCB-0110057. Any opinions, findings, and conclusions or recommendations
expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.