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Center
Information |
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| Neuroimaging
Lab
Information |
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Hardware/Software |
Software:
The
Layton Center Imaging Lab primarily uses REGION, a Macintosh-based
application designed by Dr. William Coshow and Jeff Kaye for
the Center.
NIH
Image is also used in the Center to visualize brain images
and for some volumetric procedures, such as hippocampal analysis
and the measurement of the central sulcus for full coronal
analysis. |
Hardware:
The
volumetric analyses are performed on Macintosh computers.
Currently we are using dual processor G4's with flat panel
monitors. |
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Scanner/Scan
Protocol |
For the fourteen years the Center
has been studying MRI scans, all
of the OHSU scans have been acquired
on GE 1.5Tesla magnets. Currently,
OHSU uses an LX and an Horizon scanner.
OHSU has recently added two 3Tesla
Philips scanners; testing is underway
to establish the standard protocols
on these machines. A 3T Siemens scanner
is also available through the OHSU
AIRC.
The Layton Center has a standard
protocol for use in most of our studies. Consistent
use of the same protocol across studies allows us
to pool data for greatly expanded analyses. Other
studies with an imaging component are required to
use protocols designed specifically for these multi-site
studies.
For details of the GE scanner protocol
for each study, hover the mouse pointer
over the study of interest. For further
information about each study, click
on that study's name in the list. |
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Volumetric
Analysis |
| The Layton Center Imaging Laboratory
performs volumetric analysis for many
of the Center’s studies. Some
studies obtain MRIs only to rule out
exclusionary conditions (such as stroke),
while others look to the MRI quantification
as a primary outcome measure. The volumetric
procedure used for each study is tailored
to the investigator’s final data
requirements. The list below, though
not exhaustive, links to more information
about many of the procedures we use
to measure brain volumes of interest. |
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Coronal
analysis – lobar volumes
Hippocampal
volume
Ventricular
Volume
Intracranial
volume
Entorhinal
cortex
Corpus Callosum
Interuncal
Distance (for details, see our publication
Howieson J, Kaye JA, Holm L, Howieson
D. Interuncal distance: marker of
aging and Alzheimer disease. American
Journal of Neuroradiology 14:647-650,
1993.)
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| White / Grey Matter quantification
-- REGION is currently under development
to add the capability to quantify grey
and white matter volumes using a semi-automated
algorithm. |
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