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Publications:
  1. Stein A, Vaseduvan G, Carter NS, Ullman B, Landfear SM, Kavanaugh MP. Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters. J. Biol. Chem. 278(37):35127-34 (2003).
  2. Arastu-Kapur S, Ford E, Ullman B, Carter NS. Functional analysis of an inosine-guanosine transporter from Leishmania donovani. The role of conserved residues, aspartate 389 and arginine 393. J. Biol. Chem. 278(35):33327-33 (2003).
  3. Heby O, Roberts SC, Ullman B. Polyamine biosynthetic enzymes as drug targets in parasitic protozoa. Biochem. Soc. Trans. 31(2):415-9 (2003).
  4. Carter, N.S., Rager, N., and Ullman, B. In: Molecular and Medical Parasitology, J.J. Marr, T. Nilsen, and R. Komuniecki (Eds.), Chapter 9, Academic Press Limited, London (in press).
  5. Jardim, A., Rager, N., Liu, W., Furuya, T., Parsons, M., and Ullman, B. Peroxisomal Targeting Protein 14 (PEX14) from Leishmania donovani. Molecular, Biochemical, and Immunocytochemical Characterization. Mol. Biochem. Parasitol. 124(1-2):51-62 (2002).
  6. Bashor, C., Denu, J.M., Brennan, R.G., and Ullman, B. Kinetic Mechanism of Adenine Phosphoribosyltransferase from Leishmania donovani. Biochemistry 41:4020-4031 (2002)
  7. Roberts, S.C., Scott, J., Gasteier, J., Jiang, Y., Brooks, B., Jardim, A., Carter, N.S., Heby, O., and Ullman, B. S-Adenosylmethionine Decarboxylase from Leishmania donovani. Molecular, Genetic, and Biochemical Characterization of Null Mutants and Overproducers. J. Biol. Chem. 277:5902-5909 (2002).
  8. Schumacher, M.A., Bashor, C.J., Song, M.H., Otsu, K., Zhu, S., Parry, R.J., Ullman, B., and Brennan, R.G. The Structural Mechanism for GTP Stabilized Oligomerization and Catalytic Activation of the Toxoplasma gondii Uracil Phosphoribosyltransferase Proc. Natl. Acad. Sci. USA 99:78-83 (2002).
  9. Rager, N., Ben Mamoun, C., Carter, N.S., Goldberg, D.E., and Ullman, B. Localization of the Plasmodium falciparum PfNT1 Nucleoside Transporter to the Parasite Plasma Membrane. J. Biol. Chem. 276:41095-41099 (2001).
  10. Dubessay, P., Ravel, C., Bastien, P., Lignon, M.F., Ullman, B., Pagès, M., and Blaineau, C. Effect of Large Targeted Deletions on the Mitotic Stability of an Extra Chromosome Mediating Drug-Resistance in Leishmania Nucl. Acids Res. 29:3231-3240 (2001).
  11. Roberts, S.C., Jiang, Y., Jardim, A., Carter, N.S., Heby, O., and Ullman, B. Spermidine Synthase from Leishmania donovani: Gene Cloning and Characterization of Null Mutants Mol. Biochem. Parasitol. 115:217-226 (2001).
  12. Vasudevan, G., Ullman, B., and Landfear, S.M. Point Mutations in a Nucleoside Transporter Gene from Leishmania donovani Confer Drug Resistance and Alter Substrate Specificity Proc. Natl. Acad. Sci. USA. 98:6092-6097 (2001).
  13. Carter, N.S., Landfear, S.M., and Ullman, B. Nucleoside Transporters of Parasitic Protozoa. Parasitol. Today Trends Parasitol. 17:142-144 (2001).
  14. Carter, N.S., Drew, M., Sanchez, M., Vasudevan, G., Landfear, S.M., and Ullman, B. Cloning of a Novel Inosine-Guanosine Transporter Gene from Leishmania donovani by Functional Rescue of a Transport-deficient Mutant. J. Biol. Chem. 275:20935-20941 (2000).
  15. Jardim, A., Liu, W., Zheleznova, E., and Ullman, B. Peroxisomal Targeting Signal-1 Receptor Protein PEX5 from Leishmania donovani. Molecular, Biochemical, and Immunocytochemical Characterization. J. Biol. Chem. 275:13637-13644 (2000).
  16. Carter, N. S., Mamoun, C.B., Liu, W., Silva, E.O., Landfear, S.M., Goldberg, D.E, and Ullman, B. Isolation and Functional Characterization of the PfNT1 Nucleoside Transporter Gene from Plasmodium falciparum. J. Biol. Chem. 275:10683-10691 (2000).
  17. Schumacher, M.A., Scott, D.M., Mathews, I.I., Ealick, S.E., Roos, D.S., Ullman, B, and Brennan, R.G. Crystal Structures of Toxoplasma gondii Adenosine Kinase Reveal a Novel Catalytic Mechanism and Prodrug Binding. J. Mol. Biol. 296:549-567 (2000).
  18. Jardim, A., Bergeson, S.E., Shih, S., Carter, N., Lucas, R.W., Merlin, G., Myler, P.J., Stuart, K., and Ullman, B. Xanthine Phosphoribosyltransferase of Leishmania donovani. Molecular Cloning, Biochemical Characterization, and Genetic Analysis. J. Biol. Chem. 274:34403-34410 (1999).
  19. Chiang, C.-W., Sullivan, W.J., Donald, R.G.K., Roos, D.S., Carter, N., Ullman, B., el Kouni, M., and Wilson, C.M. The Adenosine Transporter of Toxoplasma gondii: Identification by Insertional Mutagenesis, Cloning, and Recombinant Expression. J. Biol. Chem. 274: 35255-25361 (1999).
  20. Sanchez, M.A., Ullman, B., Landfear, S.M., and Carter, N.S. Cloning and Functional Expression of a Gene Encoding a P1 Type Nucleoside Transporter from Trypanosoma brucei. J. Biol. Chem. 274:30244-30249 (1999).
  21. Darling, J.A., Sullivan, W.J., Carter, D., Ullman, B., and Roos, D.S. Recombinant Expression, Purification, and Characterization of Toxoplasma gondii Adenosine Kinase. Mol. Biochem. Parasitol. 103:15-23 (1999).
  22. Phillips, C.L., Brennan, R.G., Ullman, B., and Hill, C.P. Crystal Structures of Adenine Phosphoribosyltransferase from Leishmania donovani. EMBO J. 18:3533-3545 (1999).
  23. Kinch, L.N., Scott, J.R., Ullman, B., and Phillips, M.A. Cloning and kinetic characterization of the Trypanosoma cruzi S- adenosylmethionine decarboxylase. Mol. Biochem. Parasitol. 101:1-11(1999).
  24. Jiang, Y., Roberts, S.C., Jardim, A., Carter, N.S., Shih, S., Ariyanayagam, M., Fairlamb, A., and Ullman, B. Ornithine Decarboxylase Gene Deletion Mutants of Leishmania donovani. J. Biol. Chem. 274:3781-3788 (1999).
  25. Vasudevan, G., Carter, N.S., Drew, M.E., Beverley, S.M., Sanchez, M.A., Seyfang, A., Ullman, B., and Landfear, S.M. Cloning of Leishmania Nucleoside Transporter Genes by Rescue of a Transport-Deficient Mutant. Proc. Natl. Acad. Sci. USA 95:9873-9878 (1998).
  26. Shih, S., Stenberg, P., and Ullman, B. Immunolocalization of Trypanosoma brucei Hypoxanthine-Guanine Phosphoribosyltransferase to the Glycosome. Mol. Biochem. Parasitol. 92:367-371 (1998).
  27. Schumacher, M.S., Carter, D., Scott, D.M., Roos, D.S., Ullman, B., and Brennan, R.G. Crystal Structures of Toxoplasma gondii Uracil Phosphoribosyltransferase Reveal the Atomic Basis of Pyrimidine Discrimination and Prodrug Binding. EMBO J. 17:3219-3232 (1998).
  28. Shih, S., Hwang, H.-Y., Carter, D., Stenberg, P., and Ullman, B. Localization and targeting of the Leishmania donovani hypoxanthine- guanine phosphoribosyltransferase to the glycosome. J. Biol. Chem. 273:1534-1541 (1998).
  29. Hwang, H.-Y. and Ullman, B. Genetic Analysis of Purine Metabolism in Leishmania donovani. J. Biol. Chem. 272:19488-18496 (1997).
  30. Carter, D., Donald, R.G.K., Roos, D., and Ullman, B. Expression, Purification, and Characterization of Uracil Phosphoribosyltransferase from Toxoplasma gondii. Mol. Biochem. Parasitol. 87:137-144 (1997).
  31. Jardim, A. and Ullman, B. The Conserved Serine-Tyrosine Dipeptide in Leishmania donovani Hypoxanthine-Guanine Phosphoribosyltransferase is Essential for Catalytic Activity. J. Biol. Chem. 272:8967-73 (1997).
  32. Ullman, B. and Carter, D. Molecular and Biochemical Studies on the Hypoxanthine-Guanine Phosphoribosyltransferases of the Pathogenic Hemoflagellates. Int. J. Parasitol. 27:203-213 (1997).
  33. Hwang, H.-Y., Gilberts, T., Jardim, A., Shih, S., and Ullman, B. Creation of Homozygous Mutants of Leishmania donovani with Single Targeting Constructs. J. Biol. Chem. 271:30840-30846 (1996)
  34. Schumacher, M.S., Carter, D., Roos, D.S., Ullman, B., and Brennan, R.G. Crystal Structures of the Toxoplasma gondii HGXPRTase Reveal the Catalytic Role of a Long Flexible Loop. Nature Structural Biology 3:881-887 (1996).
  35. Phillips, C.L., Ullman, B., and Brennan, R.G. Crystallization of the Purine Salvage Enzyme Adenine Phosphoribosyltransferase. Proteins: Structure, Function, and Genetics 25:510-513 (1996).
  36. Donald, R.G.K., Carter, D., Ullman, B., and Roos, D.S. Insertional Tagging, Cloning and Expression of the Toxoplasma gondii Hypoxanthine-Xanthine-Guanine Phosphoribosyltransferase Gene: Characterization of a New Genetic Marker for Stable Transformation. J. Biol. Chem. 271:14010-14019 (1996).
  37. Jiang, Y., Allen, T.E., Carter, D., Ray, D.S., and Ullman, B. Crithidia fasciculata: Isolation, Sequencing, and Expression of the Hypoxanthine-Guanine Phosphoribosyltransferase Gene. Exp. Parasitol. 82:73-75 (1996).
  38. Allen, T.E., Hwang, H.-Y., Wilson, K, Hanson, S., Jardim, A., and Ullman, B. Cloning and Expression of the Adenine Phosphoribosyltransferase Gene from Leishmania donovani. Mol. Biochem. Parasitol. 74:99-103 (1995).
  39. Allen, T.E., Hwang, H.-Y., Jardim, A., Olafson, R., and Ullman, B. Cloning and Expression of the Hypoxanthine-Guanine Phosphoribosyltransferase from Leishmania donovani. Mol. Biochem. Parasitol. 73:133-145 (1995).
  40. Marr, J. and Ullman, B. Concepts of Chemotherapy. In: Biochemistry and Molecular Biology of Parasites, J.J. Marr and M. Muller (Eds.), Chapter 16, Academic Press Limited, London pp. 323-336 (1995).
  41. Ullman, B. Multidrug Resistance and P-glycoproteins in Parasitic Protozoa. J. Bioenerg. Biomemb. 27:77-84 (1995).
  42. Jardim, A., Hansen, S., Ullman, B., Caprioli, R.M. and Olafson, R.W. Cloning and Structure-Function Analysis of the Leishmania donovani Kinetoplastid Membrane Protein - 11. Biochem. J. 305:315-320 (1995).
  43. Ullman, B. and Carter, D. Hypoxanthine-Guanine Phosphoribosyltransferase as a Therapeutic Target in Protozoal Infections. Infect. Agents Dis. 4:29-40 (1995).
  44. Tornevik, Y., Ullman, B., Balzarini, J., Wahren, B., and Eriksson, S. Cytotoxicity of 3'-Azido-3'-Deoxythymidine in Cultured CEM T-Lymphoblastoid Cells Correlates with AZTMP Levels, while Anti-HIV Effect Correlates with AZTTP Levels in Mutants with Different Levels of Thymidine Kinase. Biochem. Pharmacol. 49:829-837 (1995).
  45. Ullman, B. and Allen, T.E. Hypoxanthine-Guanine Phosphoribosyltransferase in Trypanosomatids: A Rational Target for Antiparasitic Chemotherapy. In: Molecular Approaches to Parasitology, John Boothroyd (Ed.), Wiley-Liss Division. pp. 123-141 (1995).
  46. Wilson K., Berens. R.L., Sifri, C.D. and Ullman, B. Amplification of the Inosinate Dehydrogenase Gene in Trypanosoma brucei gambiense Due to an Increase in Chromosome Copy Number. J. Biol. Chem. 269:28979-28987 (1994).
  47. Allen, T.E. and Ullman, B. Molecular Characterization and Overexpression of the Hypoxanthine-Guanine Phosphoribosyltransferase Gene from Trypanosoma cruzi. Mol. Biochem. Parasitol. 65:233-245 (1994).
  48. Sifri, C.D., Wilson, K., Smolik, S., Forte, M., and Ullman, B. Cloning and Sequence Analysis of a Drosophila melanogaster cDNA Encoding IMP Dehydrogenase. Biochim. Biophys. Acta Gene Struct. Expression 1217:103-106 (1994).
  49. Allen, T.E. and Ullman, B. Cloning and Expression of the Hypoxanthine-Guanine Phosphoribosyltransferase Gene from Trypanosoma brucei. Nucl. Acids Res. 21:5431-5439 (1993).
  50. Chow, L.M.C., Wong, A.K.C., Ullman, B. and Wirth, D.F. Cloning and Functional Analysis of an Extrachromosomally Amplified Multidrug Resistance-like Gene in Leishmania enriettii. Mol. Biochem. Parasitol. 60:195-208 (1993).
  51. Ullman, B., Henderson, D.M., Sifri, C.D., Hendrickson, N. and Wirth, D.F. Amplification of a Multidrug Resistance Gene in Leishmania donovani. In: Current Trends in Leishmania Research, A.N. Bhaduri, M.K. Basu, A.K. Sen, and S. Kumar (Eds.), Publications & Information Directorate (CSIR), New Delhi, India, pp. 152-160 (1993).
  52. Hendrickson, N., Sifri, C.D., Henderson, D.M., Allen, T.E., Wirth, D.F. and Ullman, B. Molecular Characterization of the ldmdr1 Multidrug Resistance Gene from Leishmania donovani. Mol. Biochem. Parasitol. 60:53-64 (1993).
  53. Hendrickson, N. Allen, T.E. and Ullman B. Molecular Characterization of Phosphoribosylpyrophosphate Synthetase from Leishmania donovani. Mol. Biochem. Parasitol. 59:15-28 (1993).
  54. Hanson, S., Beverley, S.M., Wagner, W. and Ullman, B. Unstable Amplification of Two Extrachromosomal Elements in _-Difluoromethylornithine-Resistant Leishmania donovani. Mol. Cell. Biol. 12:5499-5507 (1992).
  55. Wilson, K., Beverley, S.M. and Ullman, B. Stable Amplification of a Linear Extrachromosomal DNA in Mycophenolic Acid-Resistant Leishmania donovani. Mol. Biochem. Parasitol. 55:197-206 (1992).
  56. Langford, C.K., Ewbank, S.A., Hanson, S.S., Ullman, B. and Landfear, S.M. Molecular Characterization of Two Genes Encoding Members of the Glucose Transporter Superfamily in the Parasitic Protozoan Leishmania donovani. Mol. Biochem. Parasitol. 55:51-64 (1992).
  57. Henderson, D.M., Hanson, S., Allen, T.E., Wilson, K., Greenberg, M.L., Coulter-Karis, D.E., Greenberg, M.L., Hershfield, M.S. and Ullman, B. Cloning of the Gene Encoding Leishmania donovani S-Adenosylhomocysteine Hydrolase, a Potential Target for Antiparasitic Chemotherapy. Mol. Biochem. Parasitol. 53:169-184 (1992).
  58. Owens, J.K., Shewach, D., Ullman, B. and Mitchell, B. Resistance to 1-_-D-Arabinofuranosylcytosine in Human T Lymphoblasts Mediated by Mutations within the Deoxycytidine Kinase Gene. Cancer Res. 52:2389-2393 (1992).
  59. Henderson, D.M., Sifri, C.D., Rodgers, M., Wirth, D.F., Hendrickson, N. and Ullman, B. Multidrug Resistance in Leishmania donovani is Conferred by Amplification of a Gene Homologous to the Mammalian mdr1 Gene. Mol. Cell. Biol. 12:2855-2865 (1992).
  60. Langford, C.K., Ullman, B., and Landfear, S.M. Leishmania: Codon Utilization of Nuclear Genes. Exp. Parasitol. 74:360-361 (1992).
  61. Kierdaszuk, B., Bohman, C., Ullman, B. and Eriksson, S. Substrate Specificity of Human Deoxycytidine Kinase Toward Antiviral 2',3'-Dideoxynucleoside Analogs. Biochem. Pharmacol. 43:197-206 (1992).
  62. Hanson, S., Adelman, J. and Ullman, B. Amplification and Molecular Cloning of the Ornithine Decarboxylase Gene of Leishmania donovani. J. Biol. Chem. 267:2350-2359 (1992).
  63. Wilson, K., Hanson, S., Landfear, S.M. and Ullman, B. Nucleotide Sequence of the Leishmania donovani medRNA Gene. Nucleic Acids Res. 19:5787 (1991).
  64. Beck, J.T. and Ullman, B. Genetic Analysis of Folate Transport and Metabolism in Leishmania donovani. In: Biochemical Protozoology, Taylor & Francis, Ltd., pp. 554-559 (1991).
  65. Beck, J.T. and Ullman, B. Biopterin Conversion to Reduced Folates by Leishmania donovani Promastigotes. Mol. Biochem. Parasitol. 49:21-28 (1991).
  66. Wilson, K., Collart, F., Huberman, E., Stringer, J. and Ullman, B. Amplification and Molecular Cloning of the IMP Dehydrogenase Gene of Leishmania donovani. J. Biol. Chem. 266:1665-1671 (1991).
  67. Beck, J.T. and Ullman, B. Nutritional Requirements of Wild Type and Folate Transport-Deficient Leishmania donovani for Pterins and Folates. Mol. Biochem. Parasitol. 43:221-230 (1990).
  68. Hanson, S., McCartan, K., Sabina, R.L., Holmes, E.W. and Ullman, B. Adenylate Deaminase Deficiency in a Mutant Murine T Cell Lymphoma Cell Line. J. Biol. Chem. 265:11474-11481 (1990).
  69. Crawford, C.R., Catherine Y.C. NG, Ullman, B. and Belt, J.A. Identification and Reconstitution of the Nucleoside Transporter of CEM Human Leukemia Cells. Biochim. Biophys. Acta 1024:289-297 (1990).
  70. Coons, T., Hanson, S., Bitonti, A.J., McCann, P.P. and Ullman, B. Alpha-Difluoromethylornithine Resistance in Leishmania donovani Associated with Increased Ornithine Decarboxylase Activity. Mol. Biochem. Parasitol. 39:77-90 (1990).
  71. Nagy, L.E., Diamond, I., Collier, K., Lopez, L., Ullman, B. and Gordon, A.S. Adenosine Required for Ethanol-Induced Heterologous Desensitization. Molec. Pharmacol. 36:744-748 (1989).
  72. Ullman, B., Carrera-Valenzuela, E. and Coons, T. Leishmania donovani: Isolation and Characterization of Sodium Stibogluconate (Pentostam) Resistant Cell Lines. Exper. Parasitol. 69:157-163 (1989).
  73. Beck, J. and Ullman, B. Affinity Labeling of the Folate-Methotrexate Transporter from Leishmania donovani. Biochemistry 28:6931-6937 (1989).
  74. Beck, J. and Ullman, B. Characterization of a Mutant Clone of Leishmania donovani deficient in Folate Transport. In: Purine and Pyrimidine Metabolism In Man - V, 253B:533-538 (1989).
  75. Beck, J. and Ullman, B. Expression of a Novel High Affinity Purine Base Transport System in Mutant Mouse S49 Cells Does Not Require a Functional Nucleoside Transporter. In: Purine and Pyrimidine Metabolism In Man - V, 253B:525-532 (1989).
  76. Ullman, B. Dideoxycytidine Metabolism in Wild Type and Mutant CEM Cells Deficient in Nucleoside Transport or Deoxycytidine Kinase. In: Purine and Pyrimidine Metabolism In Man - V, 253B:415-420 (1989).
  77. Hanson, S. and Ullman, B. AMP Deaminase and Thymidine Kinase Deficiencies in a Mutant Mouse S49 Clone. In: Purine and Pyrimidine Metabolism In Man - V, 253B:79-86 (1989).
  78. Ullman B. Adenosine, Deoxyadenosine, and Deoxyguanosine. In: Drug Resistance in Mammalian Cells, Radhey S. Gupta (Ed.), Vol. I, CRC Press, pp. 69-88 (1989).
  79. Ullman B. Mycophenolic Acid. In: Drug Resistance in Mammalian Cells, Radhey S. Gupta (Ed.), Vol. I, CRC Press, pp. 59-68 (1989).
  80. Allen, T.E., Henschel, E.V., Coons, T., Cross, L., Conley, J. and Ullman, B. Purification and Characterization of the Adenine Phosphoribosyltransferase and Hypoxanthine-Guanine Phosphoribosyltransferase Activities from Leishmania donovani. Mol. Biochem. Parasitol. 33:273-281 (1989).
  81. Ullman B. Mutational Analysis of Nucleoside and Nucleobase Transport. In: Resistance to Antineoplastic Drugs, D. Kessel (Ed.), Chapter 17, CRC Press, pp. 293-315 (1989).
  82. Ullman, B., Coons, T., McCartan, K. and Rockwell, S. Genetic Analysis of 2',3'-Dideoxycytidine Metabolism in Cultured Human T Lymphoblasts. J. Biol. Chem. 263:12391-12396 (1988).
  83. Spigelman, Z., Duff, R., Beardsley, G.P., Broder, S., Cooney, D., Landau, N.R., Mitsuya, H., Ullman, B. and McCaffrey, R. 2',3'- Dideoxyadenosine is Selectively Toxic for Tdt - Positive Cells. Blood 71:1601-1608 (1988).
  84. Kaur, K., Coons, T., Emmett, K. and Ullman, B. Methotrexate-resistant Leishmania donovani Genetically Deficient in the Folate-Methotrexate Transporter. J. Biol. Chem. 263:7020-7028 (1988).
  85. Ullman, B. Genetic Analysis of Folate Transport in Leishmania donovani. In: Recent Advances in Molecular Genetics of the Parasitic Protozoa, Cold Spring Harbor Press, New York, pp. 52-57 (1988).
  86. Beck, J. and Ullman, B. Genetic Demonstration that the Mutationally Expressed Nucleobase Transporter of Mouse S49 Cells is Nonconcentrative. Exp. Cell Res. 171:254-258 (1987).
  87. Aronow, B. and Ullman, B. In situ Regulation of Mammalian CTP Synthetase by Allosteric Inhibition. J. Biol. Chem. 262:5106-5112 (1987).
  88. Beck, J.T. and Ullman, B. Genetic Demonstration of Bidirectionality in the High Affinity Purine Base Transporter of Mutant Mouse S49 Cells. J. Biol. Chem. 262:2393-2397 (1987).
  89. Ullman, B., Patrick, J. and McCartan, K. Expression of the High-Affinity Purine Nucleobase Transporter in Mutant Mouse S49 Cells Does Not Require a Functional Wild-Type Nucleoside-Nucleobase Transporter. Mol. Cell. Biol. 7:97-103 (1987).
  90. Aronow, B., Kaur, K., McCartan, K. and Ullman, B. Two High Affinity Nucleoside Transporters in Leishmania donovani. Mol. Biochem. Parasitol. 22:29-37 (1987).
  91. Kaur, K., Emmett, K., McCann, P.P., Sjoerdsma, A. and Ullman, B. Effects of DL-alpha-Difluoromethylornithine on Leishmania donovani Promastigotes. J. Protozool. 33:518-521 (1986).
  92. Aronow, B., Toll, D., Patrick, J., McCartan, K. and Ullman, B. Dipyridamole-Insensitive Nucleoside Transport in Mutant Murine T-Lymphoma Cells. J. Biol. Chem. 261:14467-14473 (1986).
  93. Aronow, B., Toll, D., Patrick, J., Hollingsworth, P. and Ullman, B. Expression of a Novel High-Affinity Purine Nucleobase Transport Function in Mutant Mammalian T Lymphoblasts. Mol. Cell. Biol. 6:2957-2962 (1986).
  94. Aronow, B., Hollingsworth, P., Patrick, J. and Ullman, B. Incomplete Nucleoside Transport Deficiency with Increased Hypoxanthine Capability in Mutant T- Lymphoblastoid Cells. Mol. Cell. Biol. 6:1296-1303 (1986).
  95. Kaur, K, Iovannisci, D.M. and Ullman, B. Adenine Phosphoribosyltransferase-deficient Leishmania donovani. In: Purine and Pyrimidine Metabolism In Man - V, 195B:553-557 (1986).
  96. Aronow, B. and Ullman, B. Mammalian Mutants Genetically Altered in CTP Synthetase Activity. In: Purine and Pyrimidine Metabolism In Man - V, 195B:263-269 (1986).
  97. Aronow, B. and Ullman, B. Mutant Mouse Cells with Nitrobenzylthioinosine-Insensitive Nucleoside Transport Function. In: Purine and Pyrimidine Metabolism In Man - V, 195B:79-83 (1986).
  98. Aronow, B. and Ullman, B. Role of the Nucleoside Transport Function in the Transport and Salvage of Purine Nucleobases. J. Biol. Chem. 261:2014-2019 (1986).
  99. Aronow, B. and Ullman, B. Thymidine Incorporation in Nucleoside Transport- Deficient Cells. J. Biol. Chem. 260:16274-16278 (1985).
  100. Weinberg, G.L., Ullman, B., Wright, C.M. and Martin, D.W., Jr. Exogenous Thymidine, Endogenous Deoxynucleotides, and Mutagenesis in Mammalian Cells. Somat. Cell Mol. Gen. 11:413-419 (1985).
  101. Emmett, K., Patrick, J., Aronow, B. and Ullman, B. Regulation of Purine Biosynthesis in G1 Phase-arrested Mammalian Cells. J. Cell Physiol. 125:277-287 (1985).
  102. Ullman, B. Arabinosylguanine Toxicity in Syngeneic Cultured Human T and B Lymphoblasts. Ann. N.Y. Acad. Sci. 451:328-331 (1985).
  103. Aronow, B. and Ullman, B. Genetic Analysis of the 6-Thiobenzylpurine Binding Site of the Nucleoside Transporter in Mouse Lymphoblasts. Proc. Soc. Exp. Biol. Med. 179:463-471 (1985).
  104. Aronow, B., Allen, K., Patrick, J. and Ullman, B. Altered Nucleoside Transporters in Mammalian Cells Selected for Resistance to the Physiological Effects of Inhibitors of Nucleoside Transport. J. Biol. Chem. 260:6226-6233 (1985).
  105. Cohen, A. and Ullman, B. Analysis of the Drug Synergism between Thymidine and AraC using Mouse S49 T Lymphoma Mutants. Cancer Chemother. Pharmacol. 14:70-73 (1985).
  106. Iovannisci, D.M., Goebel, D., Kaur, K., Allen, K. and Ullman, B. Genetic Analysis of Adenine Metabolism in Leishmania donovani: Evidence for Diploidy at the Adenine Phosphoribosyltransferase Locus. J. Biol. Chem. 259:14617-14623 (1984).
  107. Cohen, A. and Ullman, B. Role of Intracellular dTTP Levels in Fluorodeoxyuridine Toxicity. Biochem. Pharmacol. 33:3298-3301 (1984).
  108. Ullman, B. Pyrazolopyrimidine Metabolism in Parasitic Protozoa. Pharmaceutical Res. 1:194-203 (1984).
  109. Ullman, B. and Martin, D.W. Jr. Selective Cytotoxicity of Arabinosylguanine Toward Cultured T Lymphoblasts. J. Clin. Invest. 74:951-955 (1984).
  110. Iovannisci, D.M. and Ullman, B. Mutational Analysis of Adenosine Kinase Function in Leishmania donovani Promastigotes. Mol. Biochem. Parasitol. 12:139-151 (1984).
  111. Aronow, B., Watts, T., Lassetter, J., Washtien, W. and Ullman, B. Biochemical phenotype of 5-fluorouracil-resistant murine T-lymphoblasts with genetically altered CTP synthetase activity. J. Biol. Chem. 259:9035-9043 (1984).
  112. Robinson, N., Kaur, K., Emmett, K., Iovannisci, D.M. and Ullman, B. Biochemical Genetic Analysis of Formycin B Action in Leishmania donovani. J. Biol. Chem. 259:7637-7643 (1984).
  113. Iovannisci, D.M., Kaur, K., Young, L. and Ullman, B. Genetic Analysis of Nucleoside Transport in Leishmania donovani. Mol. Cell Biol. 4:1013-1019 (1984).
  114. Eriksson, S., Groppi, V., Ullman, B. and Martin, D.W., Jr. Cell-Cycle Dependent Variations in the Levels of Deoxyribonucleoside Triphosphate in Mouse T-lymphoma Cells. In: Purine Metabolism in Man - IV. Adv. Exp. Med. Biol. 165B:407-410 (1984).
  115. Ullman, B., IMP Dehydrogenase Mutants: Cell Culture Model for Hyperuricemia. In: Purine Metabolism in Man - IV. Adv. Exp. Med. Biol. 165A:373-379 (1984).
  116. Iovannisci, D.M. and Ullman, B. Single Cell Cloning of Leishmania Parasites in Purine-defined Medium: Isolation of Drug-resistant Variants. In: Purine Metabolism In Man - IV. Adv. Exp. Med. Biol. 165A:239-243 (1984).
  117. Ullman, B. and Kaur, K. Biochemical Effects of Dipyridamole on Purine Overproduction and Excretion in Mutant Murine T-Lymphoblasts. J. Biol. Chem. 258:9620-9622 (1983).
  118. Iovannisci, D. and Ullman, B. High Efficiency Plating Method for Leishmania Promastigotes in Semi-defined or Completely Defined Medium. J. Parasitol. 69:633-636 (1983).
  119. Ullman, B., Kaur, K. and Watts, T. Genetic Studies on the Role of the Nucleoside Transport Function in Nucleoside Efflux, the Inosine Cycle, and Purine Biosynthesis. Mol. Cell Biol. 3:1187-1196 (1983).
  120. Waddell, D. and Ullman, B. Characterization of a Cultured Human T-Cell Line with Genetically Altered Ribonucleotide Reductase Activity: Model for Immunodeficiency. J. Biol. Chem. 258:4226-4231 (1983).
  121. Ullman, B. Characterization of Mutant Murine Lymphoma Cells With Altered Inosinate Dehydrogenase Activities. J. Biol. Chem. 258:523-528 (1983).
  122. Ullman, B., Wormsted, M.A., Cohen, M.B. and Martin, D.W., Jr. Purine Oversecretion in Cultured Murine Lymphoma Cells Deficient in Adenylosuccinate Synthetase: A Genetic Model for Inherited Hyperuricemia and Gout. Proc. Natl. Acad. Sci. USA 79:5127-5131 (1982).
  123. Hershfield, M.S., Fetter, J.E., Small, W.C., Bagnara, A.S., Williams, S.R., Ullman, B., Martin, D.W., Jr., Carson, D.A. and Wasson, D.B. Effects of Mutation Loss of Adenosine Kinase and Deoxycytidine Kinase on DeoxyATP Accumulation and Deoxyadenosine Toxicity in Cultured CEM Human T-lymphoblastoid Cells. J. Biol. Chem. 257:6380-6388 (1982).
  124. Buchwald, M., Ullman, B. and Martin, D.W., Jr. Biochemical and Genetic Analysis of AMP Deaminase Deficiency in Cultured Mammalian Cells. J. Biol. Chem. 256:10346-10353 (1981).
  125. Eriksson, S., Gudas, L.J., Clift, S.M., Caras, I.W., Ullman, B. and Martin, D.W. Jr. Evidence for Genetically Independent Allosteric Regulation Domains of the Protein M1 Subunit of Mouse Ribonucleotide Reductase. J. Biol. Chem. 256:10193-10197 (1981).
  126. Ullman, B., Gudas, L.J., Caras, I.W., Eriksson, S., Wormsted, M.A. and Martin, D.W., Jr. Demonstration of Normal and Mutant Protein M1 Subunits of DeoxyGTP Resistant Ribonucleotide Reductase from Mutant Mouse Lymphoma Cells. J. Biol. Chem. 256:10189-10192 (1981).
  127. Eriksson, S., Gudas, L.J., Ullman, B., Clift, S.M. and Martin, D.W., Jr. DeoxyATP Resistant Ribonucleotide Reductase of Mutant Mouse Lymphoma Cells; Evidence for Heterozygosity for the Protein M1 Subunits. J. Biol. Chem. 256:10184-10188 (1981).
  128. Weinberg, G., Ullman, B., and Martin, D.W., Jr. Mutator Phenotypes in Mammalian Cell Mutants with Abnormal Deoxyribonucleoside Triphosphate Pools. Proc. Natl. Acad. Sci. USA 78:2447-2451 (1981).
  129. Gudas, L.J., Eriksson, S., Ullman, B. and Martin, D.W., Jr. Purification of a Mutant Ribonucleotide Reductase from Cultured Mouse T-lymphoma Cells. Adv. in Enzyme Regula. 19:192-197 (1981).
  130. Ullman, B., Levinson, B.B., Hershfield, M.S. and Martin, D.W., Jr. A Biochemical Genetic Study of the Role of Specific Nucleoside Kinases in Deoxyadenosine Phosphorylation by Cultured Human Cells. J. Biol. Chem. 256:848-852 (1981).
  131. Carson, D.A., Wasson, D.B., Kaye, J., Ullman, D., Martin, D.W., Jr., Robins,R. K. and Montgomery, J. A. Deoxycytidine Kinase-mediated Toxicity of Deoxyadenosine Analogs Toward Malignant human Lymphoblasts in vitro and Toward Murine L1210 Leukemia in vivo. Proc. Natl. Acad. Sci. USA 77:6865-6869 (1980).
  132. Maybaum, J., Ullman, B., Mandel, H.G., Day, J.L. and Sadee, W. Regulation of RNA- and DNA-directed Actions of 5-fluoropyrimidines in Mouse T-lymphoma (S49) Cells. Cancer Res. 40:4209-4215 (1980).
  133. Ullman, B., Clift, S.M., Gudas, L.J., Levinson, B.B., Wormsted, M.A. and Martin, D.W., Jr. Alterations in Deoxyribonucleotide Metabolism in Cultured Cells with Ribonucleotide Reductase Activities Refractory to Feedback Inhibition by 2'-deoxyadenosine Triphosphate. J. Biol. Chem. 255:8308-8314 (1980).
  134. Ullman, B., Wormsted, M.A., Levinson, B.B., Gudas, L.J., Cohen, A., Clift, S. M. and Martin, D.W., Jr. Abnormal Regulation of Purine Metabolism in a Cultured Mouse T-cell Lymphoma Mutant Partially Deficient in Adenylosuccinate Synthetase. In: Purine Metabolism in Man - III, Vol. 122A, Plenum Press, New York, pp. 375-386 (1980).
  135. Meyer, R.B., Jr., Stone, T.E. and Ullman, B. 2'-O-Acyl-6-thioinosine cyclic 3',5'-phosphates as prodrugs of thioinosinic acid. J. Med. Chem. 22:811-815 (1979).
  136. Levinson, B.B., Ullman, B., and Martin, D.W., Jr. Pyrimidine Pathway Variants of Cultured Mouse Lymphoma Cells with Altered Levels of both Orotate Phosphoribo- syltransferase and Orotidylate Decarboxylase. J. Biol. Chem. 254:4396-4401 (1979).
  137. Cohen, A., Gudas, L.J., Ullman, B., and Martin, D.W., Jr. Nucleotide Metabolism in Cultured T-cells and in Cells of Patients Deficient in ADA and PNP. Proceedings of the Ciba Foundation Symposium (London, November 1978), 99-113 (1979).
  138. Cohen, A., Ullman, B., and Martin, D.W., Jr. Characterization of a Mutant Mouse Lymphoma Cell with Deficient Transport of Purine and Pyrimidine Nucleosides. J. Biol. Chem. 254:112-116 (1979).
  139. Ullman, B., Levinson, B.B., Ullman, D.H. and Martin, D.W., Jr. Isolation and Characterization of Cultured Mouse T-lymphoma Cells Deficient in Uridine-Cytidine Kinase. J. Biol. Chem. 254:8736-8739 (1979).
  140. Ullman, B., Clift, S.M., Cohen, A., Gudas, L.J., Levinson, B.B., Wormsted, M.A. and Martin, D.W., Jr. Abnormal Regulation of de novo Purine Synthesis and Purine Salvage in a Cultured Mouse T-lymphoma Mutant Partially Deficient in Adenylosuccinate Synthetase. J. Cell Physiol. 99:139-152 (1979).
  141. Ullman, B., Gudas, L.J. and Martin, D.W., Jr. Deoxyadenosine and Deoxyguanosine Cytotoxicity in Cultured Mouse T-lymphoma Cells: A Model for Immunodeficiency Disease. In: Inborn Errors of Specific Immunity, B. Pollara, R.J. Pickering, H.J. Meuwissen and I.H. Porter (Eds.), Academic Press, New York, pp. 237-259 (1979).
  142. Ullman, B., Gudas, L.J., Clift, S.M. and Martin, D.W., Jr. Isolation and Characterization of Purine Nucleoside Phosphorylase Deficient T-lymphoma Cells and Secondary Mutants with Altered Ribonucleotide Reductase: Genetic Model for Immunodeficiency Disease. Proc. Natl. Acad. Sci. USA 76:1074-1078 (1979).
  143. Ullman, B. and Kirsch, J. Metabolism of 5-fluorouracil in Cultured Cells: Protection from Fluorouracil Cytotoxicity by Purines. Mol. Pharmacol. 15:357-366 (1979).
  144. Gudas, L.J., Ullman, B., Cohen, A. and Martin, D.W., Jr. Deoxyguanosine Toxicity in Mouse T-lymphoma: Relationship to Purine Nucleoside Phosphorylase Associated with Immune Dysfunction. Cell 14:531-538 (1978).
  145. Ullman, B., Gudas, L.J., Cohen, A. and Martin, D.W., Jr. Deoxyadenosine Metabolism and Cytotoxicity in Cultured Mouse T-lymphoma Cells: A Model for Immunodeficiency Disease. Cell 14:365-375 (1978).
  146. Gudas, L.J., Cohen, A., Ullman, B., and Martin, D.W., Jr. Analysis of Adenosine Mediated Pyrimidine Starvation using Cultured Wild-type and Mutant Mouse T-lymphoma Cells. Somat. Cell. Genet. 4:201-219 (1978).
  147. Ullman, B., Lee, M., Martin, D.W., Jr. and Santi, D.V. Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for Reduced Folate Cofactors and Antagonism by Methotrexate. Proc. Natl. Acad. Sci. USA 75:980-983 (1978).
  148. Ullman, B., Cohen, A. and Martin, D.W., Jr. Characterization of a Cell Culture Model for the Study of Adenosine Deaminase- and Purine Nucleoside Phosphorylase-deficient Immunologic Disease. Cell 9:205-211 (1976).
  149. Ullman, B. and Perlman, R.L. Purification and Characterization of a Phosphoprotein Phosphatase from Bovine Adrenal Cortex. Biochim. Biophys. Acta 403:303-411 (1975).
  150. Ullman, B., and Perlman, R.L. Chemically Phosphorylated Protamine: A New Substrate for the Study of Phosphoprotein Phosphatase Activity. Biochem. Biophys. Res. Commun. 63:424-431 (1975).
by Wendy Showell