gi|2622654|heavy-metal transporting ATPase
gi|2650152|pacS
gi|728935|ATU2_YEAST
gi|14132780|copper-transporting P-type ATPase
gi|24528450|CLAP1
gi|28625435|CtaA
gi|3006137|SPBC29A3
gi|416665|COPA_ENTHR
gi|12723759|copper/potassium-transporting ATPase
gi|7531047|ATCU_BACSU
gi|21401709|E1-E2_ATPase
gi|14248331|copper-transporting ATPase
gi|22776823|copper-transporting ATPase
gi|16414468|lin1967
gi|584792|ATCS_SYNP7 pacS
gi|17134720|cation-transporting ATPase
gi|2493001|ATCS_SYNY3 pacS
gi|7531049|ATCU_RHIME
gi|15140904|putative copper-transporting P-type ATPase
gi|17739598|heavy-metal transporting P-type ATPase
gi|23347000|copper-translocating P-type ATPase
gi|1353678|heavy-metal transporting P-type ATPase
gi|16026849|putative cation-transporting P-type ATPase
gi|16418854|putative cation transport ATPase
tr|Q9RRN5
gi|11351437|PA3920
gi|24981973|heavy metal translocating P-type ATPase
gi|28851214|copper-translocating P-type ATPase
gi|9965435|CopA
gi|24376802|copper-transporting ATPase
gi|22533403|CopA
gi|15026756|Heavy-metal transporting P-type ATPase
gi|3323366|cation-transporting ATPase
gi|179253|Cu++-transporting P-type ATPase
gi|1351992|AT7A_CRIGR
gi|1351993|AT7A_HUMAN
gi|451487|Cu++-transporting P-type ATPase
gi|12644462|AT7A_MOUSE
gi|12229551|AT7A_RAT
gi|631354|copper-transporting ATPase
gi|1703455|AT7B_HUMAN
gi|738766|Cu transporting ATPase P
gi|1947035|ATP7B [Homo sapiens]
gi|3121725|AT7B_RAT
gi|12643938|AT7B_SHEEP
gi|12229577|AT7B_MOUSE
tr|Q9VYT4
gi|9367132|CUA-1
gi|17556548|cua-1
gi|14972204|cation-transporting ATPase
gi|15458226|P-type ATPase
tr|P77881
gi|12229667|AHM5_ARATH
gi|15636781|copper-transporting P-type ATPase
gi|12229670|AHM7_ARATH
tr|Q9WYF3
gi|13815964|pacS
gi|15622807|hypothetical cation-transporter ATPase
gi|18161111|cation-transporting ATPase
tr|Q9YBZ6
Clustal Consensus
|
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---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -----MKRIT
IRIGGMGCAA CALKIEEALR KLDGIRDAAV NLVEGKVSVE YDPRRVDLSD MEAAIEDAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- TVLNENIAMA
VGGMSCAMCV QKIES----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALR GLEGVSNATV NLAA------ ---------- ----------
---EKAYISY NPS------- ---------- ---------- ---------- ---------- ----------
-LTSVEDLKR TVEDLG---- YTVRGLEGEE --ISEDLKP- ---------- ---------- --------KI
RRIIVGFGVS VPLMAMMYLG LQPPGG---- ---------- ---------- ---------- -GISMLLVSI
IPFIYVSGPI FRG--ALRSL R-----SGTL DMDVMYSMGI GVAFLSSILG TAGILPS--- ----------
DFMFYDTALM LASFLTLGRY LEAGARGKTS EAVRRLMELQ PDTATVLRDG R--------- ----------
---------- EVEVRIHEID VGDEVIVRPG DRVPADGKVV EGSSYVDEFM ITGEPLPALK TPGSEVVAGT
INTDGILRFR VERTGDETFL SGIIKLVDEA QASKPPIQRI ADRAVSYFIP AVLLVATSAF LFWYLVEG--
---------- ---------A GLLLSITVLI SVLVVACPCA LGLATPTAVT AGIGRGAELG ILIKKGEALE
VSDRISCVIF DKTGTLTLGR PRVTDMVG-- ---------- ---------- ---------D VLGLAAALER
---------- KSRHPIAAAV TERAEEE--- ---------- ---------- ---GVDVPEA EDFRAIPGMG
LEGMVDSHH- ---------- ---------- ---------- ---------- ---------- -VLAGNRALM
EKYG------ ----IPLE-- -HWDPEKFES DGKTVVIVAV DGEVKG---- -IIAVSDEIK PGSARAVREL
ERMGIGTAMI TGDNRKTAEA VAREVGIG-- TVIAEVLPQD KATRVAELRE RG-------E GVAFVGDGIN
DAPALAEADL GVAVGSGTDI AREAGEVVLM GD------DP LDVPAALQLA GKVISRIRQN IFWAFAYNVV
LIPLAAGALY P-LGIVFRPE YAGLAMALSS VTVVSLSLTL RGYTPPARR- ---------- ----------
---------- --------LR EKQGEG---- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---MVKDTYI SSASKTPPME RTVR------ ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
VTGMTCAMCV KSIET----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------AVG SLEGVEEVRV NLAT------ ---------- ----------
---ETAFIRF DEK------- ---------- ---------- ---------- ---------- ----------
-RIDFETIKR VIEDLG---- YGVVDEQAAV SAEVEHLSR- ---------- ---------- --------MK
RKLYVAAFAG VLLLFLAHF- ISLPYE---- ---------- ---------- ---------- -DFVQLLIAL
PAIFYSGSSI FKA--AFSAL R-----RRTL NMDVMYSMGV GAAFLASVLS TAGVLPR--- ----------
EYSFYETSVL LLAFLLLGRT LEARAKSRTG EAIKKLVGLQ AKTAVVIRDG K--------- ----------
---------- EIAVPVEEVA VGDIVIVRPG EKIPVDGVVV EGESYVDESM ISGEPVPVLK SKGDEVFGAT
INNTGVLKIR ATRVGGETLL AQIVKLVEDA MGSKPPIQRL ADKVVAYFIP TVLLVAISAF IYWYFIAH--
---------- ---------A PLLFAFTTLI AVLVVACPCA FGLATPTALT VGMGKGAELG ILIKNADALE
VAEKVTAVIF DKTGTLTKGK PEVTDLVPLN GDER------ ---------- ---------E LLRLAAIAER
---------- RSEHPIAEAI VKKALEH--- ---------- ---------- ---GIELGEP EKVEVIAGEG
----VVADG- ---------- ---------- ---------- ---------- ---------- -ILVGNKRLM
EDFG------ ----VAVSNE VELALEKLER EAKTAVIVAR NGRVEG---- -IIAVSDTLK ESAKPAVQEL
KRMGIKVGMI TGDNWRSAEA ISRELNLD-- LVIAEVLPHQ KSEEVKKLQA K--------E VVAFVGDGIN
DAPALAQADL GIAVGSGSDV AVESGDIVLI RD------DL RDVVAAIQLS RKTMSKIKQN IFWALIYNVI
LIPAAAGLLY PIFGVVFRPE FAGLAMAMSS VSVVANSLLL RNYVPPIRRG GDSVEKIVLE LSGLSCHHCV
ARVKKALEEA GAKVEKVDLN EAVVAGNKED VDKYIKAVEA AGYQAKLRS- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- --MREVILAV HGMTCSACTN TINTQLRALK
GVTKCDISLV TNECQVTYDN EVTADSIKEI IEDCG----- -FDCEILRDS EITAISTKEG ---------L
LSVQGMTCGS CVSTVTKQVE GIEGVESVVV SLVTEECHVI YEPSKTTLET AREMIEDCG- ---FDSNIIM
DGNG------ ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- --------NA DMTEKTVILK
VT-------- KAFED----- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---ESPLILS SVSERFQFLL DLG------- -----VKSIE ISDD------
--MHTLTIKY CCN------- ---------- ---------- ---------- ---------- ----------
-ELGIRDLLR HLERTG--YK FTVFSNLDN- -TTQLRLLSK E--------- ---------- ---DEIRFWK
KNSIKSTLLA IICMLLYMIV PMMWPTIV-- ---------- --QDRIFPYK ETSFVRGLFY RDILGVILAS
YIQFSVGFYF YK--AAWASL K-----HGSG TMDTLVCVST TCAYTFSVFS LVHNMFHPSS TGK------L
PRIVFDTSIM IISYISIGKY LETLAKSQTS TALSKLIQLT PSVCSIISDV E--------- ------RNE-
---------- TKEIPIELLQ VNDIVEIKPG MKIPADGIIT RGESEIDESL MTGESILVPK KTGFPVIAGS
VNGPGHFYFR TTTVGEETKL ANIIKVMKEA QLSKAPIQGY ADYLASIFVP GILILAVLTF FIWCFILN-I
SANPPVAFTA NTK-----AD NFFICLQTAT SVVIVACPCA LGLATPTAIM VGTGVGAQNG VLIKGGEVLE
KFNSITTFVF DKTGTLTTGF MVVKKFLKDS NWVGNVDED- ---------- ---------E VLACIKATES
---------- ISDHPVSKAI IRYCDG-LNC N--------- ---------- ---KALNAVV LESEYVLGKG
IVSKCQ---- ---------- ---------- ---------- ---------- -VNGN---TY DICIGNEALI
LED------- ------ALKK SGFINSNVDQ -GNTVSYVSV NGHVFG---- -LFEINDEVK HDSYATVQYL
QRNGYETYMI TGDNNSAAKR VAREVGISFE NVYSDVSPTG KCDLVKKIQD KEGNNK---- -VAVVGDGIN
DAPALALSDL GIAISTGTEI AIEAADIVIL CGNDLNTNSL RGLANAIDIS LKTFKRIKLN LFWALCYNIF
MIPIAMGVLI PWG-ITLPPM LAGLAMAFSS VSVVLSSLML KKWTPPDIES HG-------- ----------
--------IS DF-----KSK FSIGNFWSRL FSTR----AI AGEQDIESQA GLMSNEEVL- ----------
-----------
---------- ---------- ---MKSSAIL ESNPNQNNNV TVVLEVLDLH TAKDITDVIN ILDELFPKLK
SKDFDHQELT LIYDSNDYDD MSILNAISEI GFPVKILSST APQCKTTVNI QGMTCGACSA SITEALEKTP
GVYKASISLV TENGLIMHSP KLSPENIITI IEDCG----- -FDAQIESSK TKQSSAPESS QDQSKRLNTT
IGIIGMTCGA CSASITNVLE KLPGVENVSV SLITEEASIV HDSTITTVQQ LKEAIEDCGF TPTFNKSINL
NQYQ------ ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- --------NT NDSNEEVTLK
IVGVNHTTDL IGLRY----- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---NIEAYLR SISGVQKFEL TLRGMNASSN IMPTQVGTLI TEEDTIADVK
SLVNELVFQY DSD------- ---------- ---------- ---------- ---------- ----------
-SVGIRDIID GLNTISDNIE FMVINSLDQS SATQLKLLSK V--------- ---------- ---KDINYWK
KIFIQSLLFG IPVLFLNHTK --NWPIWK-- ---------- --TTMIFP-- ------GLYL VSLLELILST
YIQFYLGSVF IKKFSSFLRK K-----FKGA TMDVLVCIST MCSYIFSLTT IIVSVWNGQK NGP------P
P-VLFDTLVM LISFVSFGKL LENKAKGATS TALSSLLSLT PSTCTIINDI PGYQKFIE-- DQQSLEKSEK
SNSLSMQEFP TRVISIDLVQ PNDIAIVLPG GKVPADGEIV FGETEIDESL ITGEPLPVYK KLKDKVIGGS
INGPHLIHIK VTHTGKKSQL QQIINLVKES QVNKAPVQKF SDYIAARFVP FVLLLAIFTF ILWMIICFTI
HQDKLPKIFQ NET-----NG KFFVCLKLSI SVIVVACPCA LGLAAPTAVM VGTGVGAING VLIKGAKVLE
KITGVNIILF DKTGTLTTGE MSLVNFQPIM SKS-SITIS- ---------- ---------D WWKLVGSVEC
---------- HSEHPIGRAL TKSAKTNLNL NF-------- ---------- -DDDHFDTTV NDINVLIGLG
IQANVT---- ---------- ---------- ---------- ---------- -LANNPQTQF NVYVGNDKLI
ESK------- ------FPNL LNNIDEKLLH SANTVSHVII DGEYSG---- -YIELTDALK SGSWEVVNYL
KTQGYIVGMV TGDNRGAALK IAQEVGIPFD NVFYEVSPIH KDNVITDLHN RLGGNQSSSV NVAFIGDGIN
DAPALAKADI GMAISSGTDI AIESADIVLI GG-RSNQTDL HGVVNALQIS TATFNRIKIN FLWAIIYNIF
MLPFAMGCFL PLN-IVLPPV AAGAAMMFSS LSVVFSSLLL KRWTPPKIET KKTFIDDLEM GNNATGGDGD
GFSLKNGTIE EFNNVKRKSA VNFSSLFAKM TTTRRNRRGG GGGGGRSNGN NNQSYELVSN RFS-------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- -----MAPPN IKVPPPNDGS RKTLLATPTA THMATTTLKV GGMTCGACTS AVESGFKGVE
GVGSVSVSLV MERAVIMHNP EHISADQIAE IIEDRGFDAE VLSTDLPSPM FPTEQNLFDA EDVSGLLTTT
IAVEGMTCGA CTSAVEGGFK DVPGVKNFSI SLLSERAVIE HDPDLLTAEQ IAEIIEDRG- ---FGAEIVD
SGSAQQEKPR ASS------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- --------NP ISTVATTTIA
VEGMTCGACT AAVEGGFKEI DGVLRFNISL LAERAVITHD TAVLSAEKIA EIIEDRGFGA EILSTASETS
PHGGSASTAQ FKIYGNPDAT QALALEAKLS SLAGINSAKL SLAT------ ---------- ----------
---SRLTITH QPN------- ---------- ---------- ---------- ---------- ----------
-IIGLRGIVE AVEAEG---- LNALVSDNDD NNAQLESLAK T--------- ---------- ---REINEWR
KAFKLSLSFA IPVFFISMVL PMCFSAID-- ---------- --FGSLQILP ------GIFL GDLICLALTI
PVQFGIGKRF YI--SGWKSI K-----HGSP TMDVLVILGT SCAFFFSIIA MLVSFFF-PP HS-------R
PTTLFDTSTM LITFVTLGRF LENRAKGQTS KALSRLMSLA PSMATIYADP IAAEKAAEGW ENASVSGEPK
TPNRDGHAAE EKVIPTELLQ VGDVVILRPG DKIPADGILV RGETYVDESM VTGEAMPVQK KKGSYFIGGT
VNGHGRVDFR VSRAGRDTQL SQIVKLVQDA QTTRAPIQRL ADTLAGYFVP AILMLGFLTF VVWMVLSHAL
TN--PPKIFT QEAS----GG KIMVCVKLCI SVIVFACPCA LGLATPTAVM VGTGIGAENG ILVKGGAALE
TTTRITQIVL DKTGTITYGK MSVAKMNLLP AWQDSEWR-- ---------- -------RRL WWHTVGLAEM
---------- GSEHPVGRAV LRAAKAELGL D--------- ---------- -EEATLEGSV GEFKAAVGRG
INALVEP--- ---------- ---------- ---------- ---------- -AVSSKRTRY RVLLGNVRFL
RENNVDVPVE AVEASEQLNV MANNSAKNTS AGTTNIFVAI DGAYTG---- -HLCLSDTIK EGAAAAIAVL
HRMKIKTAIV TGDQRSTAVA VAAAVGISSD NVFAGVSPDQ KQAIVQQLQD Q-------GE VVGMVGDGIN
DSPALATADV GIAMASGTDV AMEAADVVLM RP-----TDL MDIPAALHLA RSIFNRIKLN LAWACLYNAI
GLPFAMGVFL PFG-FHLHPM AAGAAMACSS VSVVASSLLL KFWTRP--SY MTD------- ----------
---------- ----PSTQTK RRGFGIANRV KHVIRRVS-- -GRRTQDQGY VPLANMADRD ED--------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- --------MA GLSAAFNGLL
GTPRTPTSGK LELPVGEHEP LAAAGGPASE KCELR----- ---------- ---------- ----------
--IEGMTCGA CVESIEGMLR TQPGIQSVKV ALLAERGVVE YDPAVWDADK IIGEISDIG- ---FDATLIP
P--------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -TRADAITLR
IYGMTCSSCT STVET----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------QLG AMPGVTSVAV SLAT------ ---------- ----------
---ETCKVEF DRT------- ---------- ---------- ---------- ---------- ----------
-MVGPRELVE RIEEMG---- FDAMVSDQED -ATQLRSLTR T--------- ---------- ---KEIQEWR
SRFQWSLAFA IPVFFVTMIA PKIPFLAP-- ---------- --IVEYQLCR ------GIYV SDVVAFILTT
PALFWLGQKF YR--NAYKSL K-----HGSA TMDVLIAIGT SSAYIYSIGA MCFAAYN-RE LDY------H
PMVFFDTSTM LIMFVSLGRY LENRAKGKTS AALTDLMALA PSMATIYTDA PACT------ ----------
---------Q EKKIPTELVS VGDTVKLVPG DKVPADGTVL RGTSTVDESA VTGEPVPVLK QIGDSVIGGT
VNGLGTFDMV VTRAGKDTAL AQIVKLVEDA QTSKAPIQEF ADKVAGYFVP MVISLSLITF AVWMVISHVV
DENALPALFH KHG-----AS KLAICLQLCI SVVVVACPCA LGLSTPTAIM VGTGMGAKNG ILIKGGRALE
ASRFIKRIAL DKTGTVTEGK LTVAALTWAP SSDHSDLHSY ATDGDVPLTT KCVGNATRAD VIAMVAATEA
---------- RSEHPLAKAV AVHGKELLNK S--------- ---------- -MVPIPEVVI HTFESVTGAG
VKAEIG---- ---------- ---------- ---------- ---------- --LPGGKGQC TLFVGNARFI
LQT------- --GDAQLPSA LAAFDSEESH RGRTSIFVSI STSGKPPVPI LAIALADAPR PSSIHAIRAL
QNMGIEVNML TGDAKATALA VAKQVGIKPE NVWASMSPKG KASVVTELME KY------GG GVAMVGDGIN
DSPSLVAASV GIALSSGTSV AIEAADIVLM R------SDL LDVVAALHLS RAIFTTIRRN LVWACLYNVL
GIPLAMGFFL PLG-VSLPPM GAAAAMAFSS VSVVTSSLAL KWWVRPAESL MPG------- ----------
---------- ----ESVQHE TMFDSAREAV RDAWESVRGL VGSRRDVSGY SQLPVEMSEA V---------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-MYTTTLS-- ---------- ---------- ---------- ---------- ---------- ----------
--VQGMTCTS CVASIQSMLE GVEGIEQFTI SLLLERAIAV HDPSIISPDQ IAEKIEDCG- ---FDASVIS
STEG------ ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- EHGVMANYLL
LSPMQAEQWT KVHNH----- ---------- ---------- ---------- ---------- ----------
---------- ---------- --------IN ELQGVLSVNC SSSPD----- ---------- ----------
---AAIRVIY DSE------- ---------- ---------- ---------- ---------- ----------
-ITGPRSIMK EILSMG---- VKCTFQPVDS STSRILSLQR G--------- ---------- ---SQIRVWK
IRFIISISFS LAVMFLPQIF DSCDSMRA-- ---------- --AFLVPHYF ------GICA GHIISLVLSL
PVQFGVGRVY YS--AAYHAL K-----RGTA NMDVLVSLGS TVAFAASIFF MILYSAR-HA DN-------P
APIFFDTADM LLTFVTLGRY LESKAKGSTS AALSQLLSLA PSSATIIEDN ---------- ----------
---------E QIEILADLIE RGDLILVKPG EIIPVDGTVV EGSSYVDESS VSGEPVPVHK TIDDELLSGT
ANGNGRLLVK ATKSPRESQL AVIVDLVQRA QISHAPIQQF ADRVAGIFVP VIVALSISTF TFWFLFTKYS
SK--YPSVFD DPM------G KFAVCLKLTI SVVVVACPCA LGLSTPTAVM VGTGVGALNG IIIKGGEILE
RLNQVDTVVF DKTGTLTVGK LSVTDISIVD NLEELLDIP- ---------- -------KNI FWAFVKASES
---------- SSEHPIGKAI TEKASEFT-- ---------- ---------- ---DVSEIGI ESFNAVPGEG
VDVVLR---- ---------- ---------- ---------- ---------- ----WKERTF HALLGNSLLL
EHN------- ---NVSIPDD FDSKLKLSSS SGLTCVRIAI DGQFVG---- -FLGCMDQVR PDSYQTVSAL
KQLGKKVCLL TGDQKATARR VAQGLEIDFS DVYAEAVPSQ KAEIIQKLKD Q-------KH CVAMVGDGIN
DSPSLVLADV GIAPINGSGI ALESADVILV RK-----GVL LDTAVSFDLS RVIVKRIKMN LVWACIYNFV
MIPIAMGFFL PWG-IYLNPM WASAAMMFSS LSVLASSLLL RRWKKP-KSL IFS------- ----------
---------- ----EADDVE TESSTNSSVL QKVYTATRSI FGRNKSSNKY QPVANEV--- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------M ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ATNTKMETFV
ITGMTCANCS ARIEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ELN EQPGVMSATV NLAT------ ---------- ----------
---EKASVKY T-D------- ---------- ---------- ---------- ---------- ----------
-TTTER-LIK SVENIG---- YGAILYDEAH KQKIAEEKQ- ---------- ---------- ---TYLRKMK
FDLIFSAILT LPLMLAMIAM MLGSHG---- ---------- ----PIVSFF H--------- LSLVQLLFAL
PVQFYVGWRF YKG--AYHAL K-----TKAP NMDVLVAIGT SAAFALSIYN GFFPSHSH-- ----------
-DLYFESSSM IITLILLGKY LEHTAKSKTG DAIKQMMSLQ TKTAQVLRDG K--------- ----------
---------- EETIAIDEVM IDDILVIRPG EQVPTDGRII AGTSALDESM LTGESVPVEK KEKDMVFGGT
INTNGLIQIQ VSQIGKDTVL AQIIQMVEDA QGSKAPIQQI ADKISGIFVP IVLFLALVTL LVTGWLT---
---------- ---------K DWQLALLHSV SVLVIACPCA LGLATPTAIM VGTGVGAHNG ILIKGGEALE
GAAHLNSIIL DKTGTITQGR PEVTDVIG-- PKE------- ---------- ---------- IISLFYSLEH
---------- ASEHPLGKAI VAYGAKV--- ---------- ---------- -GAKTQPIT- -DFVAHPGAG
ISGTING--- ---------- ---------- ---------- ---------- ---------V HYFAGTRKRL
AEM------- ---NLSF-DE FQEQALELEQ AGKTVMFLAN EEQVLG---- -MIAVADQIK EDAKQAIEQL
QQKGVDVFMV TGDNQRAAQA IGKQVGIDSD HIFAEVLPEE KANYVEKLQK AG-------K KVGMVGDGIN
DAPALRLADV GIAMGSGTDI AMETADVTLM NS------HL TSINQMISLS AATLKKIKQN LFWAFIYNTI
GIPFAAFG-- -----FLNPI IAGGAMAFSS ISVLLNSLSL NRKTIK---- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ---MRSQSFV
ITGMTCANCV NTVSK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------TLN QSDKIMEATV NLAT------ ---------- ----------
---EKAKIVA D-D------- ---------- ---------- ---------- ---------- ----------
-NISDQEIIN LVEKAG---- YGAIVNDKAH QEKIARQAA- ---------- ---------- ---KKARNLA
LSFWIALILT LPLVVAMFAD IFGVHA---- ---------- ----NWVMFL H--------- EPIVQLILAT
PVQFVIGWRF YVG--AYHAL R-----NKSA NMDVLVALGT SVAYFSSLIL AVFMSQAN-- ----------
-ALNFESSMV IITLVVMGKL LEHNAKEKTT QAITGLMSSR AN----FVHT E--------- ----------
---------- STDLAIEEVQ MGQVIRILPG EKVPLDAMIL SGKASFDESI LTGEALPVVK MDDEVIFEGT
INLDGEVKAV VVHDLNDSTI SRMVKMMSEA QGSKPNIQKL ADKISGIFVP VVLVIALITF IATWAVS---
---------- ---------G ILLTAIMHSV AVLVIACPCA LGLATPTAII SGTGLAAKNG LLIKNANALE
LAGLVKTVFF DKTGTITTGE FELTDFKL-- LTESE---K- ---------- ---------- VTDSFNSIEE
KLASDKFKLL ASLEAHSNHP LAKSLKF--- ---------- ---------- -QGDLYELT- -DLSELAGRG
LSAKING--- ---------- ---------- ---------- ---------- ---------Q EYFAGNDKLM
TDL------- ---NLSV-PE TDD------- ---TVIYLAN KEKLLA---- -MAVFSSSLK DDALKTIQTL
QKRGLKTVML TGDNQNSAEK IQKLVHLD-- EVKSGLRPEE KAEIVQNSPN S--------- --MMVGDGIN
DAIALASATV GLAMATGSDI AMEAGDVTVT SG------QL HKISTFFEVA KKTISKIKQN YFWAFVYNVI
GIPLAAFG-- -----LLNPM LAAAAMSLSS VSVILNSLLL TKTKIKNVE- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -MLSEQKEIA
MQVSGMTCAA CAARIEKGLK RMPGVTDANV NLATETSNVI YDPAETGTAA IQEKIEKLGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- HVVTEKAEFD
IEGMTCAACA NRIEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------RLN KIEGVANAPV NFAL------ ---------- ----------
---ETVTVEY NPK------- ---------- ---------- ---------- ---------- ----------
-EASVSDLKE AVDKLG---- YKLKLKG-EQ DSEAA-AKK- ---------- ---------- ---KEERKQT
ARLIFSAVLS FPLLWAMVSH FTFTSF---- ---------- ----IWVPDI F--------L NPWMQFALAT
PVQFLIGWPF YVG--AYKAL R-----NKSA NMDVLVALGT TAAYAYSLYL TFQSIGSHGH ---------T
DGLYYETSAI LLTLILLGKL FETKAKGRSS DAIKKLMKLQ AKTATVVRDG Q--------- ----------
---------- EQIIPIDEVL VNDIVYVKPG ERIPVDGEVV EGRSAVDESM ITGESLPVDK NPGDSVTGST
VNANGFLKIK AVNVGKDTAL SHIIKIVEEA QGSKAPIQRL ADQISGIFVP IVLGIAVLTF LIWYLWAA--
---------- --------PG DFAEAISKFI AVLVIACPCA LGLATPTSIM AGSGRAAEFG ILFKGGEHLE
KTHRLDTIVL DKTGTVTNGK PRLTDAIPFG RFEEK---D- ---------- ---------- LLQFAAAAET
---------- GSEHPLGEAI IAGVKDK--- ---------- ---------- -GLEIPKLT- -RFEAKVGAG
ILAEAGG--- ---------- ---------- ---------- ---------- ---------K SILVGTRKLM
ESE------- ---QVEH-GA LLAQMEELEA EGKTVMLVSI DGEAAG---- -LVAVADTIK DTSRKAVARL
KELGLDVIMM TGDNRRTAEA IAKEAGIA-- NIIAEVLPEQ KAAEIARLQK EG-------R QTAMVGDGIN
DAPALATADI GMAIGTGTDI AMETADITLI RG------DL NSIADAIRMS RLTMKNIKQN LFWALGYNSL
GIPIAALG-- -----FLAPW IAGAAMAFSS VSVVLNALRL QKVK------ ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- --MNEQKEAN
LQISGMTCAA CANRIEKGLK KVEGVHDANV NFALEKTKIM YDPQKTNPQQ FKEKVESLGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- GIVSDKAEFT
VSGMTCAACA NRVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------RLN KLEGVNGATV NFAL------ ---------- ----------
---ESATVDF NPD------- ---------- ---------- ---------- ---------- ----------
-EINVNEMKS AITKLG---- YKLEVKSDEQ DESTD-HRL- ---------- ---------- ---QEIERQK
KKFIISFILS FPLLWAMVSH FSFTSF---- ---------- ----IYLPDM L--------M NPWVQLALAT
PVQFIIGGQF YVG--AYKAL R-----NKSA NMDVLVALGT SAAYFYSVYL SIQSIGSSEH ---------M
TDLYFETSAV LITLIILDKL FEAKAKGRSS EAIKKLMGLQ AKTATVMRDG T--------- ----------
---------- EMKILIEEVV AGDIVYVKPG EKIPVDGEIV EGKSAIDESM LTGESIPVDK TIGDVVIGST
MNKNGFLKVK ATKVGRDTAL AQIIKVVEEA QGSKAPIQRV ADQISGIFVP VVVVIAIITF AVWMIFVT--
---------- --------PG DFGGALEKMI AVLVIACPCA LGLATPTSIM AGSGRSAEYG ILFKGGEHLE
ATHRLDTVIL DKTGTVTNGK PVLTDVIVAD GFNEE---E- ---------- ---------- ILRLVGAAEK
---------- KSEHPLAEAI VEGIKEK--- ---------- ---------- -KIDIPSSE- -TFEAIPGFG
IESVVEG--- ---------- ---------- ---------- ---------- ---------K QLLIGTRRLM
KKF------- ---NIDI-EE VSKSMEELER EGKTAMLIAI NKEYAG---- -IVAVADTVK DTSKAAITRL
KKMGLDVVMI TGDNTQTAQA IAGQVGIE-- HVIAEVLPEG KAEEVKKLQA QG-------K KVAMVGDGIN
DAPALATADI GMAIGTGTDV AMEAADITLI RG------DL NSIADAIFMS KMTIRNIKQN LFWALAYNGL
GIPIAAFG-- -----FLAPW VAGAAMAFSS VSVVLNALRL QRVKLK---- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- --MANTKKTT
LDITGMTCAA CSNRIEKKLN KLDDVN-AQV NLTTEKATVE YNPDQHDVQE FINTIQHLGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- GVTVETVELD
ITGMTCAACS SRIEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------VLN KMNGVQNATV NLTT------ ---------- ----------
---EQAKVDY YPE------- ---------- ---------- ---------- ---------- ----------
-ETDADKLVT RIQKLG---- YDASIKD-NN KDQTS-RKA- ---------- ---------- ---EALQHKL
IKLIISAVLS LPLLMLMFVH LFN------- ---------- ----MHIPAL F--------T NPWFQFILAT
PVQFIIGWQF YVG--AYKNL R-----NGGA NMDVLVAVGT SAAYFYSIYE MVRWLNGSTT ---------Q
PHLYFETSAV LLTLILFGKY LEARAKSQTT NALGELLSLQ AKEARILKDG N--------- ----------
---------- EVMIPLNEVH VGDTLIVKPG EKIPVDGKII KGMTAIDESM LTGESIPVEK NVDDTVIGST
MNKNGTITMT ATKVGGDTAL ANIIKVVEEA QSSKAPIQRL ADIISGYFVP IVVGIALLIF IVWITLVT--
---------- --------PG TFEPALVASI SVLVIACPCA LGLATPTSIM VGTGRAAENG ILFKGGEFVE
RTHQIDTIVL DKTGTITNGR PVVTDYH--- --GDN---Q- ---------- ---------- TLQLLATAEK
---------- DSEHPLAEAI VNYAKEK--- ---------- ---------- -QLTLTETT- -TFKAVPGHG
IEATIDH--- ---------- ---------- ---------- ---------- ---------H HILVGNRKLM
ADN------- ---DISLPKH ISDDLTHYER DGKTAMLIAV NYSLTG---- -IIAVADTVK DHAKDAIKQL
HDMGIEVAML TGDNKNTAQA IAKQVGID-- TVIADILPEE KAAQIAKLQQ QG-------K KVAMVGDGVN
DAPALVKADI GIAIGTGTEV AIEAADITIL GG------DL MLIPKAIYAS KATIRNIRQN LFWAFGYNIA
GIPIAALG-- -----LLAPW VAGAAMALSS VSVVTNALRL KKMRLEPRRK DA-------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- --MAN-KQST
YHITGMTCAA CSNRIEKVLN RMDGVE-ANV NLTTEKASIR YDDSKFTNDD LTKKIEKIGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- GIQIEKVDLD
ISGMTCAACS NRIEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------VLN KMDGVKDATV NLTT------ ---------- ----------
---ETGSIYY YPD------- ---------- ---------- ---------- ---------- ----------
-LILESDLLN KIKKIG---- YEATPRS-EN KENIK-QKQ- ---------- ---------- ---IARTKR-
-KLIISAVLS FPLLLTMLVH LFN------- ---------- ----FEIPAF L--------M NPWFQLVVAT
PIQFWVGWQF YVG--AFKNL R-----NKTA NMDVLVAVGT SAAYFYSLYE GLLTINNSAY ---------H
PHLYYETSAI IITLVLFGKY LEARAKGQTT TAITKLLNLQ AKEARVLRKG T--------- ----------
---------- ELLIPLEEVV VGDRLIVKPG EKIPVDGIVK QGRTSVDESM ITGESIPVEK NLDSEVIGST
INKNGSIEME ASRVGTETAL SSIVKAVEDA QGSKAPIQRL ADVISGYFVP VIVMIAILTF FVWFLFVQ--
---------- --------PN QVEPALVASI AVLVIACPCA LGLATPTSIM VGTGRAAESG ILFKGGEHIE
QAYKIQSVVF DKTGTITNGK PVVTDFN--- --GDD---E- ---------- ---------- TLLLLASAEK
---------- GSEHPLAEAI TQHAEEK--- ---------- ---------- -QLDLLSTT- -DFEAIPGRG
ITAKIDN--- ---------- ---------- ---------- ---------- ---------K HIIVGNRQLM
KEY------- ---KVDSRKE E-EHLLELEN EGKTAMLIAI DGKIRG---- -TVAVADTIK ENAKEAINQL
KDMNIQVVML TGDNERTAKA IGRLAGID-- HIIAEVLPEE KAENIKALQK DG-------T AVAMVGDGIN
DAPALAVADI GIAIGTGTEI AIEAADITIL GG------DL LLVSKAIKIS QATIKNIKQN LFWAFGYNTA
GVPIAAIG-- -----LLAPW IAGAAMALSS VSVVTNSLRL KKLKV----- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------M ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- NDKYVRQDLN
VFGMTCAACS TRIEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------SLN KAEGVEKANV NLVT------ ---------- ----------
---ENAAVYY DPE------- ---------- ---------- ---------- ---------- ----------
-VTTTEELIK VVKHAG---- YDAAEKM-SK EEKDA-VLE- ---------- ---------- ---KNFKKEV
RRFILSAVLS LPLLLTMVTH IPYIHE---- ---------- ----MAFAET IG-----NWI NPTIQLVLAT
IVQFYIGWRF YDG--AYKAL R-----GKSA NMDVLVALGT SAAYFYSVVE YIRHMIDPSV ---------M
PHYYFETSAV LITLILLGKL LESYATSRTT ESIAGLLELQ AKEATVIREG K--------- ----------
---------- EWLVPVDSLK IGDIILVRPG EKVPMDAEII SGETSIDEAM ITGEPVPVEK KPGDSVIGAT
INFDGAFQAK ITKRMEETVL ESIIRLVEEA QGIKAPIQRL ADKISGIFVP IVLGIAAVTF IIWYLVT---
---------- ---------G TVDGSLEAAI AVLVIACPCA LGLATPTAIM AGTGKGAESG ILFKGGEHLE
RTSKVDTIVF DKTGTLTEGK LEVSDKK--- -ASND---K- ---------- ---------- FFPYLFLMEQ
---------- QSEHPIAKAI INMLESE--- ---------- ---------- -KIDVSDVKQ GKIRAKAGHG
MTGNLDD--- ---------- ---------- ---------- ---------- ---------S KVELGAYRYV
SS-------- ---LTTIPSE EDELIQSWMN AGKTVVAMAI DGTYAG---- -ALALSDTPR PEAKEAIQKL
QAQGIKTAIC SGDQSVVVEN MAKDLGAD-- MFFAEQLPND KSALVEKLQQ EG-------H IVAFVGDGIN
DAPALAASDI GISIGTGTDI AIETGDVTLV SH------RL TLIPETIELS KATMRNIRQN FFWALAYNCA
GIPVAALG-- -----LLAPW VAGLAMAFSS VSVVTNALRL KRYKFKS--- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----MVNQQT
LTLRGMGCAA CAGRIEALIQ ALP------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---GVQECSV NFGA------ ---------- ----------
---EQAQVCY DPA------- ---------- ---------- ---------- ---------- ----------
-LTQVAAIQA AIEAAG---- YHAFPLQDP- -WDNEVEAQ- ---------- ---------- ---ERHRRAR
SQRQLAQRVW VSGLIASLLV IGSLPM---- ---------- ----MLGISI PGIPMWLHHP --GLQLGLTL
PV-LWAGRSF FIN--AWKAF R-----QNTA TMDTLVAVGT GAAFLYSLAV TLFPQWLTRQ G-------LP
PDVYYEAIAV IIALLLLGRS LEERAKGQTS AAIRQLIGLQ AKTARVLRQG Q--------- ----------
---------- ELTLPITEVQ VEDWVRVRPG EKVPVDGEVI DGRSTVDESM VTGESLPVQK QVGDEVIGAT
LNKTGSLTIR ATRVGRETFL AQIVQLVQQA QASKAPIQRL ADQVTGWFVP AVIAIAILTF LLWFNWIG--
---------- ---------- NVTLALITAV GVMIIACPCA LGLATPTSIM VGTGKGAEYG ILIKSAESLE
LAQTIQTVIL DKTGTLTQGQ PSVTDFLAIG --DRDQQQT- ---------- ---------- LLGWAASLEN
---------- YSEHPLAEAI VRYGEAQ--- ---------- ---------- -GITLSTVT- -DFEAIPGSG VQGQVEG---
---------- ---------- ---------- ---------- ---------I WLQIGTQRWL GEL-------
-GIETSALQN QWEDWEAAGK TV---VGVAA DGHLQA---- -ILSIADQLK PSSVAVVRSL QRLGLQVVML
TGDNRRTADA IAQAVGIT-- QVLAEVRPDQ KAAQVAQLQS RG-------Q VVAMVGDGIN DAPALAQADV
GIAIGTGTDV AIAASDITLI SG------DL QGIVTAIQLS RATMTNIRQN LFFAFIYNVA GIPIAAGILY
PLLGWLLSPM LAGAAMAFSS VSVVTNALRL RQFQPR---- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -----MENTT
LKLRGMSCAS CASSIEDAIN SVP------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---GVNECIV NFGA------ ---------- ----------
---EQATIEY DPR------- ---------- ---------- ---------- ---------- ----------
-RTDLEAIQE AVDAAG---- YSAYPLQKQN LMAGDDDAE- ---------- ---------- ---KRHR-LR
ESRDLMRKVA VGGIISTVLV IGSLPM---- ---------- ----MTGLHL PFIPVWLHNP --WVQLILTT
PVQFWCGYSF YIN--GWKAL K-----RHAA TMDTLIALGT SAAYFYSLFP TLFPSFFINQ G-------LT
PDVYYETAAV VITLILLGRL FENRAKGQTS EAIRKLIGLQ AKTARLIRNG R--------- ----------
---------- EVDVPIEEVQ IGDVILVRPG EKIPVDGEVV DGTSTIDEGM VTGESVPVKK QPGDEVIGAT
INKTGSFKFR ATRVGSDTVL AQIVQLVQQA QGSKAPIQRL ADQVTGWFVP AVIAIALLTF IIWFNFTG--
---------- ---------- NVTLALITTV GVLIIACPCA LGLATPTSVM VGTGKGAENG ILIKGAESLE
LAHKIQTIVL DKTGTITQGK PTVTDFVTVN GTANGNEIR- ---------- ---------- LVQLAASVER
---------- NSEHPLAEAV VRYAQSQ--- ---------- ---------- -EVTLADVK- -EFEAVAGSG
VQGIVSD--- ---------- ---------- ---------- ---------- ---------S LVQIGTQRWM
SEL------- -GIDTQALQQ DKERLEYLGK TA---IWIAV DRQIQG---- -LMGISDAIK PTSIQAISAL
QKLGLEVVML TGDNRRTAET IAREVGIK-- RVLAEVRPDQ KAATVQKLQS EG-------K IVAMVGDGIN
DAPALAQADV GMAIGTGTDV AIAASDITLI SG------DL RSIVTAIQLS RATIRNIRQN LFFAFIYNVA
GIPIAAGILF PIFGWLLNPI IAGAAMAFSS VSVVTNALRL RKFQAKPVA- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----MAQTIN
LQLEGMRCAA CASSIERAIA KVP------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---GVQSCQV NFAL------ ---------- ----------
---EQAVVSY HG-------- ---------- ---------- ---------- ---------- ----------
-ETTPQILTD AVERAG---- YHARVLKQQ- -VLSSQQTE- ---------- ---------- ---DRKP---
---VFSAKLV TGLVISAVLF FGSLPM---- ---------- ----MLGVNI PHFPHIFHDP --WLQWLLAT
PVQFWSGAEF YRG--AWKSV R-----TRSA TMDTLVALGT SAAYFYSVAI TLFPQWLTSQ G-------LA
AHVYFEAAAV VITLILLGRS LEQRARRETS AAIRKLMGLQ PQTALVKRGE H--------- ----------
---------- WETVAIAELA INDVVRVRPG EKIPVDGVVV AGNSTVDESL VTGESFPVDK TVGTEVIGAT
LNKSGSLDIQ VSKLGQDSVL AQIIQLVQQA QASKAPIQHF VDRITHWFVP TVIVVAIAAF CIWWLTTG--
---------- ---------- NITLAVLTLV EVLIIACPCA LGLATPTSVM VGTGKGAEYG VLIKEASSLE
MAEKLTAIVL DKTGTLTQGK PSVTNFFTLS PTSTEESLQ- ---------- ---------- LIQWAASVEQ
---------- YSEHPLAEAV VNYGQSQ--- ---------- ---------- -QVSLLEID- -NFQAIAGCG
VAGQWQG--- ---------- ---------- ---------- ---------- ---------Q WIRLGTSNWL
TDLGVT---- -GTEHQPWQS QAQQWEKEQK TV---IWLAV DTEVKA---- -LLAIADAIK PSSPQVVQAL
KKLGLSVYML TGDNQATAQA IADTVGIR-- HVLAQVRPGD KAQQVEQLQQ KG-------N IVAMVGDGIN
DAPALAQADV GIAIGTGTDV AIAASDITLI AG------DL QGILTAIKLS RATMGNIRQN LFFAFIYNVI
GIPVAAGLFY PLFGLLLNPI LAGAAMAFSS VSVVTNALRL KKFCP----- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- --MTALKQTE KSTSLPMSFD
FDIEGMTCAS CVRRVEKAIA AVPGVASANV NLATERATVQ FN-GVPETTS VLRAVEKAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- APRIVTEEIQ
IEGMTCASCV SRVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALK AVPGVADASV NLAT------ ---------- ----------
---EKATVRL VSG------- ---------- ---------- ---------- ---------- ----------
-SAEISALAA AVKGAG---- YGIR---KAT PAEAMKEDV- ---------- ---------- ---DHRTAEL
RSLKSAVTIS SLMTLPLFLL EMGSHF---- ---------- ----IPGVHD FIMGTIGMRN NLYLQFALAT
LVLFGPGLRF FRK--GVPNL L-----RWTP DMNSLVVLGT TAAWGYSVVT TFVPAILPSG ---------T
ANVYYEAAAV IVTLILVGRY LESRAKGRTS QAIKRLVGLQ PKTAFVLHSG E--------- ----------
---------- FVETEITEVV TGDVIRIRPG EKIPVDGTVT DGSSYVDESM ITGEPVPVQK ATDSAVIGGT
INKTGSITFK ATKVGSDTLL AQIIRLVEAA QGSKLPIQAL VDRVTAWFVP VVILAALLTF AAWYVLGP--
---------- --------SP ALSFALVNAV AVLIIACPCA MGLATPTSIM VGTGRAAELG ILFRKGEALQ
SLRDADVVAV DKTGTLTKGR PELTDLVAAE GFEPD---E- ---------- ---------- VLCLVASLET
---------- LSEHPIAEAI VSAAKSR--- ---------- ---------- -GIATVAVS- -AFEATPGFG
VSGTVSG--- ---------- ---------- ---------- ---------- ---------R RVLVGADRAL
VKN------- -GIDITGFAD EAERLGSGGK SP---LYAAI DGRLAA---- -IVAVSDPVK ESTPQAIKSL
HALGLKVAMV TGDNRRTAEA IAKKLGID-- EVVAEVLPEG KVDAVRKLRQ GG-------R SVAFIGDGIN
DAPALAEADV GIAVGTGTDI AIESADVVLM SG------DL NGVAKALALS KATIRNIKQN LFWAFVYNIS
LVPVAAGVLY PVNGTLLSPI FAAAAMAMSS VFVLGNALRL KSFDPA---- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- --MTALKKIE KAAPLPVSTN
FGIEGMTCAS CVRRVEKAIT AVPGVASANV NLATERATVQ FD-GEPDTLA VLHAIEKAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- APRIATEELQ
IEGMTCASCV SRVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALK AVPGVADAAV NLAT------ ---------- ----------
---EKATVSL ISG------- ---------- ---------- ---------- ---------- ----------
-TADLSALEA AVRGAG---- YELR---KTK PAEASAGDE- ---------- ---------- ---DHRAAEL
GSLKSAVTIS VLMTLPLFLM EMGSHF---- ---------- ----ISGVHE LIMGTIGMRN NLYLQFALAT
LVLFGPGLRF FRK--GVPNL L-----RWTP DMNSLVVLGT TAAWGYSVVA TFVPRVLPSG ---------T
ANVYYEAAAV IVTLVLLGRY LESRAKGRTS QAIKRLVGLQ PKTAFVLRGG E--------- ----------
---------- FVEAQISEVV AGDVIRIRPG EKIPVDGTVI DGSSYVDEAM ITGEPLPVQK TADSAVVGGT
INKTGSITFK ATKVGSDTLL AQIIKLVETA QGSKLPIQAL VDRVTGWFVP AVILAAVLTF AAWYTFGP--
---------- --------SP ALSFALVNAV AVLIIACPCA MGLATPTSIM VGTGRAAELG ILFRKGEALQ
RLRDADVVAL DKTGTLTKGR PELTDLVAAE GFEAD---E- ---------- ---------- VLFLVASLET
---------- LSEHPIAEAI VSAAKSK--- ---------- ---------- -GIATAAVN- -GFEATPGFG
VSGSVSG--- ---------- ---------- ---------- ---------- ---------R QVLVGADRAL
ATN------- -GIDVSGFST EAELLGASGK SP---LYAAI EGRLAA---- -IVAVSDPVK ETTPQAIRSL
HELGLKVAMI TGDNRRTAEA IARKLGID-- EVVAEVLPEG KVEAIRKLRQ GG-------R SVAFIGDGIN
DAPALAEADV GIAVGTGTDI AIESADVVLM SG------DL NGVAKAIALS KATILNIKQN LFWAFAYNVS
LIPVAAGVLY PVTGILLSPI FAAAAMAMSS VFVLGNALRL KSVNPA---- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- -------MRM SQMEIRASHQ
IAIDGMTCAS CVGRVEKAIA RVPGVLKASV NLATERADIS FS-GPPDVPA VIAAVRHAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- GVEEKTVELD
IEGMTCASCV GRVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALK AVSGVSDASV NLAT------ ---------- ----------
---ERAAIRV AGN------- ---------- ---------- ---------- ---------- ----------
-AASAATLAE AIKRAG---- YQAK---EIV ADKAGDAEQ- ---------- ---------- ---DRRAADM
RSLKISLAVA VVLTLPVFVL EMGSHL---- ---------- ----VPAIHD FVMETVGMRK SWYLQFVLTT
LVLFGPGLRF FKK--GIPAL M-----RLAP DMNSLVVLGT AAAWGFSVVA TFLPEILPRG ---------T
ANVYYEAAAV IVTLILLGRF LEARAKGRTS EAIKRLVGLQ AKSARVLRDG E--------- ----------
---------- TIDVPLQDVR TGDVIVVRPG EKVPVDGLVL NGSSYVDESM ITGEPVPVTK TEGSEVVGGT
VNRNGSFTFR ATKVGSDTLI AQIIRMVEEA QADKLPIQAL VDKVTNWFVP AVMLAALVTF AVWFVFGP--
---------- --------DP ALTFALVNAV AVLIIACPCA MGLATPTSIM VGTGRAAEMG VLFRRGDALQ
TLRDADVIAV DKTGTLTLGK PKLVHFNTTQ GFDAD---E- ---------- ---------- VLRLVASLEN
---------- RSEHPIAEAI VEAAKHG--- ---------- ---------- -GLTLAEAE- -AFEATPGFG
VAATVDG--- ---------- ---------- ---------- ---------- ---------R RVEAGADRFM
VKL------- -GYDVGAFAT DAERMGREGQ SP---LYAAV DGRLAA---- -IIAVADPIK QTTPEAIAAL
HALGLKVTMI TGDNRRTAEA IARRLGID-- EVVAEVLPDG KVEAVKRLAA GG-------R RVAFVGDGIN
DAPALAAADV GLAIGTGTDV AIESADVVLM SG------DL RGVANAIALS KATIRNIRQN LFWAFAYNAA
LVPVAAGILY PVNGVLLSPV LAAGAMALSS VFVLTNALRL KSFRAPLVDR SSDLQLAAAE ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- -------MNK TVKPEAVSFP
VPVEGMSCAS CVSSVEKAVS RVPGVDKVSV NLATERADVT FK-GTPDLPA VIEAIRKAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- DVPAGSVDLA
IEGMSCASCV SKVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALS GVPGVTRASV NLAT------ ---------- ----------
---ERAHVEL AG-------- ---------- ---------- ---------- ---------- ----------
-QVALSELIK AVEKAG---- YEAHALDEAR SDARAEAQS- ---------- ---------- ---EKRDAEA
AELKKSVILA AILTLPVFIL EMGSHL---- ---------- ----IPAVHM FVMDRIGMQN SWYLQFVLTT
LVLFGPGLRF FKK--GVPTL L-----RGTP DMNSLVVVGT FAAWGFSVVA TFLPGALPEG ---------T
VNVYFEAAAM IVTLILIGRY LEARAKGRTS AAISRLVGLQ AKSARVVRDG Q--------- ----------
---------- AIDVPLEDVR AGDIVQVRPG EKVPVDGEVI EGASYVDESM ITGEPVPVAK EKGAAVVGGT
INKTGAFTFR ATKVGHDMVI SQIIRMVQDA QADKLPIQAM VDKVTGWFVP AVMAAAAITF VLWLAIGG--
---------- --------TA MMGYALVNAI AVVIIACPCA MGLATPTSIM VGTGRAAEFG VLFRRGDALQ
TLRDASVIAV DKTGTLTEGK PALAHFDTVE GFDKD---E- ---------- ---------- LLALVAAVEA
---------- RSEHPIADAI VAAAQEK--- ---------- ---------- -GLKLAEVS- -AFEAVPGFG
LKASVGG--- ---------- ---------- ---------- ---------- ---------R EVAIGADRYT
AKL------- -GADVAVFAE DAKRFGDEGQ SP---LYAAV DGRLAA---- -ILTVADPMK ETTPAAIAAL
HAQGLKVAMI TGDNRRTAQA IARKLGID-- EVVAEVLPDG KVAALKRLSA GG-------K RIAFVGDGIN
DAPALAAADV GLAIGTGTDI AIESADVVLM SG------DL RGVVNAIAIS KATIRNIGEN LFWAFAYNVA
LIPVAGGILY PFTGTLLSPV LAAGAMALSS IFVLSNALRL RRLRLAVQ-- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ------MNTP TTLSSANRLS
LPVEGMTCAS CVGRVERALK AVPEIKDAVV NLATERADIT FS-STPNPVL AVSAIESSGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- KVPEEITELA
IEEMTCASCV GRVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALA QIPGVLEATV NLAT------ ---------- ----------
---ERARVRH LSG------- ---------- ---------- ---------- ---------- ----------
-VVSITDLEV AVVHAG---- YKPRR-LSDN PANTRDLSE- ---------- ---------- ---ERREKEA
RSLRRALLIA TIFTLPVFVI EMGSHF---- ---------- ----IPGVHH WVTQTLGQQL NWYIQFVLAT
IVMFGPGLRF FKK--GIPAL L-----RGAP DMNSLVSVGT VAAYGYSVVS TFIPQVLPAG ---------T
ANIYFEAAVV IVTLILLGRN LEAKAKGNTS QAIKRLVGLQ AKTARVSRHG E--------- ----------
---------- ILEIPLDQVM MGDIVVVRPG EKIPVDGEVV EGHSYVDESM ITGEPVPVAK EIGAEVVGGT
INKTGTFSFK VTKVGANTIL AQIIRLVEEA QGSKLPIQAL VDKVTMWFVP AVMIGATITF FIWLAFGP--
---------- --------EP ALTFALINAV AVLIIACPCA MGLATPTSIM VGTGRAAELG ILFRKGEALQ
ALRDVSVVAL DKTGTLTKGR PELTDLIPAE KFEYN---E- ---------- ---------- ILSLVASIET
---------- YSEHPIAQSI VNAANEA--- ---------- ---------- -KLTLASVD- -NFEAIPGFG
VSATVDG--- ---------- ---------- ---------- ---------- ---------R SVSVGADRFM
KQL------- -GLDVSQFAS SAQKLGEQGK TP---LYTAI DGRLAA---- -IIAVADPIK ETTPEAIKAL
HALGLKVAMI TGDNKATAKA IAKQLGID-- EIVAEVLPDG KVAALKQLSQ KG-------D KVAFVGDGIN
DAPALAQADV GLAIGTGTDV AIEAADVVLM SG------DL RGVVDAIALS QATIRNIKQN LFWTFAYNAL
LIPVAAGMLY PINGMLLSPI FAAAAMALSS VFVLGNALRL KRFQAPMKTH ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-FLKKDLILS VLLTLPVFIL EMGSHL---- ---------- ----IPAFHT FMMDNIGQQN SWLMQFFLTT
VALIFPGRRF FKK--GIPSL F-----RLAP DMNSLVAVGT LAAYLYSVVA TFFPSVQPQG ---------T
VNVYYEAAAV IITLILLGRF FEAKAKGRTS LAIQHLVGMQ PKVARIQLNN Q--------- ----------
---------- EIEVPIAEVQ TGTIVEIRPG ERIPVDGEVI HGQSFIDESM ITGEPMPVAK NDGSTVVGGT
INQSGRLNIK ATSVGSSSVL SQIIRMVEQA QGSKLPIQAL VDKITMWFVP VVMGLSLLTF ITWFIFGP--
---------- --------EP ALTFSLVNAV AVLIIACPCA MGLATPTSIM VGTGRGAEMG VLFRKGEALQ
LHKETKVVAV DKTGTLTEGK PILTDLHVLE GFEYN---A- ---------- ---------- VLSLMAAVES
---------- KSEHPIARAI VQAAIDK--- ---------- ---------- -ELILSPVA- -DFKSVTGYG
IEATVSE--- ---------- ---------- ---------- ---------- ---------H LVHIGADRYM
EKL------- -GLNPNVFSQ FSDRLGEEGK TP---LYVAI DQKLAA---- -IIAVADPIK ESTFAAIEAL
HQLGLKVAMI TGDNRHTAQA IAKKLGID-- EVIAEVLPEG KIEAVKKLKN QY-------G KLAYVGDGIN
DAPALAEADI GLAIGTGTDV AIEAADVVLM SG------FL KGVPNAIALS KATITNIREN LFWAFVYNAA
LIPIAAGVLY PQFGLLLSPV FAAGAMALSS IFVLGNALRL KRFKAPLAII ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ------MSQS ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ENRHDTISLL
IEGMTCASCV ARVEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------GIK AVPGVTDATV NLAT------ ---------- ----------
---ERATV-- -RG------- ---------- ---------- ---------- ---------- ----------
-TASAEAVIA AIEKTG---- YKARP--IET AGQGEDDSE- ---------- ---------- ---EKKEAER
VRLKRDLILA SVLALPVFVL EMGSHL---- ---------- ----IPGMHE WVIKTIGLQQ SWYWQFALTL
LVLTIPGRRF YLK--GFPAL A-----RLAP DMNSLVAVGT AAAFGYSLVA TFTPDLLPEG ---------T
VNVYYEAAAV IVALILLGRF LEARAKGRTS EAIKRLVGLQ ARVAHVLREG R--------- ----------
---------- IVDIPVDEVV LGDCVEVRPG ERIPVDGEVT EGRSFVDESM ITGEPIPVEK SAGSAVVGGT
VNQKGALTLR ATAVGGQTML AQIIRLVEQA QGSKLPIQAV VDKVTLWFVP MVMLIAALTF VVWLAFGP--
---------- --------SP ALTFALINGV AVLIIACPCA MGLATPTSIM VGTGRGAEMG VLFRKGEALQ
LLKDAKVVAV DKTGTLTEGR PVLTDLDVAS GFERR---E- ---------- ---------- VLAKVAAVES
---------- RSEHPIARAI VVSAEEE--- ---------- ---------- -GIALPGMS- -GFESVTGMG
VYATVDG--- ---------- ---------- ---------- ---------- ---------T RVDVGADRYM
REI------- -GVDISGFAT TAERLGQEGK SP---LYAAI DGQLAA---- -IIAVADPIK PSTPAAINAL
HQLGIKVAMI TGDNARTAQA IARQLGID-- DVVAEVLPEG KVEAIRRLKA AY-------G QVAFVGDGIN
DAPALAESDV GLAIGTGTDV AVESADVVLM SG------NL QGVPNAIALS KATIRNIHQN LFWAFAYNTA
LIPVAAGALF PVWGILLSPV FAAGAMAMSS VFVLGNALRL RRFRAPMATP SDTSTT---- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -----MKTLD
LDISGMTCAA CVGRVERGLR KVEGVQEAHV NLATERASVT YDPALTNAAA LVQKVVDTGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- DAPTAELSFP
VAGMTCAACV GRVER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALN KTDGVLDASV NLAT------ ---------- ----------
---ERASVRY LPA------- ---------- ---------- ---------- ---------- ----------
-SVSPAELKS AVVNAG---- YDVPE-EQTQ AASRLELER- ---------- ---------- ---ARKAEEL
AGLRRSLTFS AVFSVPLLLL SMVPML---- ---------- ----YPLLHH WLLGTLGERA MNVLMLLLAA
PVQFGPGLRF YRT--GWAAL R-----HRSP DMNTLVMLGT SAAFFYSLAV TLWPQLFPAG ---------S
RHVYFEASAV VITLILLGKY FEALAKGRSS EAMRTLLQLQ PQSARVQRGT E--------- ----------
---------- VVEVPVDGVR VGDTVLVRSG ERLPVDGEVL SGESYVDESM LTGESVPVHK AAGAKVTGGT
VNGTGSLTFR ATGVGADTAL ARIIRLVEDA QASRPPIQGL ADRVVAQFVP LVLAIALVTF LAWLYVGG--
---------- --------PS ALSNALIHTV AVLIIACPCA MGLATPVSIM VGSGRAAQLG VLFRSGAALE
GLGEAQTVAL DKTGTVTRGV MEVTDVVVDG RWVMGDG-E- ---------- ---------- LLRLAAIAEG
---------- PSEHPLARAI ERAATLSPSP LAGEGLAQPG VRGRVTNEPA PSPTLPQPS- -SFQALPGYG
LRAEVDG--- ---------- ---------- ---------- ---------- ---------R RVEIGAARFM
AQL------- -GLPLGELGA KADELAARAR TP---VFAAV DGQLAG---- -LLGVADPIR EGSAEAIRTL
TAQGLDVAMV TGDARATAEA VAREAGVN-- RVLAEVLPEG KAQAVAELQQ CG-------Q RVAFVGDGIN
DAPALAGADV GVAIGTGTDV AVETADVILL GG------DL RSVPNAVALS RAVIRNIKLN LFWAFAYNVL
LIPVAAGVLA P-WGLGLSPV LAAAAMGLSS VFVMSNALRL RGFTPPLSVK G--------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- MNSATLTELD
LPVSGMTCAS CAGRVERALK KVPGVAAASV NLASEQARVQ AP--ADSLPA LVAAVEQAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- QVPARSLELS
IEGMTCASCV GRVER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALK KVPGVREVSV NLAS------ ---------- ----------
---ERAHLEL LG-------- ---------- ---------- ---------- ---------- ----------
-AVDSQALLQ AVEQAG---- YKAR--LLDA GQPRQDDAE- ---------- ---------- ---RRLRRER
WWVIAALLLA LPLVLPMLVE WAGLHW---- ---------- ----MLPP-- ---------- --WAQFLLAT
PVQFVIGARF YVS--AWRAV K-----AGAG NMDLLVALGT SAGYGLSVYL --WLTAPPGH ---------M
PHLYFEASTV VIALILLGKY LESRAKRQTA SAIRALEALR PERAVRLRDG R--------- ----------
---------- EEEVAIAELR LGDEVVVRPG ERFPVDGEVL DGSSHADEAL ITGESLPVPK APGDKVTGGA
INGEGRLLLR TTALGGETVL AKIIRLVEDA QAAKAPIQKL VDKVSQVFVP VVILIALVTL GAWLVAG---
---------- ---------V GLEQALVNAV AVLVIACPCA LGLATPTAIM AGTGVAARHG ILIKDAESLE
VAHAVTSVAF DKTGTLTSGR PQIIHLGGDD --QEQ----- ---------- ---------- LLRLAGALQR
---------- GSEHPLAKAV LERCAER--- ---------- ---------- -DLEVPPVN- -ASQALSGRG
IQGEVEG--- ---------- ---------- ---------- ---------- ---------R RLALGNRRLL
DEQ------- -ELKPGALAS AAADWEAEGR TLSWLLELAP EKRVLG---- -LFAFGDSLK DGAAEAVEAL
RGRDIHSHLI TGDNRGSAAV VAKALGID-- DVHAEVLPAD KAATVAELKG RG-------R VVAMVGDGIN
DAPALAAADV GIAMGGGTDV AMHAAGITLM RG------DP RLVPAALDIS RRTYAKIRQN LFWAFIYNVI
GIPLAA---- ---FGLLNPM VAGAAMAFSS VSVVGNALLL RRWKP----- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- --MPASTTYD
LPISGMTCAS CAGRVERALR KVTGAEQVSV NLTTEKARVL AP--PASLPA LVEAVREAGY ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- GVPTRTLELQ
IGGMTCASCV GRVER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------ALG KLAGVEQVSV NLAS------ ---------- ----------
---ERAHLEV LA-------- ---------- ---------- ---------- ---------- ----------
-ALDDNLLID AVQKAG---- YSAS--LPQS TKDDQSAVQ- ---------- ---------- ---RRLRNER
LAVGAALLLA LPLVLPMLVQ PFGLHW---- ---------- ----MLPA-- ---------- --WAQFLLAT
PVQFILGARF YIA--AWKAV R-----AGAG NMDLLVALGT SAGYGLSLYQ --WAQAPAGM ---------A
PHLYFEASAV VIALVLLGKY LESRAKRQTA SAIRALEALR PERALRVVDG V--------- ----------
---------- EEDVAIAHLR VGDLVLVKPG ERFPVDGVVE DGSSHADEAL ISGESLPVPK QPGDSVTGGA
INGEGRLLVR TQALGTETVL ARIIRLVEDA QAAKAPIQKL VDRVSQVFVP AVLVLALITL IGWWLAG---
---------- ---------V PLETALINAV AVLVIACPCA LGLATPAAIM AGTGVAARHG ILIKDAEALE
RAHAVNRVVF DKTGTLTSGS PQVVHSQALD GNSAD----- ---------- ---------- LYRLAGALQR
---------- GSEHPLAKAV LVACAEQ--- ---------- ---------- -GLDVPTVA- -DSQSLTGRG
IAGRVEG--- ---------- ---------- ---------- ---------- ---------R ELALGNRRLL
DES------- -GLQPGELAA QAQAWEAEGR TLSWLIERGK QPRVVG---- -LFAFGDSLK PGAAQAIETL
HAQHISSHLL TGDNRGSANV VAEALGID-- DVHAEVLPAD KAATVAALKQ EG-------- VVAMVGDGIN
DAPALAAADI GIAMGGGTDV AMQAAGITLM RG------DP RLVPAALEIS RKTYAKIRQN LFWAFIYNLI
GIPLAA---- ---LGYLNPV LAGAAMALSS VSVVSNALWL KTWKPTSSTQ EAP------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- --MQDITTFD
LPISGMTCAS CAGRVERALA KVP------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---GVNSVTV NLAN------ ---------- ----------
---ERAHVSV AP-------- ---------- ---------- ---------- ---------- ----------
-QTDPHTLIS AVTRAG---- YGAT--LIQD RQADAEKKI- ---------- ---------- ---QHLHRER
WALLLAIALA LPLIAPMLLT PLGVHW---- ---------- ----MLPA-- ---------- --WAQFALAT
PVQFILGARF YLA--AWKAV R-----AGAG NMDLLVAIGT SAGYGLSVYQ --WLHAAPGT ---------T
PHLYFEASAV VIALVLLGKY LESRAKRQTA SAIRALEALR PDRALRLIDG I--------- ----------
---------- EQDVAISELR LGDAVLVKPG ERFPVDGEVL EGRSHADEAL ITGESLPVAK QPGDKVTGGA
INGEGRLLIR TAALGAETVL ARIIRLVEDA QAGKAPIQKL VDKVSQVFVP TVLVIAFFTL AGWLLVG---
---------- ---------A SLEVALINAV AVLVIACPCS LGLATPTAIM AGTGVAARYG ILIKDAEALE
RAHDVDAVVF DKTGTLTSGT PRITNMSAVL GNEEH----- ---------- ---------- LLQLAGALQR
---------- GSEHPLAKAV LDVCDEW--- ---------- ---------- -QLTLDPVE- -NSHALSGRG
IAGTVQG--- ---------- ---------- ---------- ---------- ---------R ELALGNRRLL
DES------- -GLPMGDLAE SARIWEADGR TLSWLIEQAP EPKVIG---- -MFAFGDTLK PGTDQAIRAL
NARGITSHLL TGDNRGSAQM VARALGIH-- DVHAEVLPAD KADTVMRLKS NH-------- VVAMVGDGIN
DAPALAAADV GIAMGGGTDV AMHAAGITLM RG------DP RLVPAALDIS QRTYAKIRQN LFWAFVYNLI
GIPLAA---- ---LGYLNPV LAGAAMALSS VSVVGNALLL KTWKPRNLED KP-------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -MS--EEVFL
IDGMTCASCA INVEN----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------AVK KLDGIESAVV NLTT------ ---------- ----------
---EKMTIDY DAA------- ---------- ---------- ---------- ---------- ----------
-KVSEADVTK AVAGAG---- YGAKVYDPTT AESQKDREE- ---------- ---------- ---HKLAGIK
KRLLWTSIFT IPLFYIAMGS MVG------- ---------- -----LPLPN FLAPSSAPLT YAMVLLLLTI
PVIVLSW-SF YDN--GFRSL F-----KGHP NMDSLVSLAT TAAFLYSLYG TYHVYLGH-- ------THHA
HHLYYESVAV ILTLITLGKY FETLSKGRTS DAIKKLMHLS AKEATLIRDG ---------- ----------
---------E EIKVPIEQVQ IRDQILVKPG EKIPVDGRVL SGHSAIDESM LTGESIPIEK MADSPVYAGS
INGQGSLTFE AEKVGNETLL SQIIKLVENA QQTKAPIAKI ADKVSAVFVP VIITIAILTG LFWYFVM---
---------- --------GQ DFTFSMTISV AVLVIACPCA LGLATPTAIM VGTGRAAENG ILYKRGDVLE
LAHQINTIVF DKTGTITQGK PEVVHQFSYH ---DRT--D- ---------- ---------- LVQVTAALEA
---------- LSEHPLSQAI VDYAKKE--- ---------- ---------- -GTHLLAVD- -DFTSLTGLG
LKGCVAD--- ---------- ---------- ---------- ---------- ---------E TLLVGNEKLM
RQAN------ --ISLEQAQA DFKAATAQGQ TP---IFVAS DGQLLG---- -LITIADKVK NDSAATVKAL
QNMGVEVAML TGDNEETAQA IAKEVGIT-- FVISQVFSQE KTQAILDLQA EG-------K KVAMVGDGIN
DAPALATADI GISMGSGTDI AMESADIVLM KP------AM LDIIKALKIS RVTIINIKEN LFWAFIYNVL
SVPIAMGVLY LFGGPLLDPM IAGLAMSFSS VSVVLNALRL KVVKL----- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -MS--EEVFL
IDGMTCASCA INVEN----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------AVK KLDGIESAVV NLTT------ ---------- ----------
---EKMTIDY DAA------- ---------- ---------- ---------- ---------- ----------
-KVSEADVTK AVAGAG---- YGAKVYDPTT AESQEDREE- ---------- ---------- ---HKLAGIK
KRLLWTSIFT IPLFYIAMGS MVG------- ---------- -----LPLPN FLAPSSAPLT YAMVLLLLTI
PVIVLSW-SF YDN--GFRSL F-----KGHP NMDSLVSLAT TAAFLYSLYG TYHVYLGH-- ------THHA
HHLYYESVAV ILTLITLGKY FETLSKGRTS DAIKKLMHLS AKEATLIRDG ---------- ----------
---------E EIKVPIEQVQ IGDKILVKPG EKIPVDGRVL SGHSAIDESM LTGESIPIEK MADSPVYAGS
INGQGSLTFE AEKVGNETLL SQIIKLVENA QQTKAPIAKI ADKVSAVFVP VIITIAILTG LFWYFVM---
---------- --------GQ DFTFSMTISV AVLVIACPCA LGLATPTAIM VGTGRAAENG ILYKRGDVLE
LAHQINTIVF DKTGTITQGK PEVVHQFSYH ---DRT--D- ---------- ---------- LVQVTASLEA
---------- LSEHPLSQAI VDYAKKE--- ---------- ---------- -GTRLLAVE- -DFTSLTGLG
LKGCVAD--- ---------- ---------- ---------- ---------- ---------E TLLVGNEKLM
RQEN------ --ISLEQAQA DFKAATAQGQ TP---IFVAS DGQLLG---- -LITIADKVK NDSAAAIKAL
QNMGVEVAML TGDNEETAQA IAKEVGIT-- FVISQVLPQE KTQAILDLQA EG-------K KVAMVGDGIN
DAPALATADI GISMGSGTDI AMESADIVLM KP------AM LDIIKALKIS RATIINIKEN LFWAFIYNVL
SVPIAMGVLY LFGGPLLDPM IAGLAMSFSS VSVVLNALRL KVVKL----- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -MANRKETFL
IDGMTCASCA LTIEK----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------AVN KLDHVDSAVV NLAT------ ---------- ----------
---EKMTVTF DDT------- ---------- ---------- ---------- ---------- ----------
-TLSPNVIEE CVSESG---- YEASLFKEET SKSQSERHQ- ---------- ---------- ---LAIEKMW
HRFWMSAVAT IPLLYISMGP MIN------- ---------- -----LWLPS FLMPDKGPLN YGMIQLLLTL
PVMYFGR-IF YQN--GFKAL F-----KRHP NMDSLVAIAT TAAFIYSLYG LYEILQGD-- ------IHYA
HQLYFESVAV ILTLITLGKY FEILSKGRTS ASIEKLLTLS AKEARVIKDG ---------- ----------
---------E DYMVPLDKVK IGETILVKPG EKIPLDGHVV AGESSIDESM LTGESIPVEK KVGSKVYGAS
INGQGSLTIF VEKEAGGSLL SQIINLVEAA QTSKAPIANL ADKVSGVFVP FVIVIAILSG LSWYLIL---
---------- --------GQ SFAFSLKIMI AVLVIACPCA LGLATPTAIM VASGKAAENG ILFKGGEVLE
KAHHIDTIVF DKTGTLTKGK PEVVAIKTYG G--DKE--E- ---------- ---------- FLGQVASVEK
---------- LSNHPLSQTI VNKAKEK--- ---------- ---------- -ELPLREVM- -AFKNILGYG
LSATING--- ---------- ---------- ---------- ---------- ---------K TMLVGNANLM
TKND------ --VNLDLAKA DIEIAQEEAQ TV---VYVSE NGVLSG---- -LITLTDQLK TDSQETVKQL
QRLGFNLVLL TGDNKASADA IAQKLGIT-- TVVSEVLPDQ KANVILELKE KG-------G QIAMVGDGIN
DAPALASSDV GISMSSGTDI AIESADIVLM KP------EL TDLLKAMTIS KQTIQIIKEN LFWAFFYNVL
AIPVAMGVLH LFGGPLLNPM LAGLAMAFSS VSVVLNALRL KVLK------ ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -----MDTKT
LRIEGMTCAA CARAVERATK KLEGVEEANV NLATEKLTVS FQDDKVSVPN IQEAIEKAGY KA--------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- LTEATNKTLA
IGGMTCAACA KTVER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------VTS KLEGVTSSSV NLAT------ ---------- ----------
---EKLSISF EAS------- ---------- ---------- ---------- ---------- ----------
-KVSINDIKQ AIEKAG---- YKAS-EEVES VDTDKERKE- ---------- ---------- ---KVIKNLW
KRFIISAVFA VPLLIIAMVP MIFNSI---- ---------- ----GVMLPS AIDPMNNEKI YGVLELILVL
PVMFQGR-KF FQV--GFKTL I-----KRSP NMDSLVAIGS SAAFVYSLFG LYQIFTG--- -------ING
AQLYFESAGI ILTLITLGKY MEAVSKGKTS EAIKKLVGLT PKTALVVKGE ---------- ----------
---------K EEEVAIEEVK PGDVVIVKPG SKIPVDGIVI EGNTSIDESM LTGESIPVSK GPGDEVIGAS
INKNGSIKYK VTKVGKDTVL SQIVKLVEDA QGSKAPIAKL ADIVSGYFVP VVITLAIISS LAWYLS----
---------- --------GE NLTFTLTIFI SVLVIACPCA LGLATPTAIM VGTGKGAEYG VLIKNGTALE
NTHKIKTIVF DKTGTITEGK PKVTDIKAID EV-SEE--E- ---------- ---------- LLKIAASVEK
---------- ASEHPLGEAI VKEAEFK--- ---------- ---------- -GMEFLKVS- -DFKSVTGHG
IEALIDS--- ---------- ---------- ---------- ---------- ---------K RVLLGNKKLM
DNNN------ --IEVKSVLD YVDDLAKQGK TP---MYIAI DKQVKG---- -IIAVADSVK ESSAKAIKKL
HDMGIEVAMI TGDNKRSADA IAKKVGID-- RVLAEVLPED KASEVKKLQA GG-------K KVAMVGDGIN
DAPALAQADI GMAIGKGTDI AMESADIVLM KS------DL MDVITAIELS KKTIKNIKEN LFWAFGYNVI
GIPVAMGILY IFGGPLLNPM IAAAAMSLSS VSVLTNALRL KRFKPEYML- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
-----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- ----MQVSFV
VHGISCTACV RRIEE----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------AVR HVTGAYDVYV NPTT------ ---------- ----------
---SHLYVHT DLHPTE---- ---------- ---------- ---------- ---------- ----------
HTLFAQTIID AVSHAG---- FKATLLDTHS TTAPLAATQP V--------- ---------- --HPDFVTLK
RRVRTSLCLL VPLMYLSMGH MVH------- ---------- -----LPIPG FLHPLKYALS FALVQAFLTL
PVLYANR-SL FRA--GLIAL YGAILRRNTA TMDSLISLGS LSSFTYGLFA TARIAMGVHA NDTALVSHYV
ADLYFESAAM IVTLVTVGKY LSALSKGRTS RALTQLLDIK PKTARVIRQV SVPRGASPS- ----SPTTAS AASAHETHEI
EIEIPAQDVL VGDTVLVKAG ELVPVDGIIT SGQATLDESN VTGESIPVEK GRGDSVISAS LVSTGFLKFR
AERVGEHTTL AQIISLVEKT AASKVPVTKL VDAVSAYFVP SIVALSLLSG CAWLCA---- ----------
--------GA SAEFAFSIAV TVLVISCPCV LGLAVPTALM VATGKGAQMG ILIKSAQVFQ QMARTKVIAF
DKTGTLTLGR PTLSHIHTLH PTYNEE--D- ---------- ---------- ILHLAYSLEV ----------
CSGHPLAAAI SVAAQRK--- ---------- ---------- -GMTPLAIT- -DFNSEQGLG LRARLVHTSY
---------- ---------- ---------- ---------- --------AK TVMVGNARMM VAH-------
---SIDGMDT YLSPSHNLEE TP---LFVAA DKNLVG---- -VLFVSDPVK VHSSAAIGAL HKRGIQTLML
TGDVKHVAHT IAARCGVK-- KSKAELLPHD KEREISALKA SG-------M MVAMVGDGVN DAPALASADV
GIAIGAGSDI AVESADVVLM RN------CI RDVVTLVDLS IATVRNMKQN LFWAFFYNTL GVPLAAGLGY
PFFGLRLTPM LAAAAMSLSS VSVLCNALRL NQFQSSSP-- ---------- ---------- ----------
---------- ---------- ---------- ---------- ---------- ---------- -----------
---------- ---------- -------MDP SMGVNSVTIS VEGMTCNSCV WTIEQQIGKV NGVHHIKVSL
E--EKNATII YDPKLQTPKT LQEAIDDMGF DAVIHNPDPL PVLTDTLFLT VTASLTLPWD HIQSTLLKTK
GVTDIKIYPQ KRTVAVTIIP SIVNANQIKE LVPEL----- --SLDTGTLE KKSGACEDHS MAQAGEVVLK
MKVEGMTCHS CTSTIEGKIG KLQGVQRIKV SLDNQEATIV YQPHLISVEE MKKQIEAMGF PAFVKKQPKY
LKLGAIDVER LKNTPVKSSE GSQQRSPSYT ND-------- STATFIIDGM HCKSCVSNIE STLSALQYVS
SIVVSLENRS AIVKYNASSV TPESLRKAIV AVSPGLYRVS ITSEVESTSN SPSSSSLQKI PLN---VVSQ
PLTQETVINI DGMTCNSCVQ SIEGVISKKP GVKSIRVSLA NSNGTVEYDP LLTSPETLRG AIEDMGFDAT
LS-------- ---------- --DTNEPLVV IAQPSSEMPL LTSTNEFYTK GMTPVQDKEE GKNSSKCYIQ VTGMTCASCV
ANIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------NLR REEGIYSILV ALMA------ ---------- ---------- ---GKAEVRY
NPAVIQPPMI AEFIR-ELGF GATVIENADE GD--GVLELV VRGMTCASCV HKIESSLTKH RGILYCSVAL
ATNKAH--IK YDPEIIGPRD IIHTIESLGF E----ASLVK -KDRSAS-HL DHKREIRQWR RSFLVSLFFC
IPVMGLMTYM MVMDHHFATL HHNQNMSKEE MINLHSSMFL ERQILPGLSV MNLLSFLLCV PVQFFGGWYF
YIQ--AYKAL K-----HKTA NMDVLIVLAT TIAFAYSLII LLVAMYERAK V--------N PITFFDTPPM LFVFIALGRW LEHIAKGKTS EALAKLISLQ ATEATIVTLD SDNILL---- ---------- ---------S
EEQVDVELVQ RGDIIKVVPG GKFPVDGRVI EGHSMVDESL ITGEAMPVAK KPGSTVIAGS INQNGSLLIC
ATHVGADTTL SQIVKLVEEA QTSKAPIQQF ADKLSGYFVP FIVFVSIATL LVWIVIGFLN FEIVETYFPG
YNRSISRTET IIRFAFQASI TVLCIACPCS LGLATPTAVM VGTGVGAQNG ILIKGGEPLE MAHKVKVVVF
DKTGTITHGT PVVNQVKVLT ESNRISHHK- ---------- ---------- ILAIVGTAES ----------
NSEHPLGTAI TKYCKQELDT ---------- ---------- ----ETLGTC IDFQVVPGCG ISCKVTNIEG
LLHKNNWNIE DNNIKNASLV QIDASNEQSS TSSSMIIDAQ ISNALNAQQH KVLIGNREWM IRNG------
----LVINND VNDFMTEHER KGRTAVLVAV DDELCG---- -LIAIADTVK PEAELAIHIL KSMGLEVVLM
TGDNSKTARS IASQVGIT-- KVFAEVLPSH KVAKVKQLQE EG-------K RVAMVGDGIN DSPALAMANV
GIAIGTGTDV AIEAADVVLI RN------DL LDVVASIDLS RKTVKRIRIN FVFALIYNLV GIPIAAGVFM
PIG-LVLQPW MGSAAMAASS VSVVLSSLFL KLYRKP---T YESYELPARS QIGQKSPSE- ----ISVHVG
IDDTSRNSPK LGLLDRIVNY SRASINSLL- ----SDKRSL NSVVTSEP-D KHSLLVGDFR EDDDTAL----
---------- ---------- -------MEP SMDVNSVTIS VEGMTCISCV RTIEQKIGKE NGIHHIKVSL
E--EKSATII YDPKLQTPKT LQEAIDDMGF DALLHNANPL PVLTDTLFLT VTASLTLPWD HIQSTLLKTK
GVTDIKIFPQ KRTLAVTIIP SIVNANQIKE LVPEL----- --SLETGTLE KRSGACEDHS MAQAGEVVLK
IKVEGMTCHS CTSTTEGKIG KLQGVQRIKV SLDNQEATIV YQPHLISVEE IKKQIEAMGF PAFVKKQPKY
LKLGAIDVER LKNTPVKSLE GSQQR-PSYP SD-------- STATFIIEGM HCKSCVSNIE SALPTLQYVS
SIAVSLENRS AIVKYNASSV TPEMLIKAIE AVSPGQYRVS IANEVESTSS SPSSSSLQKM PLN---VVSQ
PLTQETVINI SGMTCNSCVQ SIEGVVSKKP GVKSIHVSLA NSFGTVEYDP LLTAPETLRE VIVDMGFDAV
LP-------- ---------- --DMSEPLVV IAQPSLETPL LPSTND---- -----QDNMM TAVHSKCYIQ VSGMTCASCV
ANIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------NLR REEGIYSVLV ALMA------ ---------- ---------- ---GKAEVRY
NPAVIQPPVI AEFIR-ELGF GATVMENADE GD--GILKLV VRGMTCASCV HKIESTLTKH KGIFYCSVAL
ATNKAH--IK YDPEIIGPRD IIHTIGSLGF E----ASLVK -KDRSAS-HL DHKREIKQWR SSFLVSLFFC
TPVMGLMMYM MAMEHHFATI HHNQSMSNEE MIKNHSSMFL ERQILPGLSI MNLLSLLLCL PVQFFGGWYF
YIQ--AYKAL K-----HKTA NMDVLIVLAT TIAFAYSLII LLVAMYERAK V--------N PITSFDTPPM LFVFIALGRW LEHIAKGKTS EALAKLISLQ ATEATIVTLD SDNILL---- ---------- ---------S
EEQVDVELVQ RGDIIKVVPG GKFPVDGRVI EGHSMVDESL ITGEAMPVAK KPGSTVIAGS INQNGSLLIC
ATHVGADTTL SQIVKLVEEA QTSKAPIQQF ADKLGGYFVP FIVLVSIATL LVWIIIGFQN FTIVETYFPG
YSRSISRTET IIRFAFQASI TVLCIACPCS LGLATPTAVM VGTGVGAQNG ILIKGGEPLE MAHKVKVVVF
DKTGTITHGT PVVNQVKVLV ESNKIPRSK- ---------- ---------- ILAIVGTAES ----------
NSEHPLGAAV TKYCKQELDT ---------- ---------- ----ETLGTC TDFQVVPGCG ISCKVTNIEG
LLHKSNLKIE ENNTKNASLV QIDAINEQSS TSSSMIIDAP LSNAVDTQQY KVLIGNREWM IRNG------
----LVISND VDDSMIDHGR KGRPAVLVTI DDELCG---- -LIAIADTVK PEAELAVHIL KSMGLEVVLM
TGDNSKTARS IASQVGIT-- KVFAEVLPSH KVAKVKQLQE EG-------K RVAMVGDGIN DSPALAMANV
GIAIGTGTDV TIEAADVVFI RN------DL LDVVASIDLS RKTVKRIRIN FLFPLIYNLV GIPIAAGVFL
PIG-LVFQPW MGSAAMAASS VSVVLSSLFL KLYRKP---T YDNYELRTRS HTGQRSPSE- ----ISVHVG
IDDASRNSPR LGLLDRIVNY SRASINSLL- ----SDKRSL NSVVNSEP-D KHS------- -----------
---------- ---------- -------MDP SMGVNSVTIS VEGMTCNSCV WTIEQQIGKV NGVHHIKVSL
E--EKNATII YDPKLQTPKT LQEAIDDMGF DAVIHNPDPL PVLTDTLFLT VTASLTLPWD HIQSTLLKTK
GVTDIKIYPQ KRTVAVTIIP SIVNANQIKE LVPEL----- --SLDTGTLE KKSGACEDHS MAQAGEVVLK
MKVEGMTCHS CTSTIEGKIG KLQGVQRIKV SLDNQEATIV YQPHLISVEE MKKQIEAMGF PAFVKKQPKY
LKLGAIDVER LKNTPVKSSE GSQQRSPSYT ND-------- STATFIIDGM HCKSCVSNIE STLSALQYVS
SIVVSLENRS AIVKYNASSV TPESLRKAIE AVSPGLYRVS ITSEVESTSN SPSSSSLQKI PLN---VVSQ
PLTQETVINI DGMTCNSCVQ SIEGVISKKP GVKSIRVSLA NSNGTVEYDP LLTSPETLRG AIEDMGFDAT
LS-------- ---------- --DTNEPLVV IAQPSSEMPL LTSTNEFYTK GMTPVQDKEE GKNSSKCYIQ VTGMTCASCV
ANIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------NLR REEGIYSILV ALMA------ ---------- ---------- ---GKAEVRY
NPAVIQPPMI AEFIR-ELGF GATVIENADE GD--GVLELV VRGMTCASCV HKIESSLTKH RGILYCSVAL
ATNKAH--IK YDPEIIGPRD IIHTIESLGF E----ASLVK -KDRSAS-HL DHKREIRQWR RSFLVSLFFC
IPVMGLMTYM MVMDHHFATL HHNQNMSKEE MINLHSSMFL ERQILPGLSV MNLLSFLLCV PVQFFGGWYF
YIQ--AYKAL K-----HKTA NMDVLIVLAT TIAFAYSLII LLVAMYERAK V--------N PITFFDTPPM LFVFIALGRW LEHIAKGKTS EALAKLISLQ ATEATIVTLD SDNILL---- ---------- ---------S
EEQVDVELVQ RGDIIKVVPG GKFPVDGRVI EGHSMVDESL ITGEAMPVAK KPGSTVIAGS INQNGSLLIC
ATHVGADTTL SQIVKLVEEA QTSKAPIQQF ADKLSGYFVP FIVFVSIATL LVWIVIGFLN FEIVETYFPG
YNRSISRTET IIRFAFQASI TVLCIACPCS LGLATPTAVM VGTGVGAQNG ILIKGGEPLE MAHKVKVVVF
DKTGTITHGT PVVNQVKVLT ESNRISHHK- ---------- ---------- ILAIVGTAES ----------
NSEHPLGTAI TKYCKQELDT ---------- ---------- ----ETLGTC IDFQVVPGCG ISCKVTNIEG
LLHKNNWNIE DNNIKNASLV QIDASNEQSS TSSSMIIDAQ ISNALNAQQH KVLIGNREWM IRNG------
----LVINND VNDFMTEHER KGRTAVLVAV DDELCG---- -LIAIADTVK PEAELAIHIL KSMGLEVVLM
TGDNSKTARS IASQVGIT-- KVFAEVLPSH KVAKVKQLQE EG-------K RVAMVGDGIN DSPALAMANV
GIAIGTGTDV AIEAADVVLI RN------DL LDVVASIDLS RKTVKRIRIN FVFALIYNLV GIPIAAGVFM
PIG-LVLQPW MGSAAMAASS VSVVLSSLFL KLYRKP---T YESYELPARS QIGQKSPSE- ----ISVHVG
IDDTSRNSPK LGLLDRIVNY SRASINSLL- ----SDKRSL NSVVTSEP-D KHSLLVGDFR EDDDTAL----
---------- ---------- -------MEP SVDANSITIT VEGMTCISCV RTIEQQIGKV NGVHHIKVSL
D--EKSATII YDPKLQTPKT LQEAIDDMGF DALLHNANPL PVLTNTVFLT VTAPLTLPWD HVQSTLLKTK
GVTGVKISPQ QRSAVVTIIP SVVSASQIVE LVPDL----- --SLDMGTQE KKSGACEEHS TPQAGEVRLK
MKVEGMTCHS CTSTIEGKVG KLQGVQRIKV SLDNQEATIV FQPHLITAEE IKKQIEAVGF PAFIKKQPKY
LKLGAIDVER LKNTPVKSSE GSQQKSPSYP SD-------- STTMFTIEGM HCKSCVSNIE SALSTLQYVS
SIVVSLENRS AIVKYNASLV TPEMLRKAIE AISPGQYRVS IASEVESTAS SPSSSSLQKM PLN---IVSQ
PLTQEAVINI NGMTCNSCVQ SIEGVISKKP GVKSIHVSLA NSTGTIEFDP LLTSPETLRE AIEDMGFDAA
LP-------- ---------- --DMKEPLVV IAQPSLETPL LPSSNE---- -----LENVM TSVQNKCYIQ VSGMTCASCV
ANIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------NLR REEGIYSVLV ALTA------ ---------- ---------- ---GKAEVRY
NPAVIQPRVI AEFIR-ELGF GAMVMENAGE GN--GILELV VRGMTCASCV HKIESTLTKH KGIFYCSVAL
ATNKAH--IK YDPEIIGPRD IIHTIGSLGF E----ASLVK -KDRSAN-HL DHKREIKQWR GSFLVSLFFC
IPVMGLMVYM MVMDHHLATL HHNQNMSNEE MINMHSAMFL ERQILPGLSI MNLLSLLLCL PVQFCGGWYF
YIQ--AYKAL K-----HKTA NMDVLIVLAT TIAFAYSLVI LLVAMFERAK V--------N PITFFDTPPM LFVFIALGRW LEHIAKGKTS EALAKLISLQ ATEATIVTLN SENLLL---- ---------- ---------S
EEQVDVELVQ RGDIIKVVPG GKFPVDGRVI EGHSMVDESL ITGEAMPVAK KPGSTVIAGS INQNGSLLIR
ATHVGADTTL SQIVKLVEEA QTSKAPIQQF ADKLSGYFVP FIVLVSIVTL LVWIIIGFQN FEIVETYFPG
YNRSISRTET IIRFAFQASI TVLCIACPCS LGLATPTAVM VGTGVGAQNG ILIKGGEPLE MAHKVKVVVF
DKTGTITHGT PVVNQVKVLV ESNKISRNK- ---------- ---------- ILAIVGTAES ----------
NSEHPLGAAV TKYCKKELDT ---------- ---------- ----ETLGTC TDFQVVPGCG ISCKVTNIEG
LLHKSNLKIE ENNIKNASLV QIDAINEQSS TSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNG------
----LVISND VDESMIEHER RGRTAVLVTI DDELCG---- -LMAIADTVK PEAELAVHIL KSMGLEVVLM
TGDNSKTAQS IASQVGIT-- KVFAEVLPSH KVAKVKQLQE EG-------K RVAMVGDGIN DSPALAMANV
GIAIGTGTDV AIEAADVVLI RN------DL LDVVASIDLS RKTVKRIRIN FVFALIYNLV GIPIAAGVFL
PIG-LVLQPW MGSAAMAASS VSVVLSSLFL KLYRKP---T YDNYELHPRS HTGQRSPSE- ----ISVHVG
IDDTSRNSPR LGLLDRIVNY SRASINSLL- ----SDKRSL NSVVTSEP-D KHSLLVGDFR EDDDTTL----
---------- ---------- -------MEP SVDANSITIT VEGMTCISCV RTIEQQIGKV NGVHHIKVSL
D--EKSATII YDPKLQTPKT LQEAIDDMGF DALLHNANPL PVLTNTVFLT VTAPLTLPWD HVQSTLLKTK
GVTGVKISPQ QRSAVVTIIP SVVSASQIVE LVPDL----- --SLDMGTQE KKSGACEEHS TPQAGEVRLK
MKVEGMTCHS CTSTIEGKVG KLQGVQRIKV SLDNQEATIV FQPHLITAEE IKKQIEAVGF PAFIKKQPKY
LKLGAIDVER LKNTPVKSSE GSQQKSPSYP SD-------- STTMFTIEGM HCKSCVSNIE SALSTLQYVS
SIVVSLENRS AIVKYNASLV TPEMLRKAIE AISPGQYRVS IASEVESTAS SPSSSSLQKM PLN---IVSQ
PLTQEAVINI NGMTCNSCVQ SIEGVISKKP GVKSIHVSLA NSTGTIEFDP LLTSPETLRE AIEDMGFDAA
LP-------- ---------- --DMKEPLVV IAQPSLETPL LPSSNE---- -----PENVM TSVQNKCYIQ VSGMTCASCV
ANIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------NLR REEGIYSVLV ALTA------ ---------- ---------- ---GKAEVRY
NPAVIQPRVI AEFIR-ELGF GAMVMENAGE GN--GILELV VRGMTCASCV HKIESTLTKH KGIFYCSVAL
ATNKAH--IK YDPEIIGPRD IIHTIGSLGF E----ASLVK -KDRSAN-HL DHKREIKQWR GSFLVSLFFC
IPVMGLMVYM MVMDHHLATL HHNQNMSNEE MINMHSAMFL ERQILPGLSI MNLLSLLLCL PVQFCGGWYF
YIQ--AYKAL K-----HKTA NMDVLIVLAT TIAFAYSLVI LLVAMFERAK V--------N PITFFDTPPM LFVFIALGRW LEHIAKGKTS EALAKLISLQ ATEATIVTLN SENLLL---- ---------- ---------S
EEQVDVELVQ RGDIIKVVPG GKFPVDGRVI EGHSMVDESL ITGEAMPVAK KPGSTVIAGS INQNGSLLIR
ATHVGADTTL SQIVKLVEEA QTSKAPIQQF ADKLSGYFVP FIVLVSIVTL LVWIIIGFQN FEIVETYFPG
YNRSISRTET IIRFAFQASI TVLCIACPCS LGLATPTAVM VGTGVGAQNG ILIKGGEPLE MAHKVKVVVF
DKTGTITHGT PVVNQVKVLV ESNKISRNK- ---------- ---------- ILAIVGTAES ----------
NSEHPLGAAV TKYCKKELDT ---------- ---------- ----ETLGTC TDFQVVPGCG ISCKVTNIEG
LLHKSNLKIE ENNIKNASLV QIDAINEQSS TSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNG------
----LVISND VDESMIEHER RGRTAVLVTI DDELCG---- -LIAIADTVK PEAELAVHIL KSMGLEVVLM
TGDNSKTARS IASQVGIT-- KVFAEVLPSH KVAKVKQLQE EG-------K RVAMVGDGIN DSPALAMANV
GIAIGTGTDV AIEAADVVLI RN------DL LDVVASIDLS RKTVKRIRIN FVFALIYNLV GIPIAAGVFL
PIG-LVLQPW MGSAAMAASS VSVVLSSLFL KLYRKP---T YDNYELHPRS HTGQRSPSE- ----ISVHVG
IDDTSRNSPR LGLLDRIVNY SRASINSLL- ----SDKRSL NSVVTSEP-D KHSLLVGDFR EDDDTTL----
---------- ---------- -------MEP NMDANSITIT VEGMTCISCV RTIEQQIGKV NGVHHIKVSL
E--EKSATVI YNPKLQTPKT LQEAIDDMGF DALLHNANPL PVLTNTVFLT VTAPLALPWD HIQSTLLKTK
GVTGVKISPQ QRSAVVTIIP SVVSANQIVE LVPDL----- --SLDMGTQE KKSGTSEEHS TPQAGEVLLK
MRVEGMTCHS CTSTIEGKVG KLQGVQRIKV SLDNQEATIV YQPHLITAEE IKKQIEAVGF PAFIKKQPKY
LKLGAIDVER LKSTPVKSSE GSQQKSPAYP SD-------- SAITFTIDGM HCKSCVSNIE SALSTLQYVS
SIVVSLENRS AIVKYNASLV TPEILRKAIE AVSPGQYRVS ISSEVESPTS SPSSSSLQKM PLN---LVSQ
PLTQEVVINI NGMTCNSCVQ SIEGVISKKP GVKSIHVSLT NSTGTIEYDP LLTSPEPLRE AIEDMGFDAV
LPA------- ---------- --DMKEPLVV IAQPSLETPL LPSTTE---- -----PENVM TPVQNKCYIQ VSGMTCASCV
ANIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------NLR REEGIYSVLV ALMA------ ---------- ---------- ---GKAEVRY
NPAVIQPRVI AELIR-ELGF GAVVMENAGE GN--GILELV VRGMTCASCV HKIESTLTKH KGIFYCSVAL
ATNKAH--IK YDPEIIGPRD IIHTIGNLGF E----ASLVK -KDRSAN-HL DHKREIKQWR GSFLVSLFFC
IPVMGLMIYM MVMDHHLATL NHNQNMSNEE MINMHSSMFL ERQILPGLSI MNLLSLLLCL PVQFCGGWYF
YIQ--AYKAL R-----HKTA NMDVLIVLAT TIAFAYSLVI LLVAMYERAK V--------N PITFFDTPPM LFVFIALGRW LEHIAKGKTS EALAKLISLQ ATEATIVTLN SENLLL---- ---------- ---------S
EEQVDVELVQ RGDIIKVVPG GKFPVDGRVI EGHSMVDESL ITGEAMPVAK KPGSTVIAGS INQNGSLLIR
ATHVGADTTL SQIVKLVEEA QTSKAPIQQF ADKLSGYFVP FIVLVSIVTL LVWIIIGFQN FEIVEAYFPG
YNRSISRTET IIRFAFQASI TVLCIACPCS LGLATPTAVM VGTGVGAQNG ILIKGGEPLE MAHKVKVVVF
DKTGTITHGT PVVNQVKVLV ESNKISRNK- ---------- ---------- ILAIVGTAES ----------
NSEHPLGAAV TKYCKQELDT ---------- ---------- ----ETLGTC TDFQVVPGCG ISCKVTNIEG
LLHKSNLKIE ENNIKNASLV QIDAINEQSS PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNG------
----LVISND VDESMIEHER RGRTAVLVTI DDELCG---- -LIAIADTVK PEAELAVHIL KSMGLEVVLM
TGDNSKTARS IASQVGIT-- KVFAEVLPSH KVAKVKQLQE EG-------K RVAMVGDGIN DSPALAMASV
GIAIGTGTDV AIEAADVVLI RN------DL LDVVASIDLS RKTVKRIRIN FVFALIYNLI GIPIAAGVFL
PIG-LVLQPW MGSAAMAASS VSVVLSSLFL KLYRKP---T YDNYELRPRS HTGQRSPSE- ----ISVHVG
IDDTSRNSPR LGLLDRIVNY SRASINSLL- ----SDKRSL NSVVTSEP-D KHSLLVGDFR EDDDTTL----
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- --------MK KSFAFDNVGY EGGLDGLGPS SQVATSTVRI LGMTCQSCVK SIEDRISNLK
GIISMKVSLE QGSATVKYVP SVVCLQQVCH QIGDM----- --GFEASIAE GKAASWPSRS LP-AQEAVVK
LRVEGMTCQS CVSSIEGKVR KLQGVVRVKV SLSNQEAVIT YQPYLIQPED LRDHVNDMGF EAAIKSKVAP
LSLGPIDIER LQSTNPKRPL SSANQNFNNS ETLGHQGSHV VTLQLRIDGM HCKSCVLNIE ENIGQLLGVQ
SIQVSLENKT AQVKYDPSCI SPVALQRAIE ALPPGNFKVS LPDGAEGSGT DHRSSSSHSP GLPLRENQVQ
GTCSTTLIAI AGMTCASCVH SIEGMISQLE GVQQISVSLA EGTATVLYNP AVISPEELRA AIEDMGFEAS
VVSESCSTNP LGNHSAGNSM VQTTDGTPTS LQEVAPHTGR LPANHA--PD ILAKSPQSTR AVAPQKCFLQ
IKGMTCASCV SNIER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------NLQ KEAGVLSVLV ALMA------ ---------- ----------
---GKAEIKY DPEVIQPLEI AQFIQ-DLGF EAAVMEDYAG SD--GSIELT ITGMTCASCV HNIESKLTRT
NGITYASVAL ATSKAL--VK FDPEIIGPRD IIIIIEEIGF H----ASLAQ -RNPNAH-HL DHKMEIKQWK
KSFLCSLVFG IPVMALMIYM LIPS------ ---------- -NEPHQSMVL DHNIIPGLSI LNLIFFILCT
FVQLLGGWYF YVQ--AYKSL G-----HRSA NMDVLIVLAT SIAYVYSLVI LVVAVAEKAE R--------S
PVTFFDTPPM LFVFIALGRW LEHLAKSKTS EALAKLMSLQ ATEATVVTLG EDNLII---- ----------
---------R EEQVPMELVQ RGDIVKVVPG GKFPVDGKVL EGNTMADESL ITGEAMPVTK KPGSTVIAGS
INAHGSVPIK ATHVGNDTTL AQIVKLVEEA QMSKAPIQQL ADRFSGYFVP FIIIMSTLTL VVWIVIGFID
FGVVQRYFPN PNKHISQTEV IIWFAFQTSI TVLCIACPCS LGLATPTAVM VGTGVAAQNG ILIKGGKPLE
MAHKIKTVMF DKTGTIIHGV PRVMRVLLLG DVATLPLRK- ---------- ---------- VLAVVGTAEA
---------- SSEHPLGVAV TKYCKEELGT ---------- ---------- ----ETLGYC TDFQAVPGCG
IGCKVSNAED ILAHSERPLS ---------A PASHLNEAGS LPA------- -EKDAAPQTF SVLIGNREWL
RRNG------ ----LTISSD VSDAMTDHEM KGQTAILVAI DGVLCG---- -MIAIADAVK QEAALAVHTL
QSMGVDVVLI TGDNRKTARA IATQVGIN-- KVFAGVLPSH KVAKVQELQN KG-------K KVAMVGDGVN
DSPALAQADM GVAIGTGTDV AIEAADVVLI RN------DL LDVVASIHLS KRTVRRIRIN LVLALIYNLV
GIPIAAGVFM PIG-IVLQPW MGSAAMAASS VSVVLSSLQL KCYKKP---D LERYEAQAHG HMKPLTASQN
---FVSEQEQ CQEVWR--KR VISAFLKSPA MPASLLCSV- ----LSWLCR CP-------- ----------
-----------
---------- ---------- ---------- ---------- ---------M PEQERQITAR EG-ASRKILS
------KLSL PTRAWEPAMK KSFAFDNVGY EGGLDGLGPS SQVATSTVRI LGMTCQSCVK SIEDRISNLK
GIISMKVSLE QDSATVKYVP SVVCLQQVCH QIGDM----- --GFEASIAE GKAASWPSRS LP-AQEAVVK
LRVEGMTCQS CVSSIEGKVR KLQGVVRVKV SLSNQEAVIT YQPYLIQPED LRDHVNDMGF EAAIKSKVAP
LSLGPIDIER LQSTNPKRPL SSANQNFNNS ETLGHQGSHV VTLQLRIDGM HCKSCVLNIE ENIGQLLGVQ
SIQVSLENKT AQVKYDPSCT SPVALQRAIE ALPPGNFKVS LPDGAEGSGT DHRSSSSHSP GSPPR-NQVQ
GTCSTTLIAI AGMTCASCVH SIEGMISQLE GVQQISVSLA EGTATVLYNP SVISPEELRA AIEDMGFEAS
VVSESCSTNP LGNHSAGNSM VQTTDGTPTS VQEVAPHTGR LPANHA--PD ILAKSPQSTR AVAPQKCFLQ
IKGMTCASCV SNIER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------NLQ KEAGVLSVLV ALMA------ ---------- ----------
---GKAEIKY DPEVIQPLEI AQFIQ-DLGF EAAVMEDYAG SD--GNIELT ITGMTCASCV HNIESKLTRT
NGITYASVAL ATSKAL--VK FDPEIIGPRD IIKIIEEIGF H----ASLAQ -RNPNAH-HL DHKMEIKQWK
KSFLCSLVFG IPVMALMIYM LIPS------ ---------- -NEPHQSMVL DHNIIPGLSI LNLIFFILCT
FVQLLGGWYF YVQ--AYKSL R-----HRSA NMDVLIVLAT SIAYVYSLVI LVVAVAEKAE R--------S
PVTFFDTPPM LFVFIALGRW LEHLAKSKTS EALAKLMSLQ ATEATVVTLG EDNLII---- ----------
---------R EEQVPMELVQ RGDIVKVVPG GKFPVDGKVL EGNTMADESL ITGEAMPVTK KPGSTVIARS
INAHGSVLIK ATHVGNDTTL AQIVKLVEEA QMSKAPIQQL ADRFSGYFVP FIIIMSTLTL VVWIVIGFID
FGVVQKYFPN PNKHISQTEV IIRFAFQTSI TVLCIACPCS LGLATPTAVM VGTGVAAQNG ILIKGGKPLE
MAHKIKTVMF DKTGTITHGV PRVMRVLLLG DVATLPLRK- ---------- ---------- VLAVVGTAEA
---------- SSEHPLGVAV TKYCKEELGT ---------- ---------- ----ETLGYC TDFQAVPGCG
IGCKVSNVEG ILAHSERPLS ---------A PASHLNEAGS LPA------- -EKDAVPQTF SVLIGNREWL
RRNG------ ----LTISSD VSDAMTDHEM KGQTAILVAI DGVLCG---- -MIAIADAVK QEAALAVHTL
QSMGVDVVLI TGDNRKTARA IATQVGIN-- KVFAEVLPSH KVAKVQELQN KG-------K KVAMVGDGVN
DSPALAQADM GVAIGTGTDV AIEAADVVLI RN------DL LDVVASIHLS KRTVRRIRIN LVLALIYNLV
GIPIAAGVFM PIG-IVLQPW MGSAAMAASS VSVVLSSLQL KCYKKP---D LERYEAQAHG HMKPLTASQ-
----VSVHIG MDDRWRDSPR ATPWDQVSYV SQVSLSSLT- ----SDKPSR HSAAADDDGD KWSLLLNGRD
EEQYI------
---------- ---------- ---------- ---------- ---------- ---------- ----------
---------- --------MK KSFAFDNVGY EGGLDGLGPS SQVATSTVRI LGMTCQSCVK SIEDRISNLK
GIISMKVSLE QGSATVKYVP SVVCLQQVCH QIGDM----- --GFEASIAE GKAASWPSRS LP-AQEAVVK
LRVEGMTCQS CVSSIEGKVR KLQGVVRVKV SLSNQEAVIT YQPYLIQPED LRDHVNDMGF EAAIKSKVAP
LSLGPIDIER LQSTNPKRPL SSANQNFNNS ETLGHQGSHV VTLQLRIDGM HCKSCVLNIE ENIGQLLGVQ
SIQVSLENKT AQVKYDPSCI SPVALQRAIE ALPPGNFKVS LPDGAEGSGT DHRSSSSHSP GLPHRENQVQ
GTCSTTLIAI AGMTCASCVH SIEGMISQLE GVQQISVSLA EGTATVLYNP AVISPEELRA AIEDMGFEAS
VVSESCSTNP LGNHSAGNSM VQTTDGTPTS LQEVAPHTGR LPANHA--PD ILAKSPQSTR AVAPQKCFLQ
IKGMTCASCV SNIER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------NLQ KEAGVLSVLV ALMA------ ---------- ----------
---GKAEIKY DPEVIQPLEI AQFIQ-DLGF EAAVMEDYAG SD--GSIELT ITGMTCASCV HNIESKLTRT
NGITYASVAL ATSKAL--VK FDPEIIGPRD IIIIIEEIGF H----ASLAQ -RNPNAH-HL DHKMEIKQWK
KSFLCSLVFG IPVMALMIYM LIPS------ ---------- -NEPHQSMVL DHNIIPGLSI LNLIFFILCT
FVQLLGGWYF YVQ--AYKSL G-----HRSA NMDVLIVLAT SIAYVYSLVI LVVAVAEKAE R--------S
PVTFFDTPPM LFVFIALGRW LEHLAKSKTS EALAKLMSLQ ATEATVVTLG EDNLII---- ----------
---------R EEQVPMELVQ RGDIVKVVPG GKFPVDGKVL EGNTMADESL ITGEAMPVTK KPGSTVIAGS
INAHGSVPIK ATHVGNDTTL AQIVKLVEEA QMSKAPIQQL ADRFSGYFVP FIIIMSTLTL VVWIVIGFID
FGVVQRYFPN PNKHISQTEV IIWFAFQTSI TVLCIACPCS LGLATPTAVM VGTGVAAQNG ILIKGGKPLE
MAHKIKTVMF DKTGTIIHGV PRVMRVLLLG DVATLPLRK- ---------- ---------- VLAVVGTAEA
---------- SSEHPLGVAV TKYCKEELGT ---------- ---------- ----ETLGYC TDFQAVPGCG
IGCKVSNAED ILAHSERPLS ---------A PASHLNEAGS LPA------- -EKDAAPQTF SVLIGNREWL
RRNG------ ----LTISSD VSDAMTDHEM KGQTAILVAI DGVLCG---- -MIAIADAVK QEAALAVHTL
QSMGVDVVLI TGDNRKTARA IATQVGIN-- KVFAGVLPSH KVAKVQELQN KG-------K KVAMVGDGVN
DSPALAQADM GVAIGTGTDV AIEAADVVLI RN------DL LDVVASIHLS KRTVRRIRIN LVLALIYNLV
GIPIAAGVFM PIG-IVLQPW MGSAAMAASS VSVVLSSLQL KCYKKP---D LERYEAQAHG HMKPLTASQN
---FVSEQEQ CQEVWR--KR VISAFLKSPA MPASLLCSV- ----LSWLCR CP-------- ----------
-----------
---------- ---------- ---------- ---------- ---------M PEQERQITAR EG-ASRKILS
------KLSL PTRAWEPAMK KSFAFDNVGY EGGLDGLGPS SQVATSTVRI LGMTCQSCVK SIEDRISNLK
GIISMKVSLE QGSATVKYVP SVVCLQQVCH QIGDM----- --GFEASIAE GKAASWPSRS LP-AQEAVVK
LRVEGMTCQS CVSSIEGKVR KLQGVVRVKV SLSNQEAVIT YQPYLIQPED LRDHVNDMGF EAAIKSKVAP
LSLGPIDIER LQSTNPKRPL SSANQNFNNS ETLGHQGSHV VTLQLRIDGM HCKSCVLNIE ENIGQLLGVQ
SIQVSLENKT AQVKYDPSCT SPVALQRAIE ALPPGNFKVS LPDGAEGSGT DHRSSSSHSP GSPPR-NQVQ
GTCSTTLIAI AGMTCASCVH SIEGMISQLE GVQQISVSLA EGTATVLYNP AVISPEELRA AIEDMGFEAS
VVSESCSTNP LGNHSAGNSM VQTTDGTPTS LQEVAPHTGR LPANHA--PD ILAKSPQSTR AVAPQKCFLQ
IKGMTCASCV SNIER----- ---------- ---------- ---------- ---------- ----------
---------- ---------- -------NLQ KEAGVLSVLV ALMA------ ---------- ----------
---GKAEIKY DPEVIQPLEI AQFIQ-DLGF EAAVMEDYAG SD--GNIELT ITGMTCASCV HNIESKLTRT
NGITYASVAL ATSKAL--VK FDPEIIGPRD IIKIIEEIGF H----ASLAQ -RNPNAH-HL DHKMEIKQWK
KSFLCSLVFG IPVMALMIYM LIPS------ ---------- -NEPHQSMVL DHNIIPGLSI LNLIFFILCT
FVQLLGGWYF YVQ--AYKSL R-----HRSA NMDVLIVLAT SIAYVYSLVI LVVAVAEKAE R--------S
PVTFFDTPPM LFVFIALGRW LEHLAKSKTS EALAKLMSLQ ATEATVVTLG EDNLII---- ----------
---------R EEQVPMELVQ RGDIVRVVPG GKFPVDGKVL EGNTMADESL ITGEAMPVTK KPGSTVIAGS
INAHGSVLIK ATHVGNDTTL AQIVKLVEEA QMSKAPIQQL ADRFSGYFVP FIIIMSTLTL VVWIVIGFID
FGVVQKYFPN PNKHISQTEV IIRFAFQTSI TVLCIACPCS LGLATPTAVM VGTGVAAQNG ILIKGGKPLE
MAHKIKTVMF DKTGTITHGV PRVMRVLLLG DVATLPLRK- ---------- ---------- VLAVVGTAEA
---------- SSEHPLGVAV TKYCKEELGT ---------- ---------- ----ETLGYC TDFQAVPGCG
IGCKVSNVEG ILAHSERPLS ---------A PASHLNEAGS LPA------- -EKDAAPQTF SVLIGNREWL
RRNG------ ----LTISSD VSDAMTDHEM KGQTAILVAI DGVLCG---- -MIAIADAVK QEAALAVHTL
QSMGVDVVLI TGDNRKTARA IATQVGIN-- KVFAEVLPSH KVAKVQELQN KG-------K KVAMVGDGVN
DSPALAQADM GVAIGTGTDV AIEAADVVLI RN------DL LDVVASIHLS KRTVRRIRIN LVLALIYNLV
GIPIAAGVFM PIG-IVLQPW MGSAAMAASS VSVVLSSLQL KCYKKP---D LERYEAQAHG HMKPLTASQ-
----VSVHIG MDDRWRDSPR ATPWDQVSYV SQVSLSSLT- ----SDKPSR HSAAADDDGD KWSLLLNGRD
EEQYI------
---------- ---------- ---------- ---------- ---------M PEQERKVTAK EA--SRKILS
------KLAL PTRPWGQSMK QSFAFDNVGY EGGLDSTCFI LQLTTGVVSI LGMTCHSCVK SIEDRISSLK
GIVSIKVSLE QGSATVKYVP SVLNLQQICL QIEDM----- --GFEASAAE GKAASWPSRS SP-AQEAVVK
LRVEGMTCQS CVSSIEGKIR KLQGVVRVKV SLSNQEAVIT YQPYLIQPED LRDHICDMGF EAAIKNRTAP
LRLGPIDINK LESTNLKRAA VPPIQNSNHL ETPGHQQNHL ATLPLRIDGM HCKSCVLNIE GNIGQLPGVQ
NIHVSLENKT AQVQYDSSCI TPLFLQTAIE ALPPGYFKVS LPDGLEKESG SSSVPSLGSS ----QRQQEP GPCRTAVLTI
TGIPRDSSVQ PMEDMLSQMK GVQQIDISLA EGTGAVLYDP SVVSSDELRT AVEDMGFEVS VNPENITTNR
VS---SGNSV PQAVGDSPGS VQNMASDTRG LLTHQG--PG YLSDSPPSPG GTASQKCFVQ IKGMTCASCV
SNIER----- ---------- ---------- ---------- ---------- ---------- ----------
---------- -------SLQ RHAGILSVLV ALMS------ ---------- ---------- ---GKAEVKY
DPEVIQSPRI AQLIE-DLGF EAAIMEDNTV SE--GDIELI ITGMTCASCV HNIESKLTRT NGITYASVAL
ATSKAH--VK FDPEIIGPRD IIKVIEEIGF H----ASLAH -RNPNAH-HL DHKTEIKQWK KSFLCSLVFG
IPVMGLMIYM LIP |
