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Various studies within the Layton Center have an MRI component. Our involvement with these studies is tailored to the unique needs of each project. Listed below are the studies with an MRI component and brief statement about each one.
• Longitudinal Studies
OBAS
(Imaging Protocol)

 

 The purpose of the Oregon Brain Aging Study (OBAS) is to obtain information on the effects of aging on the brain. This is an ongoing, longitudinal study. Those being invited to participate in the study are individuals who are age 55 or older,healthy, and are living in the community. Subjects are recruited through presentations at retirement facilities and senior fairs, flyers and word of mouth in the community. Those expressing interest are screened over the phone and then a medical release is completed to request current medical records. Those meeting the health criteria are scheduled for the initial visits which are considered screening visits. Informed consent is obtained at this time. Determination of eligibility is based on data collected at these visits including normal cognition, normal blood chemistry results and normal MRI of the brain.

AADAPt
(Imaging Protocol)
 
The African American Dementia & Aging Project is a 5 year to lifetime study that focuses on age related memory loss in African Americans. MRI images are obtained at the first (baseline) visit, with subsequent scans each year thereafter. One primary interest is the relationship between levels of cortisol and its impact on the hippocampus and other structures of the brain involved in memory.
 
The Dementia Prevention Study is a 42-month research trial investigating standardized ginkgo biloba extract (GBE). MRI images are obtained at the first (baseline) visit, with subsequent scans each year thereafter. Each MRI scan receives a full brain analysis, using REGION. The volumetric data obtained will be statistically analyzed for comparative rates of brain atrophy.
 
• Clinical Trials
Cat’s Claw Trial
(Imaging Protocol)
 
The purpose of this research study is to evaluate the effectiveness and safety of PTI-00703™ versus placebo (an inactive substance) for treating Alzheimer’s disease. PTI-00703™ is derived from the plant Uncaria Tomentosa (Cat’s Claw) and is considered a naturally occurring food supplement. The study lasts approximately 52 weeks and will involve approximately 50 persons at two sites.
 
The DANA study is an 18-month study designed to track Alzheimer’s disease in the living patient. Disease progression is tracked using cerebrospinal fluid (CSF) measures and MRI image analysis (comparative MRI’s are acquired at both the baseline and the one year visits).
CSF Cortisol/ApoE
(Imaging Protocol)
 
The CSF Cortisol/ApoE study is a 2-4 week study designed to measure the effect of ApoE genotypes on CSF cortisol concentrations in persons with AD, non-demented older persons, and normal young and middle-aged persons.
Galantamine Study
(Imaging Protocol)
 
The Galantamine Study is an international, multi-center study that is 24 months in duration. MRI scans are obtained at the screening, 12 month, 24 month and occasionally the 3 month visits.
Clinic patients volunteering for research
(Imaging Protocol)
 
Many of the patients from our Alzheimer's and Memory Disorders Clinic volunteer for annual testing, brain donation, and MRI brain scans. Combining these three forms of data provides insight into the biological mechanisms of the disease.
 
•

Guam Study
(Imaging Protocol)
   
In collaboration with the University of Guam and the University of Califormia San Diego, Dr. Kaye is the principal investigator of the imaging component of the NIH-funded study “Age related neurodegenerative diseases in Micronesia (Project 3).” This project will establish whether specific MRI brain regions can distinguish among the various forms of dementia likely to affect Chamorro people, such as Mariana Dementia and parkinsonism-dementia complex (PDC).
 
•
Alzheimer's Disease Cooperative Study -- MCI Study
(Imaging Protocol)
   
Coordinated by principal investigators Drs. Ronald Petersen (Mayo Clinic) and Michael Grundman (UCSD), the imaging component of this study looks at brain volumes which may help identify which patients with mild cognitive impairment may progress to frank dementia.