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- Metal-binding sites
-
- MBS 1 [PDB]
- MBS 2 [PDB]
- MBS 3 [PDB]
- MBS 4 [PDB]
- MBS 5 [PDB]
- MBS 6 [PDB]
- Transmembrane Segments
- TM Segment 1
- TM Segment 2
- TM Segment 3
- TM Segment 4
- TM Segment 5
- TM Segment 6
- TM Segment 7
- TM Segment 8
- ATP-Binding Domain
- ATP BD structure model
- Alignments
-
- Cu-transporters
- Phylogenetic tree [RESTRICTED]
- WNDP mutations
- Links to WNDP research
The search for the P1-type ATPases was conducted in the NCBI Genebank,
Protein databank and SwissProt database and cross-checked for the
presence of duplicate sequences.
The resulting 251 sequences were aligned with ClustalW program with
default settings, and the alignment was used to produce a phylogenetic
tree with TREEVIEW. The assignment of metal specificity to groups in the
phylogenetic tree was based on available
experimental information for individual members of each group.
(Please email Svetlana Lutsenko at lutsenko@ohsu.edu for details on
this project.)
60 Cu-transporting ATPAses that grouped
together in the phylogenetic analysis. An alignment of these sequences was
made with Clustal. The alignment is available in the HTML or PDF format.
The residues conserved >95% across the sequences are reported in the information on
the individual transmembrane segments and the ATP7B (WNDP) mutations
table.
Designed and maintained
by Tina D. Purnat (purnatt@ohsu.edu).
Last update: July 25, 2004.
The Lutsenko Laboratory, Department
of Biochemistry and Molecular Biology, MRB 624, Mail Code L224,
Oregon Health & Science University, 3181 SW Sam Jackson Pk Rd, Portland,
OR 97239-3098
503-494-7501 (tel), 503-494-8393 (fax)
under grant number MCB-0110057. Any opinions, findings, and conclusions or recommendations
expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.