James Lundblad, MD, PhD

• Degrees:
  MD: Columbia University, New York, 1990
  PhD: Columbia University, New York, 1993
• Residency:
  Internal Medicine: Oregon Health & Science University, Portland,1992
• Fellowship:
  Endocrinology-Oregon Health & Science University, Portland, 1993

• Biosketch:
  Regulation of gene expression at the level of transcription requires the coordinated recruitment and assembly at the control regions of genes of a macromolecular complex with a variety of enzymatic and structural functions. The Lundblad laboratory has focused on understanding transcriptional regulation of gene expression by viral oncoproteins, most recently the Adenovirus oncoprotein E1A and two of its targets, the Carboxyl-terminal Binding Protein (CtBP) co-repressor, and the CREB-Binding Protein (CBP)/p300 co-activators. We are currently investigating the roles of cytoplasmic E1A in regulating cytoplasmic processes and signal transduction pathways and are examining the role of CtBP in transcription of genes critical for the regulation of progression through the cell cycle, and how radiation damage, chemotherapeutic agents, and metabolic alterations, including oxidative stressors, regulate CtBP function. Finally, by using fluorescent and crystallographic approaches, we are studying the molecular mechanisms of transcriptional repression by CtBP.
• Recent Publications:
  

  Kashanchi, F., Duvall, J.F., Kwok, R.P.S., Lundblad, J.R., Goodman, R.H., and Brady, J.N. (1998) The coactivator CBP is required for activation of HTLV-1 Tax transactivation in vitro. J. Biol. Chem. 273:34646-52.

  Allen, R.G., Peng, B., Pellegrino, M.J., Miller, E.D., Lundblad, J.R. and Pintar, J.E. (2001) Improper processing of prepro (pp) Orphanin FQ (OFQ)/nociceptin and preproopioimelanocortin (POMC)-derived peptides in mice expressing a defective PC2. J. Neurosci.21:5864-70

  Newman, B.L., Lundblad, J.L., Chen, Y., and Smolik, S.M. (2002) SIR2 affects heterochromatic silencing but not life span in Drosophila. Genetics 162:1675-85

  Madison, D.L., Yaciuk, P., Kwok, R.P.S., and Lundblad, J.R (2002) Acetylation of the adenovirus transforming protein E1A determines nuclear localization by disrupting association with importin-a. J. Biol. Chem. 277:38755-63

  Lu, Q., Hutchins, A.E., Doyle, C.M., Lundblad, J.R., and Kwok, R.P.S. (2003) Acetylation of CREB by CBP enhances CREB-dependent transactivation. J. Biol. Chem. 278:15727-15734.

• All Publications