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Layton Center Protocol (Scanner Methods)
1. T1 Sagittals 
  • 5mm thick, 0.0 space
2. Dual Echo Coronals 
  •  Proton Density (TE=32)
•  T2-weighted (TE=80)
•  4mm thick, 0.0 space
 3. Coronal 3D SPGR
  • Extended dynamic range
• skin-to-skin
• TR=minimum
• TE=minimum full
• FOV 24 x 18, matrix 256 x 192
• 2mm thick, 0.0 space
• NEX 2
• flip angle=25
 
ADCS/Mayo Protocol (Scanner Methods)
 1. Sagittal 2D spin echo
  TE = minimum,
TR = up to 700 msec,
FOV = 24 cm,
5mm slices with no gap(interleaved),
256 x 192 matrix,
one repetition,
frequency encoding direction S/I.
Cover side to side – i.e., skin-to-skin
 2. Coronal 3D volumetric spoiled gradient echo
  flip angle 25°or45°
TE = minimum FULL,
TR = minimum,
FOV = 22 cm x 16.5 cm,
124 slices at 1.6 mm/slice,
matrix 256 x 192,
3/4 phase FOV (rectangular FOV),
± 10 kHz BW (if you have the Echo Speed platform, - +16 kHz BW otherwise),
time 7-8 min.
 3. Axial spin density, fast spin echo
  20 cm FOV,
3 mm interleaved (no gap),
TR = 2000 msec,
TE =minimum,
echo train length =4,
±16 kHz BW,
matrix 256 x192,
I sat.,
time 3:20
 4. Axial T2 fast spin echo
  20 cm FOV,
3 mm interleaved (no gap),
TR=3000 msec,
TE =102 msec,
echo train length = 8,
±16 kHz BW,
256 x 192matrix,
I sat,
time 2:40
 
Galantamine Study (Scanner Methods)
 1. T1-SAGITTALS
  SLICE THICKESS/SPACING: 5.0/1.5
FOV: 26 x 26
MATRIX: 256 x 192
 2. 3D T1 CORONALS
  SLICE THICKESS/SPACING: 1.8/0.0
FOV: 25 x 18
MATRIX: 256 x 192
 3. AXIAL T2 WEIGHTED FLAIR
  SLICE THICKNESS/SPC: 5.0/0.0
FOV: 25 x 25
MATRIX: 256 x 256