Charles S. Springer, Jr./Professor, Director

Charles Springer

Printable version of CV

EDUCATION/TRAINING:

St. Louis University; St. Louis, Missouri; B.S.Chemistry, 1962
The Ohio State University; Columbus, Ohio; M.S.Chemistry, 1964
The Ohio State University; Columbus, Ohio; Ph.D.Chemistry, 1967
Aerospace Research Laboratory; Wright-Patterson AFB, Ohio; Post-Doctoral Chemistry, 1968

PROFESSIONAL EXPERIENCE:

1965-1968     Research Chemist, Aerospace Research Laboratory; Wright-Patterson Air Force Base, OH
1968              OSU Visiting Research Assistant (Postdoctoral), ARL; Wright-Patterson AFB, OH
1968-1974     Assistant Professor of Chemistry, State University of New York at Stony Brook; Stony Brook, NY
1974-1985     Associate Professor of Chemistry, State University of New York at Stony Brook; Stony Brook, NY
1976-1977     Visiting Associate, Div. of Chemistry & Chem. Eng., The California Inst. of Technol.; Pasadena, CA
1983-1984     Visiting Associate Professor of Medicine, Harvard Medical School NMR Laboratory; Boston, MA
1985              Visiting Associate Professor of Radiology, New England Deaconess Hospital; Boston, MA
1985-2003     Professor of Chemistry, State University of New York at Stony Brook; Stony Brook, NY
1989-1990     Adjunct Professor of Radiology, College of Physicians and Surgeons of Columbia University; NY
1991-1993     Professor of Radiology, State University of New York at Stony Brook; Stony Brook, NY
1993              Guest Scientist, Chemistry Department, Brookhaven National Laboratory; Upton, NY
1994-1996     Chemist, Chemistry Department, Brookhaven National Laboratory; Upton, NY
1996-2003     Senior Chemist, Chemistry Department, Brookhaven National Laboratory; Upton, NY
2003-current   Professor; Director, Adv. Imaging Res. Center, Oregon Health & Science Univ.; Portland, OR

AWARDS AND HONORS

U.S. Air Force Research and Development Award for 1967
Elected to Board of Trustees of the International Society for Magnetic Resonance in Medicine (Aug. 1994 - April, 1997)
Named to Editorial Board of NMR in Biomedicine (June, 1997 - current)
Named Fellow of the International Society for Magnetic Resonance in Medicine (April, 1998)
External Advisory Board, Center for Magnetic Resonance Research, Univ. Minnesota (May, 2000 - current)
Elected Chair, Gordon Research Conference on In Vivo Magnetic Resonance for 2004 (August, 2000 - current) Brookhaven National Laboratory Science and Technology Award for 2001

THE SPRINGER RESEARCH GROUP

For over 35 years, the Springer Research Group has pursued investigations into fundamental magnetic resonance principles. This represents work reported in twenty Ph.D. dissertations, nine M.S. and twenty B.S. theses, as well as that of almost thirty other students, postdoctoral associates and visiting faculty colleagues, and numerous independent collaborators. Important contributions from these efforts include: the introduction of in vivo frequency shift reagents for the resonances of biological cations; the theoretical principles for bulk magnetic susceptibility effects in NMR [this forms the bases for theoretical simulations of the functional MRI (fMRI) phenomenon]; the introduction of the concept of relaxographic imaging [this forms the basis of physical image segmentation]; and the elucidation of the effects of tissue intercompartmental equilibrium water exchange on measured NMR phenomena. To quantify the latter, the powerful fundamental concept of "the NMR shutter-speed" was recently introduced. This finds important applications in MR studies of cancer, multiple sclerosis, stroke; indeed in almost every type of quantitative MR analysis.

SELECTED RECENT PUBLICATIONS: (Selected papers since 1990 are listed below)

W.D. Rooney and C.S. Springer, The Molecular Environment of Intracellular Sodium: 23Na NMR Relaxation, NMR Biomed, 4,      227-245 (1991).

M.S. Albert, W. Huang, J-H. Lee, J.A. Balschi, and C.S. Springer, Aqueous Shift Reagents for High-Resolution Cation NMR. VI.      Titration Curves for In Vivo23Na and 1H2O MRS Obtained from Rat Blood, NMR Biomed., 6, 7-20 (1993).

M.S. Albert, W. Huang, J-H. Lee, C.S. Patlak, and C.S. Springer, Susceptibility Changes Following Bolus Injections, Magn. Res.      Med., 29, 700-708 (1993).

J-H. Lee, C. Labadie, C.S. Springer, and G.S. Harbison, Two-dimensional Inverse Laplace Transform NMR: Altered Relaxation      Times Allow Detection of Exchange Correlation, J. Am. Chem. Soc., 115, 7761-7764 (1993).

K. Clarke, L.C. Stewart, S. Neubauer, J.A. Balschi, T.W. Smith, J.S. Ingwall, J-F. Nedelec, S.M. Humphrey, A.G. Kleber, and      C.S. Springer, Extracellular Volume and Transsarcolemmal Proton Movement During Ischemia and Reperfusion: A 31P NMR      Spectroscopic Study of the Isovolumic Rat Heart, NMR Biomed., 6, 278-286 (1993).

C.S. Springer, Bulk Magnetic Susceptibility Frequency Shifts in Cell Suspensions, NMR Biomed., 7, 198-202 (1994).

C.S. Springer, Physico-Chemical Principles Influencing Magnetopharmaceuticals, in NMR in Physiology and Biomedicine, Ed. by      R.J. Gillies; Academic Press, Inc.; Orlando, FL; pp. 75-99 (1994).

M.S. Albert, G.D. Cates, B. Driehuys, W. Happer, B. Saam, C.S. Springer, and A. Wishnia, Biological Magnetic Resonance Imaging Using Laser-Polarized 129Xe, Nature, 370, 199-201 (1994).

C. Labadie, J-H. Lee, G. Vetek, and C.S. Springer, Relaxographic Imaging, J. Magn. Reson. B., 105, 99-112 (1994).

I. Pályka, W. Huang, and C.S. Springer, The Effects of Bulk Magnetic Susceptibility in NMR, Bull. Magn. Reson. 17, 46-53      (1995).

C.S. Springer, Biological Systems: Spin 3/2 Nuclei, Encyclopedia of Nuclear Magnetic Resonance, Ed. by D.M. Grant and R.K.      Harris; John Wiley and Sons, New York; 2, 940-951 (1996).

W. Huang, I. Palyka, H-F. Li, E.M. Eisenstein, N.D. Volkow, and C.S. Springer, Magnetic Resonance Imaging (MRI) Detection of the Murine Brain Response to Light: Temporal Differentiation and Negative Functional MRI Changes, Proc. Nat. Acad. Sci.      USA 93, 6037-6042 (1996).

M.E. Wagshul, T.M. Button, H-F. Li, Z. Liang, C.S. Springer, K. Zhong, and A. Wishnia, In Vivo MR Imaging and Spectroscopy Using Hyperpolarized 129Xe, Magn. Reson. Med. 36, 183-191 (1996).

J. Ren, C.S. Springer, and A.D. Sherry, Ion-Pairing Interactions Between Co(en)33+ and the 23Na NMR Frequency Shift Reagent      TmDOTP5-, Inorg. Chem. 36, 3493-3498 (1997).

J-H. Lee, X. Li, M.K. Sammi, and C.S. Springer, Using Flow Relaxography to Elucidate Flow Relaxivity, J. Magn. Res. 136, 102-     113 (1999).

C.S. Springer, C.S. Patlak, I. Palyka, and W. Huang,, Principles of Bulk Magnetic Susceptibility and the Sign of the fMRI Response,      Functional Magnetic Resonance Imaging, Ed. by C.T.W. Moonen and P.A. Bandettini; Springer-Verlag, New York , pp. 91-     102 (1999).

M.K. Sammi, C.A. Felder, J.S. Fowler, J-H. Lee, A.V. Levy, X. Li, J. Logan, I. Palyka, W.D. Rooney, N.D. Volkow, G-J.      Wang,, and C.S. Springer, The Intimate Combination of Low- and High-Resolution Image Data: I. Real-Space PET and 1H2O MRI, PETAMRI, Magn. Reson. Med. 42, 345-360 (1999).

C.S. Landis, X. Li, F.W. Telang, P.E. Molina, I. Palyka, G. Vetek, and C.S. Springer, Equilibrium Transcytolemmal Water Exchange Kinetics in Skeletal Muscle in Vivo, Magn. Reson. Med. 42, 467-478 (1999).

M.K. Sammi, J.W. Pan, F.W. Telang, D. Schuhlein, P.E. Molina, N.D. Volkow, C.S. Springer, and H.P. Hetherington, Measurements of Human Brain Ethanol T2 by Spectroscopic Imaging at 4 T, Magn. Reson. Med. 44, 35-40 (2000).

W.D. Rooney, J-H. Lee, X. Li, G-J. Wang, D. Franceschi, C.S. Springer, and N.D. Volkow, 4.0 T Water Proton T1 Relaxation Times in Normal Human Brain and During Acute Ethanol Intoxication, Alcoholism: Clin. Expt. Res. 24, 830-836 (2000).

C.S. Landis, X. Li, F.W. Telang, J.A. Coderre, P.L. Micca, W.D. Rooney, L.L. Latour, G. Vetek, I. Palyka, and C.S. Springer, Determination of MRI Contrast Agent Concentration Time Course in Vivo Following Bolus Injection: Effect of Equilibrium Transcytolemmal Water Exchange, Magn. Reson. Med. 44, 563-574 (2000).

N.D. Volkow, G-J. Wang, J.S. Fowler, W.D. Rooney, C.A. Felder, J-H. Lee, D.J. Schlyer, J.W. Pan, S.J. Gatley, and C.S. Springer, Resting Brain Metabolic Activity in a 4 Tesla Magnetic Field, Magn. Reson. Med. 44, 701-705 (2000).

K. Zhong, X. Li, Y. Shachar-Hill, F. Picart, A. Wishnia, and C.S. Springer, Magnetic Susceptibility Shift Selected Imaging (MESSI) and Localized 1H2O Spectroscopy in Living Plant Tissues, NMR Biomed. 13, 392-397 (2000).

M.F. Ochs, R.S. Stoyanova, T.R. Brown, W.D. Rooney, and C.S. Springer, A Bayesian Markov Chain Monte Carlo Solution of the Bilinear Problem, Bayesian Inference and Maximum Entropy Methods in Science and Engineering, Eds., J.T. Rychert, G.J. Erickson, and C.R. Smith [Melville, NY] Proc. Am. Inst. Phys. 567, 274-284 (2001).

C.S. Springer and W.D. Rooney, Indirectly, Tissue is the Issue: In MRI, Contrast Reagents use the Body's Water Molecules to Enhance Signals, Mod. Drug. Discov. 4, (#10) 53-57 (2001).

C.S. Springer, W.D. Rooney, and X. Li, The Effects of Equilibrium Transcytolemmal Water Exchange on the Determination of Contrast Reagent Concentration In Vivo, Magn. Reson. Med. 47, 422-424 (2002).

M.D. Silva, K.G. Helmer, J-H. Lee, S.S. Han, C.S. Springer, and C.H. Sotak, Deconvolution of Compartmental Water Diffusion Coefficients in Yeast-Cell Suspensions Using Combined T1 and Diffusion Measurements, J. Magn. Reson. 156, 52-63 (2002).

J-H. Lee, and C.S. Springer, Effects of Equilibrium Exchange on Diffusion-Weighted NMR Signals: The Diffusigraphic "Shutter-Speed," Magn. Reson. Med. 49, 450-458 (2003).

J-H. Lee, F.W.Telang, C.S. Springer, and N.D. Volkow, Abnormal Brain Activation to Visual Stimulation in Cocaine Abusers, Life Sciences73, 1953-1961 (2003).

J.D. Quirk, G.L. Bretthorst, T.Q. Duong, A.Z. Snyder, C.S. Springer, J.J.H. Ackerman, and J.J. Neil, Equilibrium Water Exchange Between the Intracellular and Extracellular Spaces of Mammalian Brain, Magn. Reson. Med. 50, 493-499 (2003).

T.E. Yankeelov, W.D. Rooney, X. Li, and C.S. Springer, Variation of the Relaxographic “Shutter-Speed” for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape, Magn. Reson. Med. 50, 1151-1169 (2003).

R. Zhou, S. Pickup, T.E. Yankeelov, C.S. Springer, J.D. Glickson, Simultaneous Measurement of Arterial Input Function and Tumor Pharmacokinetics in Mice by Dynamic Contrast Enhanced Imaging: Effects of Transcytolemmal Water Exchange, Magn. Reson. Med.. 52, 248-257 (2004).

X. Li, W. Huang, T.E. Yankeelov, A. Tudorica, W.D. Rooney, and C.S. Springer, Shutter-Speed Analysis of Contrast Reagent Bolus-Tracking Data: Preliminary Observations in Benign and Malignant Breast Disease, Magn. Reson. Med.. 53, 724-729 (2005).

S. Michaeli, H. Gröhn, D.J. Sorce, R. Kauppinen, C.S. Springer, K. Ugurbil, and M. Garwood, Exchange-Influenced T2? Contrast in Human Brain Images Measured with Adiabatic RF Pulses,Magn. Reson. Med.. 53, 823-829 (2005).

D.C. Medina, X. Li, and C.S. Springer, Pharmaco-thermodynamics of Deuterium-Induced Oedema in Living Rat Brain via 1H2O MRI: Implications for Boron Neutron Capture Therapy of Malignant Brain Tumors, Phys. Med. Biol.. 50, 2127-2139 (2005).

T.E. Yankeelov, W.D. Rooney, W. Huang, J.P. Dyke, X. Li, A. Tudorica, J-H. Lee, J.A. Koutcher, and C.S. Springer, Evidence for Shutter-Speed Variation in CR Bolus-Tracking Studies of Human Pathology, NMR Biomed.. 18, 173-185 (2005).

T.R. Brown, M.F. Ochs, W.D. Rooney, R.S. Stoyanova, X. Li, and C.S. Springer, Bayesian Image Decomposition Applied to Relaxographic Imaging, Int. J. Imag. Sys. Tech.. 15, 2-9 (2005).

X. Li, W.D. Rooney, and C.S. Springer, A Unified MRI Pharmacokinetic Theory: Intravascular and Extracellular Contrast Reagents, Magn. Reson. Med. . 54, 0000-0000 (2005).

by airc@ohsu.edu