Hillary's paper describing the role of Wnt modulator Kremen1 in the lateral line has been published in journal Development. This paper shows a surprising role for Kremen1 in positively modulating canonical Wnt activity in the lateral line primordium.
Katie Drerup received a prestigious Pathway to Independence Award from NINDS. This award will support two years of her postdoctoral research ($90,000/year) and three years of her independent research ($250,000/year). The award is aimed at studying dynein-mediated transport in zebrafish.
This review describes types of multicellular rosettes that form during organ development and maintenance as well as molecular bases of their formation. Read more here>
Here are some picks from the lab hike to Falls Creek Falls. Beatiful place!
Ski trip on Mt Hood,
Matt defended his thesis entitled "Origin of cranial sensory systems". Specifically, Matt studied how cranial sensory placodes (epithelial structures that give rise to the cranial sensory neurons) develop in zebrafish. Matt is moving on to his postdoc at Massachusetts General Hospital in Boston to study chemical genetics of behavior in David Kokel's lab. Congrats and Good Luck!
Molly successfully defended her thesis on the 4th of September. The title of her thesis project is "Regulation of cell shape during development of the nervous system". Over the course of her thesis research, Molly has studied how cells change their shapes during two distinct processes, formation of polarized epithelial rosettes and axon extension. Molly is staying in the lab until mid February, 2014 to finish her axon extension project. Molly is also writing a review article on polarized epithelial rosettes.
Here is the pic of the happy academic child and happy academic dad:
We are excited to report that Katie's paper entitled " JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes" has been published in journal PLoS genetics. This study establishes zebrafish as a model system for in vivo analysis of axonal transport and identifies Jip3 as a crucial adaptor for retrograde transport of pJNK and lysosomes (PUBMED).
Matt McCarroll, a graduate student in the lab, received a one-year Ronny Lacroute fellowship from the Oregon Brain Institute. The fellowship will support Matt's research in identifying cues responsible for induction of cranial placodes in zebrafish. Congratulations Matt!
Hike to Mt St. Helens
The braver part of the lab hiked the rim of Mt St Helens. Check it out:
On the way up:
At the rim:
View from the top (Spirit lake and Mt Adams):
Molly's study shows that FgfR-Ras-MAPK pathway regulates apical constriction in the newly forming rosettes of the posterior lateral line primordium. This pathway is responsible for the apical positioning of Rho-associated kinase which, in turn, is necessary to activate apical constriction. (Pubmed)
Katie Drerup received $30,000 from the Collins Midecal Trust to study axonal transport in zebrafish. Congrats Katie!
Matt's paper shows that graded levels of two transcription factors , Pax2a and Pax8, regulate differentiation of otic and epibranchial placodes in zebrafish. Matt's study also revealed that the canonical Wnt signaling pathway is responsible for maintaining high Pax levels in placodal precursors.(Pubmed).
Hillary McGraw Won a prize for best oral presentation at the Northwest Developmental Biology Conference at Friday Harbor, WA. She won $1,000 to cover her trip to the national meeting of the Society for Developmental Biology in Montreal. The title of her talk was "Canonical Wnt signaling regulates multiple aspects of collective cell migration in the zebrafish posterior lateral line primordium".
Manuscript by Maya Culbertson et al., has been published in journal PlOS ONE. This study revealed that two neural crest populations, chondrogenic and gliogenic crest, play distinct roles during epibranchial ganglia development.
Manuscript by Hillary McGraw et al., has been published in journal Development. This study revealed one of the mechnisms by which progenitor cell identity is regulated during lateral line development and role of Lef1 in this process.
Hillary received a two-year fellowship from Americah Heart Association. This fellowship will fund her research that focuses on specification of progenitor cells during organ development.
Katie and Molly receive $2000 awards from Tartar Trust to attend conference/course of their choice. Congratulations Katie and Molly!
Katie received individual NRSA from NINDS to study axonal transport in zebrafish. Congrats Katie!
Molly received first prize for best oral presentation at NWDB meeting. One thousand $$$ award will cover her travel to the national SDB meeting in Chicago. Have fun Molly!
OHSU community ar Friday Harbor meeting
Katie Drerup received $500 prize as a runner up for best talk presented by a postdoc at the SDB meeting in Albuquerque , NM. She presented her reserach at the plenary postdoc symposium. She also received $400 award from Genentech.
Molly is the recipient of the 2010 graduate fellowship from the NSF. This prestigious award guarantees funding and tuition for 3 years. It will fund Molly's research in lateral line patterning in zebrafish. For more detail about NSF graduate fellowships click here.
Matt McCarroll has joined our lab. Matt will continue Zack's project studying development of cranial placodes and ganglia. Welcome Matt!
Sorry to see you leave Zack, thanks for all your help with setting up the lab and establishing a number of novel techniques!
Molly Harding, a neuroscience student , has recently joined our lab. Molly is interested in lateral line development and plans to study mutants that have patterning defects during lateral line development.
North-West DB meeting at Friday Harbor Labs was fun, see it for yourself:
Catherine (Katie) Drerup will join our lab as a post-doctoral scientist in March of 2009. Katie is currently finishing her thesis research at Northwestern University Interdepartmental Neuroscience Program in the laboratory of Dr. Jill Morris.
Hillary McGraw will start her post-doctoral research in our lab at the end of next spring. Currently, Hillary is a graduate student in the Program of Molecular and Cellular Biology at University of Washington in the laboratory of Dr. David Raible. She is scheduled to defend her thesis in the spring of 2009 and she will start her post-doctoral research in our lab shortly thereafter.
Maya Culbertson has recently joined our lab. Maya has extensive experience in neuroscience research as well as some experience in zebrafish research. She obtained her B.A. in Molecular Biology from Princeton University and her Masters in Forensic Science from National University. Her recent job was at UCSD. Welcome to the lab!
Zachary Lewis graduated from Reed College in 2006 and did his post-graduate fellowship there as well. His thesis research involved studying primordial germ cell differentiation in Threespine Sticklebacks. He won a prestigious Class of '21 award for his thesis research. Big welcome!
Thuy Huynh recently joined the lab as a fish facility manager. Thuy brings extensive experience in managing research zebrafish facility. In addition to the degree in Aquatic and Fisheries Sciences (2003) from the University of Washington, he also spent three years helping to maintain University of Washington zebrafish facility shared by four zebrafish labs.