Jacob Raber
Associate Professor, Behavioral Neuroscience, OHSU
Affiliate Associate Scientist, Division of Neuroscience, ONPRC, OHSU
e-mail: raberj@ohsu.edu
Major Areas:
- Apolipoprotein E
- Androgen Receptor
- Learning and memory
- Irradiation and neurogenesis
- mGluR8 and the regulation of anxiety
- Long-term effects of methamphetamine exposure on cognition
- Histamine and brain function
Previous Positions
1991-1995 Postdoctoral Researcher, The Scripps Research Institute, La Jolla, CA.
1996-1998 Staff Research Investigator, Gladstone Molecular Neurobiology Program, San Francisco, CA; Adjunct Instructor of Neurology, University of California, San Francisco, California.
1998-2000 Staff Research Scientist I, Gladstone Institute of Neurological Disease, San Francisco, CA.
2000-2001 Staff Research Scientist II, Gladstone Institute of Neurological Disease, San Francisco, CA.
1998-2001 Assistant Adjunct Professor of Neurology, University of California, San Francisco, CA.
Education
B.Sc. (1983) Free University, Amsterdam, The Netherlands
M.Sc. (1986) Free University, Amsterdam, The Netherlands
Ph.D. (1991) The Weizmann Institute of Science, Rehovot, Israel
Research Interests
Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.
We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.
Selected Recent Publications
van Meer, P., Pfankuch, T., Raber, J. (2007) Reduced histamine levels and H 3 receptor antagonist-induced histamine release in the amygdala of Apoe -/- mice. J Neurochem ( in press, published on line June 15, 2007 )
Berteau-Pavy F, Park B, Raber J (2007) Effects of sex and APOE e4 on object recognition and spatial navigation in the elderly. Neuroscience 147, 6-17.
Acevedo SF, de Esch IJP, Raber J (2007) Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. Neuropsychopharmacology, 32, 665-672.
Villasana L, Acevedo SF, Poage C, Raber J (2006) Sex- and ApoE Isoform-dependent effects of radiation on cognitive function. Radiation Research 166, 883-891.
Benice T, Rizk A, Kohama S, Pfankuch T, Raber J (2006) Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain Microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137, 413-423.
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Last Updated: November 13, 2007