Degrees:
- BMedSci- University of Newcastle upon Tyne, 1984
- MB, BS- University of Newcastle upon Tyne, 1990
- PhD- University of Newcastle upon Tyne, 1988
Residency:
- Internal Medicine- Royal Brompton National Heart and Lung Hospital, the Hammersmith Hospital, the National Hospitals for Neurology and Neurosurgery and Guy’s Hospital, London, U.K. 1990-1993.
Fellowships:
- Intensive Care Medicine- Guy’s Hospital, London, and Royal Prince Alfred Hospital and Royal North Shore Hospital, Sydney, Australia
- Research- National Institute for Medical Research, Mill Hill, U.K, and Department of Molecular and Cellular Physiology, Stanford University, California.
Research Interests:
- Central regulation of cardiovascular system
- Presynaptic regulation of interneuronal signaling
Representative Publications:
- Smith, S.M., Bergsman, J.B., Harata, N., Scheller, R.H., Tsien, R.W. (2004). Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium. Neuron, 41: 243-256.
- Bailey, T. W., Jin, YH., Doyle, M.W., Smith, S.M., Andresen, M.C. (2006). Vasopressin inhibits glutamate release via two distinct modes in the brainstem. Journal of Neuroscience, 26: 6131-42.
- Komisarof, J.A., Gilkey, G.M., Peters, D.M., Koudelka, C.W., Meyer, M.M., Smith, S.M. (2007) N-Acetylcysteine for Patients with Prolonged Hypotension as Prophylaxis for Acute Renal Failure (NEPHRON). Critical Care Medicine, 35(2):435-441.
- Smith, S. M., Oveson, K.E., Strauss, W., Raven, K., Lefevre, M.C., Ahmann, A.J., Hagg, D.S. (2007) Ultradian variation of blood glucose in ICU patients receiving insulin infusions. Diabetes Care, 30:2503-2505.
- Chen, W, Harnett, M.T., Smith, S.M. (2007) Modulation of neuronal voltage-activated calcium and sodium channels by polyamine and pH. Channels, 1:281-290.
- Phillips, C.R., Chesnutt, M.S., Smith, S.M. (2008) Extravascular Lung Water in Sepsis-Associated ARDS: indexing with predicted body weight improves correlation with severity of illness and survival. Critical Care Medicine, 36: 69-73.
- Smith, S.M., Renden, R., von Gersdorff, H. (2008) Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval. Trends in Neurosciences, 31(11): 559-68.
- Phillips, C.G, Harnett, M.T., Chen, W., Smith, S.M. (2008) Extracellular Calcium-sensing receptor modulates excitatory synaptic transmission. Journal of Neuroscience, 28(46): 12062-12070.
- Vyleta, N., Smith, S.M. (2008) Fast Inhibition of Glutamate-activated Currents by Caffeine. PLoSONE, 3(9):e3155.
- Harnett, M.T., Chen, W., Smith, S.M. (2009) Calcium-sensing receptor: a novel target for aminoglycoside-induced weakness. In press at Neuropharmacology.
Biosketch:
Stephen Smith is an Associate Professor in the Division of Pulmonary & Critical Care Medicine. He was born in Nottingham, UK. He attended college at the University of Newcastle upon Tyne and received a medical degree and Ph.D. Following residency training in internal medicine, which included working at the Brompton, Hammersmith, National and Guy's Hospitals in London, he completed fellowship training in intensive care medicine at Guy`s Hospital in London and at the Royal Prince Alfred and Royal North Shore Hospitals in Sydney, Australia. In 1996, Smith began working as a postdoctoral research fellow in the Department of Molecular and Cellular Physiology at Stanford University. He joined the faculty at OHSU in 2000. He attends in the cardiac-surgical and medical intensive care units. His laboratory employs electrophysiological and imaging techniques to investigate neuronal signaling. This work addresses questions such as how does the brain regulate autonomic function and do presynaptic homeostatic pathways contribute to neuronal toxicity during acute brain dysfunction. He is also a member of the Department of Physiology & Pharmacology.
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