Research Projects

Grant-Funded Laboratory Research

NIH Training Grant:

• Integrated and Translational Training in Anesthesiology Research - Patricia D. Hurn, Ph.D., Principal Investigator
  

NIH Program Project Grants:

• Sex, Sex Steroids, and Neuroprotection -
  Patricia D. Hurn, Ph.D., Program Director
  
  
  • Project 1:  Role of STAT/CART Pathway in Estrogen-Mediated Neuroprotection
    • Nabil J. Alkayed, M.D., Ph.D. –PI
       
  • Project 2:  Testosterone and Cerebral Ischemia
    • Patricia D. Hurn, Ph.D. -PI
    • Nabil Alkayed, M.D., Ph.D. -CoI
    • Oline Rønnekleiv, Ph.D. -CoI
       
  • Project 3:  Neuroprotective Effects of Estrogen and Testosterone in Experimental Autoimmune Encephalomyelitis (EAE)
    • Halina Offner, Dr. Med. -PI
    • Marjorie Grafe, M.D.,Ph.D -CoI
       
  • Core A:  Administration
    • Patricia D. Hurn, Ph.D. -PI
       
  • Core B:  Tissue Analysis
    • Oline Rønnekleiv, Ph.D. -PI
       
  • Core C:  Animal Models
    • Stephanie J. Murphy, V.M.D., Ph.D. -PI

• Mechanisms of Regulation of Cerebral Blood Flow & Metabolism –
  Patricia D. Hurn, Ph.D. - Program Director
   
  • Core B:  Cells and Tissues – Culture and Neuropathology
    • Marjorie Grafe, M.D., Ph.D -PI
       
  • Core C:  Transgenic Animals
    • Stephanie J. Murphy, V.M.D., Ph.D. -PI

• Role of P450 Epoxygenase in Control of the Cerebral Circulation and Protection from Ischemic Brain Injury (NIH, R01 Grant)
  • Nabil J. Alkayed, M.D., Ph.D. –PI

• Osmotherapy in Acute Ischemic Stroke (NIH, R01 Grant)
  • Anish Bhardwaj, M.D. –PI
     
• Anesthesia-Induced Developmental Neuroapoptosis in NHP
  • Ansgar Brambrink, M.D., Ph.D. –PI
     
• Neuroprotective Properties of Androgens and the Role of Salt Induced Kinase 1 (SIK1) in Androgen-Mediated Neuroprotection (American Heart Association Fellowship)
  • Jian Cheng, Ph.D. –PI
     
• Allopregnanolone through Modulation of GABA_A Receptors (NIH, Predoctoral Individual National Research Service Award)
  
  • Melissa Hernandez, B.S. –PI
    


• GABA-A Receptor Rescue as a Neuroprotective Strategy in Cerebral Ischemia 
  (NIH, RO1 Grant)
  • Paco Herson, Ph.D. -PI
    
    
• Cerebral Ischemia in the Female (NIH, R01 Grant)
  • Patricia D. Hurn, Ph.D. –PI
     
• Estrogen and Testosterone in Experimental Stroke (NIH, R01 Grant)
  • Patricia D. Hurn, Ph.D. –PI

• Sex Specific Ischemic Cell Signaling (American Heart Association Bugher Grant)
  • Patricia D. Hurn, Ph.D. –PI

• Role of Estradiol in Outcome of Renal Whole-Body Ischemia-Reperfusion Injury
  (Medical Research Foundation of Oregon Grant)
  • Michael P. Hutchens, MD, MA - PI
    
    
• P450 Eicosanoids: Novel Nerve-Derived Relaxing Factors in the Brain
  • Jeffrey J. Iliff, B.S. - PI
    
   
• Role of Soluble Epoxide Hydrolase Polymorphisms in Stroke Injury and Brain Inflammation (OHSU Medical Research Foundation Grant)
  • Ines P. Koerner, M.D., Ph.D. –PI
     
• Sex Differences in Astrocyte Cell Death (American Heart Association Grant)
  • Mingyue Liu, M.D., Ph.D. –PI

• Perioperative Stroke Risk and Cerebral Preconditioning in the Female (NIH, R01 Grant)
  • Stephanie J. Murphy, V.M.D., Ph.D. –PI

• Opioid-Mediated Myocardial Adaptation to Stress (Dept. of Veterans Affairs)
  • Donna M. Van Winkle, Ph.D. –PI
    

Grant-Funded Clinical Research

• Building Interdisciplinary Research Careers in Women's Health
  
  • Beth Darnall, Ph.D –PI
   
• Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women
  
  • Beth Darnall, Ph.D –CI
    

• Web-Based Cognitive Behavioral Therapy for Adolescents with Chronic Pain: Measuring Functional Outcomes
  (American Pain Society's Future Leaders Pain Small Research Grants Program)
  
  • Anna C. Long, Ph.D. –PI  
   
• Sleep-Wake Disturbances in Adolescents with Chronic Pain (NIH, R01 Grant)
  
  • Tonya M. Palermo, Ph.D. –PI  

• Web-Based Cognitive Behavioral Treatment for Chronic Pain in Children (NIH, R21 Grant)
• Tonya M. Palermo, Ph.D. –PI
   

Industry-Sponsored Clinical Research

• IV Acetaminophen (Cadence Pharmaceuticals)
  • Julio Gonzalez-Sotomayer, MD -PI
   
• Non-Opioid Pain Control Following Total Knee Arthroscopy (TKA)
  • Jean-Louis Horn, MD -PI
   
• ABT-894 Clinical Trial (Abbott Laboratories)
  • Brett Stacey, MD. -PI
    
    
• Sugammadex Comparative Study (Organon USA, Inc., a part of Schering-Plough)
  • Mark Zornow, MD -PI